Published in J Biol Chem on April 16, 2010
Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6. J Mol Biol (2013) 1.58
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Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet (2015) 1.10
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The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics (2012) 0.94
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The oncogene ERG: a key factor in prostate cancer. Oncogene (2015) 0.93
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Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. J Neurochem (2011) 0.89
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Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells. Cell Commun Signal (2015) 0.87
Allosteric analysis of glucocorticoid receptor-DNA interface induced by cyclic Py-Im polyamide: a molecular dynamics simulation study. PLoS One (2012) 0.84
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The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. PLoS One (2011) 0.78
The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2. PLoS One (2012) 0.78
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor. Nat Commun (2016) 0.78
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An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc Natl Acad Sci U S A (1992) 1.80
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Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Cell (2004) 1.59
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol (2000) 1.58
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The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochem Biophys Res Commun (1999) 1.41
DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition. J Biol Chem (2000) 1.41
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The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1. EMBO J (1999) 1.36
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The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. J Biol Chem (1998) 1.31
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Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. Nat Struct Biol (2000) 1.25
TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. Mol Cell Biol (2000) 1.24
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor. Proc Natl Acad Sci U S A (2003) 1.20
The ETS domain transcription factor Elk-1 contains a novel class of repression domain. Mol Cell Biol (2002) 1.12
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TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Oncogene (2001) 1.07
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Native interface of the SAM domain polymer of TEL. BMC Struct Biol (2002) 1.03
Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan. Mol Cell Biol (2010) 1.00
Different domains of the transcription factor ELF3 are required in a promoter-specific manner and multiple domains control its binding to DNA. J Biol Chem (2006) 1.00
Diversity in structure and function of the Ets family PNT domains. J Mol Biol (2004) 0.99
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Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL. Oncogene (2000) 0.96
Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Genes Dev (2005) 0.96
Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA. J Mol Biol (2010) 0.94
Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function. Mol Cell Biol (2008) 0.93
Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. EMBO J (2005) 0.93
Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter. Oncogene (1999) 0.86
TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL. J Biol Chem (2003) 0.86
Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. Mol Cell Biol (2008) 0.85
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev (2007) 3.56
Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem (2011) 2.89
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Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res (2004) 2.55
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An NMR approach to structural proteomics. Proc Natl Acad Sci U S A (2002) 1.95
Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol (2004) 1.89
The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing. Bioinformatics (2009) 1.83
An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev (2002) 1.73
Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (2008) 1.62
The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem (2004) 1.62
Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes Dev (2011) 1.56
The solution structure and interactions of CheW from Thermotoga maritima. Nat Struct Biol (2002) 1.41
Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem (2002) 1.25
The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proc Natl Acad Sci U S A (2008) 1.20
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1. Immunity (2012) 1.18
The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region. J Mol Biol (2008) 1.10
Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces. J Mol Biol (2004) 1.08
Structural characterization of Escherichia coli BamE, a lipoprotein component of the β-barrel assembly machinery complex. Biochemistry (2011) 1.08
Protein dielectric constants determined from NMR chemical shift perturbations. J Am Chem Soc (2013) 1.08
Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculations. Proteins (2010) 1.05
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A (2010) 1.01
Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Mol Cell Biol (2004) 0.99
Diversity in structure and function of the Ets family PNT domains. J Mol Biol (2004) 0.99
Inhibitory module of Ets-1 allosterically regulates DNA binding through a dipole-facilitated phosphate contact. J Biol Chem (2001) 0.97
The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells. Genes Cancer (2011) 0.97
Site-specific characterization of the association of xylooligosaccharides with the CBM13 lectin-like xylan binding domain from Streptomyces lividans xylanase 10A by NMR spectroscopy. Biochemistry (2002) 0.96
Direct demonstration of the flexibility of the glycosylated proline-threonine linker in the Cellulomonas fimi Xylanase Cex through NMR spectroscopic analysis. J Biol Chem (2006) 0.95
Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. Biochemistry (2010) 0.95
Arginine: Its pKa value revisited. Protein Sci (2015) 0.94
Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts. Mol Cell Biol (2002) 0.94
Titration_DB: storage and analysis of NMR-monitored protein pH titration curves. Proteins (2010) 0.94
pH-dependent random coil (1)H, (13)C, and (15)N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements. J Biomol NMR (2014) 0.93
Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain. J Mol Biol (2012) 0.93
Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4. J Biol Chem (2002) 0.92
Unambiguous determination of the ionization state of a glycoside hydrolase active site lysine by 1H-15N heteronuclear correlation spectroscopy. J Am Chem Soc (2006) 0.90
A secondary xylan-binding site enhances the catalytic activity of a single-domain family 11 glycoside hydrolase. J Mol Biol (2007) 0.89
Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. J Biol Chem (2004) 0.89
Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J Biol Chem (2005) 0.89
Role of Ets-1 phosphorylation in the effector function of Th cells. Eur J Immunol (2008) 0.88
Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. J Biol Chem (2011) 0.87
Structure-function analysis of a broad specificity Populus trichocarpa endo-β-glucanase reveals an evolutionary link between bacterial licheninases and plant XTH gene products. J Biol Chem (2013) 0.87
Structure, dynamics, and ionization equilibria of the tyrosine residues in Bacillus circulans xylanase. J Biomol NMR (2011) 0.87
Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C. Structure (2010) 0.86
NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base. Biochemistry (2009) 0.86
Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations. J Biomol NMR (2004) 0.86
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet (2010) 0.85
Ets-1 flips for new partner Pax-5. Structure (2002) 0.85
Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy. Biochemistry (2007) 0.84
Determination of electrostatic interaction energies and protonation state populations in enzyme active sites. J Mol Biol (2007) 0.84
Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. Protein Sci (2007) 0.84
A protein export pathway involving Escherichia coli porins. Structure (2012) 0.83
Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation. J Biol Chem (2013) 0.83
A pleckstrin homology-related domain in SHIP1 mediates membrane localization during Fcγ receptor-induced phagocytosis. FASEB J (2012) 0.82
Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. J Mol Biol (2008) 0.82
Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase. Biochemistry (2013) 0.81
Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex. J Am Chem Soc (2006) 0.80
¹H, ¹³C and ¹⁵N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD. Biomol NMR Assign (2012) 0.80
Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy. Biochemistry (2013) 0.79
Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors. J Biomol NMR (2002) 0.79
Detection and assignment of phosphoserine and phosphothreonine residues by (13)C- (31)P spin-echo difference NMR spectroscopy. J Biomol NMR (2008) 0.79
Characterizing the pH-dependent stability and catalytic mechanism of the family 11 xylanase from the alkalophilic Bacillus agaradhaerens. Carbohydr Res (2003) 0.79
The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. J Biol Chem (2012) 0.79
Structural characterization of the C3 domain of cardiac myosin binding protein C and its hypertrophic cardiomyopathy-related R502W mutant. Biochemistry (2014) 0.78
NMR spectroscopic characterization of a beta-(1,4)-glycosidase along its reaction pathway: stabilization upon formation of the glycosyl-enzyme intermediate. Biochemistry (2007) 0.78
Nuclear magnetic resonance spectral assignments of α-1,4-galactosyltransferase LgtC from Neisseria meningitidis: substrate binding and multiple conformational states. Biochemistry (2012) 0.77
Putting a stop to L,D-transpeptidases. Structure (2012) 0.77
Release of membrane-bound vesicles and inhibition of tumor cell adhesion by the peptide Neopetrosiamide A. PLoS One (2010) 0.77
Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. Biochemistry (2007) 0.77
The PNT domain from Drosophila pointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence. Protein Sci (2012) 0.76
Dissecting the domain structure of Cdc4p, a myosin essential light chain involved in Schizosaccharomyces pombe cytokinesis. Biochemistry (2005) 0.76
Dual views of SRF: a genomic exposure. Genes Dev (2014) 0.76
Backbone chemical shift assignments of the LexA catalytic domain in its active conformation. J Biomol NMR (2005) 0.76
Glycosynthase-based synthesis of xylo-oligosaccharides using an engineered retaining xylanase from Cellulomonas fimi. Org Biomol Chem (2006) 0.75
Detection and characterization of serine and threonine hydroxyl protons in Bacillus circulans xylanase by NMR spectroscopy. J Biomol NMR (2013) 0.75
Phage display and crystallographic analysis reveals potential substrate/binding site interactions in the protein secretion chaperone CsaA from Agrobacterium tumefaciens. J Mol Biol (2008) 0.75