Published in Methods Mol Biol on January 01, 2015
A survey about methods dedicated to epistasis detection. Front Genet (2015) 0.77
Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders. PLoS Genet (2017) 0.75
Exploring and Harnessing Haplotype Diversity to Improve Yield Stability in Crops. Front Plant Sci (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
The human genome browser at UCSC. Genome Res (2002) 168.23
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
An Extension of the Concept of Partitioning Hereditary Variance for Analysis of Covariances among Relatives When Epistasis Is Present. Genetics (1954) 21.13
Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health (1951) 20.27
Personal genomes: The case of the missing heritability. Nature (2008) 19.56
The NCBI dbGaP database of genotypes and phenotypes. Nat Genet (2007) 17.93
Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res (2008) 15.69
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet (2009) 12.07
The mystery of missing heritability: Genetic interactions create phantom heritability. Proc Natl Acad Sci U S A (2012) 11.23
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet (2002) 9.18
Epistasis: too often neglected in complex trait studies? Nat Rev Genet (2004) 8.66
Epistasis and its contribution to genetic variance components. Genetics (1995) 4.99
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait. Proc Natl Acad Sci U S A (2004) 3.51
Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res (2001) 3.04
Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies. BMC Bioinformatics (2008) 2.92
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet (2011) 2.33
dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks. Bioinformatics (2010) 2.23
A global search reveals epistatic interaction between QTL for early growth in the chicken. Genome Res (2003) 2.13
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
HINT: High-quality protein interactomes and their applications in understanding human disease. BMC Syst Biol (2012) 1.73
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. Arterioscler Thromb Vasc Biol (2008) 1.63
Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. BMC Med Genet (2010) 1.41
Learning from our GWAS mistakes: from experimental design to scientific method. Biostatistics (2012) 1.35
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
A novel statistic for genome-wide interaction analysis. PLoS Genet (2010) 1.19
On the classification of epistatic interactions. Genetics (2009) 1.12
A novel method to identify high order gene-gene interactions in genome-wide association studies: gene-based MDR. BMC Bioinformatics (2012) 1.06
Gene-based interaction analysis by incorporating external linkage disequilibrium information. Eur J Hum Genet (2010) 1.02
Multivariate detection of gene-gene interactions. Genet Epidemiol (2012) 0.98
Identification of epistatic effects using a protein-protein interaction database. Hum Mol Genet (2010) 0.98
Genome-wide analysis of single-locus and epistasis single-nucleotide polymorphism effects on anti-cyclic citrullinated peptide as a measure of rheumatoid arthritis. BMC Proc (2007) 0.95
Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Med Genomics (2012) 0.90
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Natural selection on protein-coding genes in the human genome. Nature (2005) 10.84
Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet (2008) 8.92
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32
Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A (2011) 7.36
Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A (2002) 6.95
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol Biol Evol (2002) 6.44
Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43
Evolutionary changes in cis and trans gene regulation. Nature (2004) 6.24
Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Recent explosive human population growth has resulted in an excess of rare genetic variants. Science (2012) 5.58
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39
Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS One (2008) 4.03
Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics (2004) 3.65
Linkage disequilibrium and the mapping of complex human traits. Trends Genet (2002) 3.38
Regulatory changes underlying expression differences within and between Drosophila species. Nat Genet (2008) 3.24
Dynamic evolution of the innate immune system in Drosophila. Nat Genet (2007) 3.09
Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01
Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. Curr Biol (2004) 2.84
The history of African gene flow into Southern Europeans, Levantines, and Jews. PLoS Genet (2011) 2.81
Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science (2004) 2.80
Thrice out of Africa: ancient and recent expansions of the honey bee, Apis mellifera. Science (2006) 2.64
Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res (2008) 2.46
Genetic basis of natural variation in D. melanogaster antibacterial immunity. Science (2004) 2.38
Evolution of protein-coding genes in Drosophila. Trends Genet (2008) 2.36
Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol (2007) 2.33
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome. Genetics (2013) 2.17
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics (2003) 2.07
Genome-wide inference of natural selection on human transcription factor binding sites. Nat Genet (2013) 2.03
Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Genetics (2004) 2.01
Population genetics: malaria variorum. Nature (2002) 1.97
Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence. PLoS Genet (2009) 1.97
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics (2005) 1.93
Population genetic structure of the people of Qatar. Am J Hum Genet (2010) 1.91
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One (2007) 1.89
Understanding the accuracy of statistical haplotype inference with sequence data of known phase. Genet Epidemiol (2007) 1.87
Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathog (2007) 1.82
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics (2003) 1.79
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites. Mol Biol Evol (2003) 1.75
The evolutionary costs of immunological maintenance and deployment. BMC Evol Biol (2008) 1.74
Low conservation of gene content in the Drosophila Y chromosome. Nature (2008) 1.72
Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69
Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations. Am J Hum Genet (2003) 1.66
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet (2004) 1.61
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics (2002) 1.57
Conjuring SNPs to detect associations. Nat Genet (2007) 1.57
A genome-wide approach to identifying novel-imprinted genes. Hum Genet (2007) 1.55
Origin and evolution of Y chromosomes: Drosophila tales. Trends Genet (2009) 1.53
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res (2004) 1.52
Identification by full-coverage array CGH of human DNA copy number increases relative to chimpanzee and gorilla. Genome Res (2005) 1.51
Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
Y chromosome and other heterochromatic sequences of the Drosophila melanogaster genome: how far can we go? Genetica (2003) 1.49
Mapping multiple Quantitative Trait Loci by Bayesian classification. Genetics (2004) 1.46
Natural genetic variation in male reproductive genes contributes to nontransitivity of sperm competitive ability in Drosophila melanogaster. Mol Ecol (2012) 1.46
Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster. Genetics (2008) 1.45
Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster. Genetics (2007) 1.45
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria. Genetics (2006) 1.44
Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data. Genetics (2009) 1.42
Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing. Nat Genet (2011) 1.41
Disentangling the relationship between sex-biased gene expression and X-linkage. Genome Res (2012) 1.40
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Res (2005) 1.40
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Am J Hum Genet (2007) 1.39
Robustness of inference of haplotype block structure. J Comput Biol (2003) 1.38
Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol Evol (2009) 1.36
Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet (2010) 1.36
Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. Genetics (2008) 1.33
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Genome sequencing reveals complex speciation in the Drosophila simulans clade. Genome Res (2012) 1.31
Optimal haplotype block-free selection of tagging SNPs for genome-wide association studies. Genome Res (2004) 1.28
Genetic incompatibilities are widespread within species. Nature (2013) 1.28
Larval rearing environment affects several post-copulatory traits in Drosophila melanogaster. Biol Lett (2007) 1.27
Molecular population genetics of inducible antibacterial peptide genes in Drosophila melanogaster. Mol Biol Evol (2003) 1.27
Rehabilitation and the single cell. Curr Opin Cell Biol (2006) 1.26
Neutral genomic regions refine models of recent rapid human population growth. Proc Natl Acad Sci U S A (2013) 1.25
Genes involved in convergent evolution of eusociality in bees. Proc Natl Acad Sci U S A (2011) 1.24
A survey for novel imprinted genes in the mouse placenta by mRNA-seq. Genetics (2011) 1.24
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23