Published in Cancer Res on April 15, 2010
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett (2011) 2.24
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41
Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer. PLoS One (2013) 1.16
Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies. Mol Med (2011) 1.13
Polyphenols: key issues involved in chemoprevention of prostate cancer. Oxid Med Cell Longev (2012) 1.08
Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation. PLoS One (2013) 1.08
Modulation of Wnt/β-catenin signaling pathway by bioactive food components. Carcinogenesis (2011) 1.06
Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One (2010) 1.04
Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin Med (2011) 1.03
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev (2010) 1.00
Aggressive prostate cancer is prevented in ERαKO mice and stimulated in ERβKO TRAMP mice. Endocrinology (2012) 0.96
Resveratrol-based combinatorial strategies for cancer management. Ann N Y Acad Sci (2013) 0.95
Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94
Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. J Biol Chem (2012) 0.93
Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort. Nutr Cancer (2011) 0.92
In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment. Int J Mol Sci (2015) 0.92
Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. PLoS One (2012) 0.90
Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy. Oncogenesis (2015) 0.90
Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Sci Rep (2016) 0.89
Dietary polyphenols in prevention and treatment of prostate cancer. Int J Mol Sci (2015) 0.89
Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis. Oncol Lett (2015) 0.89
Clinical implications of hedgehog signaling pathway inhibitors. Chin J Cancer (2011) 0.88
Future directions in the prevention of prostate cancer. Nat Rev Clin Oncol (2013) 0.88
Hedgehog signaling in skin cancers. Cell Signal (2011) 0.87
Cancer stem cells: potential target for bioactive food components. J Nutr Biochem (2012) 0.86
Hedgehog signaling pathway in ovarian cancer. Int J Mol Sci (2013) 0.82
Effects of quercetin on the proliferation of breast cancer cells and expression of survivin in vitro. Exp Ther Med (2013) 0.82
Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells. Biochim Biophys Acta (2011) 0.81
Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome. Am J Physiol Gastrointest Liver Physiol (2014) 0.80
Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract. Cell Biol Int (2015) 0.80
Novel targets for prostate cancer chemoprevention. Endocr Relat Cancer (2010) 0.80
Effect of quercetin on the proliferation of the human ovarian cancer cell line SKOV-3 in vitro. Exp Ther Med (2015) 0.79
Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. Cancer Cell Int (2015) 0.79
Targeting sonic hedgehog signaling by compounds and derivatives from natural products. Evid Based Complement Alternat Med (2013) 0.79
The tissue-specific stem cell as a target for chemoprevention. Stem Cell Rev (2011) 0.78
Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer. Int J Clin Exp Pathol (2015) 0.78
Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. PLoS One (2015) 0.77
The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. J Oncol (2011) 0.77
Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. BMC Complement Altern Med (2014) 0.77
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype. Cell Death Dis (2016) 0.76
Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents. Anticancer Agents Med Chem (2015) 0.75
Hedgehog signalling pathway: carcinogenesis and targeted therapy. Iran J Cancer Prev (2013) 0.75
Salmonella Bacterial Monotherapy Reduces Autochthonous Prostate Tumor Burden in the TRAMP Mouse Model. PLoS One (2016) 0.75
Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa. Biomed Res Int (2015) 0.75
Quantitative Gene Expression of ERG9 in Model Saccharomyces cerevisiae: Chamomile Extract For Human Cancer Treatment. J Clin Diagn Res (2016) 0.75
Combination chemoprevention with grape antioxidants. Mol Nutr Food Res (2016) 0.75
Facile Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Activities of Biscoumarin Copolyester Bearing Pendant 3-(Trifluoromethyl)Styrene. Int Sch Res Notices (2014) 0.75
Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Evaluation of Copolyester Bearing 4-Arylidene Curcumin in the Main Chain. Int Sch Res Notices (2014) 0.75
Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles. Int J Nanomedicine (2015) 0.75
Quercetin inhibits angiogenesis-mediated human retinoblastoma growth by targeting vascular endothelial growth factor receptor. Oncol Lett (2017) 0.75
Genistein alters methylation patterns in mice. J Nutr (2002) 1.60
Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice. Am J Physiol Heart Circ Physiol (2006) 1.59
The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology (2003) 1.43
Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol (2003) 1.40
Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res (2005) 1.38
Tissue engineering by self-assembly of cells printed into topologically defined structures. Tissue Eng Part A (2008) 1.35
Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Endocrinology (2003) 1.17
Serodiagnosis of mice minute virus and mouse parvovirus infections in mice by enzyme-linked immunosorbent assay with baculovirus-expressed recombinant VP2 proteins. Clin Diagn Lab Immunol (2002) 1.16
Impact on bone of an estrogen receptor-alpha gene loss of function mutation. J Clin Endocrinol Metab (2008) 1.12
Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer (2004) 1.03
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis (2009) 1.02
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation. Reprod Toxicol (2013) 1.01
Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro. J Leukoc Biol (2004) 0.98
Estrogen receptor-alpha mediates estrogen facilitation of baroreflex heart rate responses in conscious mice. Am J Physiol Heart Circ Physiol (2004) 0.98
Aggressive prostate cancer is prevented in ERαKO mice and stimulated in ERβKO TRAMP mice. Endocrinology (2012) 0.96
Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr Cancer (2009) 0.96
Estrogen receptor alpha-mediated events promote sex-specific diabetic glomerular hypertrophy. Am J Physiol Renal Physiol (2004) 0.96
Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta. J Clin Endocrinol Metab (2005) 0.95
Soy isoflavones increase latency of spontaneous mammary tumors in mice. J Nutr (2002) 0.93
Genome-wide analysis of changes in early gene expression induced by oestrogen. Genes Cells (2002) 0.93
Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Mol Reprod Dev (2006) 0.90
Creation and preliminary characterization of a Tp53 knockout rat. Dis Model Mech (2012) 0.90
Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells. J Neuroinflammation (2013) 0.89
Proteomic quantification and site-mapping of S-nitrosylated proteins using isobaric iodoTMT reagents. J Proteome Res (2014) 0.89
Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer. J Nutr (2004) 0.89
Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice. Am J Physiol Endocrinol Metab (2009) 0.88
Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model. Breast Cancer Res Treat (2008) 0.88
Estrogen modulation of baroreflex function in conscious mice. Am J Physiol Regul Integr Comp Physiol (2003) 0.87
Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells. Endocrine (2007) 0.87
ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol (2007) 0.87
Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice. J Steroid Biochem Mol Biol (2005) 0.87
The neuroprotective effects of apocynin. Front Biosci (Elite Ed) (2012) 0.87
Pneumocystis carinii infection causes lung lesions historically attributed to rat respiratory virus. Comp Med (2011) 0.86
Deficient degradation of homotrimeric type I collagen, α1(I)3 glomerulopathy in oim mice. Mol Genet Metab (2011) 0.85
Estrogenic regulation of host immunity against an estrogen receptor-negative human breast cancer. Clin Cancer Res (2006) 0.84
Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo. Endocrine (2007) 0.83
Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice. Mamm Genome (2011) 0.83
Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-alpha-deficient mice. Am J Physiol Heart Circ Physiol (2003) 0.83
Morphological comparison of the testis and efferent ductules between wild-type and estrogen receptor alpha knockout mice during postnatal development. J Anat (2009) 0.82
Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues. Biochemistry (2004) 0.82
Inhibition of hedgehog/Gli signaling by botanicals: a review of compounds with potential hedgehog pathway inhibitory activities. Curr Cancer Drug Targets (2013) 0.80
NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells. J Neuroinflammation (2014) 0.80
Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. Cancer Prev Res (Phila) (2010) 0.79
Expression of a novel C-type lectin in the mouse vagina. Endocrinology (2003) 0.78
Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide. Clin Exp Metastasis (2012) 0.78
Comparison of the mouse antibody production (MAP) assay and polymerase chain reaction (PCR) assays for the detection of viral contaminants. Biologicals (2004) 0.77
Characterization of lymphocyte subsets in the bronchiolar lymph nodes of BALB/c mice infected with cilia-associated respiratory bacillus. Comp Med (2002) 0.77
Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice. Biol Reprod (2009) 0.76
Effects of dietary apigenin on tumor latency, incidence and multiplicity in a medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced breast cancer model. Nutr Cancer (2013) 0.75
Megestrol acetate increases short-term food intake in zinc-deficient rats. Physiol Behav (2002) 0.75
Differential expression of FGF family members in a progestin-dependent BT-474 human breast cancer xenograft model. Histol Histopathol (2012) 0.75
Methoxychlor Stimulates Estrogen-Responsive Messenger Ribonucleic Acids in Mouse Uterus through a Non-Estrogen Receptor (Non-ER)α and Non-ERβ Mechanism. Endocrinology (1999) 0.75
Vitamin A toxicity and vitamin E deficiency in a rabbit colony. Contemp Top Lab Anim Sci (2004) 0.75
Characterization of a novel parainfluenza virus, caviid parainfluenza virus 3, from laboratory guinea pigs (Cavia porcellus). Comp Med (2002) 0.75
Transcription and Translation of Estrogen Receptor-β in the Male Reproductive Tract of Estrogen Receptor-α Knock-Out and Wild-Type Mice. Endocrinology (1998) 0.75
Corrigendum: Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status. Sci Rep (2016) 0.75
The Differential Fate of Mesonephric Tubular-Derived Efferent Ductules in Estrogen Receptor-α Knockout Versus Wild-Type Female Mice. Endocrinology (2000) 0.75