Published in BMC Med Genet on April 06, 2010
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows. BMC Genomics (2011) 1.52
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes (2012) 1.40
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet (2013) 1.11
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genet (2011) 1.06
Genome-wide analysis of epistasis in body mass index using multiple human populations. Eur J Hum Genet (2012) 1.00
Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Med Genet (2011) 1.00
HDL cholesterol and bone mineral density: is there a genetic link? Bone (2012) 0.99
Lactase persistence and lipid pathway selection in the Maasai. PLoS One (2012) 0.95
MASTOR: mixed-model association mapping of quantitative traits in samples with related individuals. Am J Hum Genet (2013) 0.94
ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis. J Lipid Res (2010) 0.92
Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia. J Lipid Res (2012) 0.89
Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates. PLoS One (2011) 0.89
The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population. PLoS One (2013) 0.86
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. PLoS One (2016) 0.85
Nutrient and food intakes of middle-aged adults at low risk of cardiovascular disease: the international study of macro-/micronutrients and blood pressure (INTERMAP). Eur J Nutr (2011) 0.85
Applications of miRNA technology for atherosclerosis. Curr Atheroscler Rep (2014) 0.84
Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease. Mol Hum Reprod (2013) 0.84
Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture. Sci Rep (2017) 0.81
Analysis of multiple association studies provides evidence of an expression QTL hub in gene-gene interaction network affecting HDL cholesterol levels. PLoS One (2014) 0.79
Measurement of the phospholipase activity of endothelial lipase in mouse plasma. J Lipid Res (2012) 0.79
Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip. Front Genet (2014) 0.79
Association of endothelial lipase genetic polymorphism with lacunar infarction in a Chinese population. Int J Clin Exp Med (2014) 0.77
Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels. Front Genet (2012) 0.76
Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. PLoS One (2014) 0.76
Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits. Methods Mol Biol (2015) 0.76
Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population. Meta Gene (2014) 0.76
A 2-step strategy for detecting pleiotropic effects on multiple longitudinal traits. Front Genet (2014) 0.76
Gene set analyses of genome-wide association studies on 49 quantitative traits measured in a single genetic epidemiology dataset. Genomics Inform (2013) 0.75
Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems. BMC Genomics (2016) 0.75
A genome-wide association study of multiple longitudinal traits with related subjects. Stat (Int Stat Inst) (2016) 0.75
Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. Hum Genet (2016) 0.75
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem (1972) 95.79
Genomic control for association studies. Biometrics (1999) 64.39
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Estimation of significance thresholds for genomewide association scans. Genet Epidemiol (2008) 8.88
Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
On multiple-testing correction in genome-wide association studies. Genet Epidemiol (2008) 3.19
Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies. BMC Bioinformatics (2008) 2.92
Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model. Physiol Genomics (2006) 1.62
Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism. Nat Genet (2009) 1.55
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol (2009) 1.43
The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med (Berl) (2008) 1.35
Gender differences in genetic risk profiles for cardiovascular disease. PLoS One (2008) 1.31
Common and rare ABCA1 variants affecting plasma HDL cholesterol. Arterioscler Thromb Vasc Biol (2000) 1.27
Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet (2009) 1.25
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem (2007) 1.23
Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J (2009) 0.88
The effect of long-term feeding of 10% dietary lactose on serum, liver and aortic cholesterol of the rat and the gerbil. J Nutr (1980) 0.81
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Gait speed and survival in older adults. JAMA (2011) 15.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci (2004) 12.46
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst (2006) 6.02
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood (2004) 5.86
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) (2003) 5.73
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med (2010) 5.20
Frailty: an emerging research and clinical paradigm--issues and controversies. J Gerontol A Biol Sci Med Sci (2007) 4.98
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Hearing loss and incident dementia. Arch Neurol (2011) 4.65
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. JAMA (2004) 4.27
Hearing loss and cognitive decline in older adults. JAMA Intern Med (2013) 4.25
Hearing loss prevalence in the United States. Arch Intern Med (2011) 4.22
The origins of age-related proinflammatory state. Blood (2004) 4.15
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci (2004) 3.96
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab (2005) 3.70
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Hearing loss prevalence and risk factors among older adults in the United States. J Gerontol A Biol Sci Med Sci (2011) 3.63
Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev (2013) 3.63
Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care (2008) 3.54
Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc (2004) 3.48
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc (2003) 3.30
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci (2009) 3.14
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA (2012) 3.10