The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.

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Published in PLoS One on June 23, 2014

Authors

Qi-Liang Mao-Ying1, Annemieke Kavelaars2, Karen Krukowski2, Xiao-Jiao Huo2, Wenjun Zhou2, Theodore J Price3, Charles Cleeland4, Cobi J Heijnen2

Author Affiliations

1: Neuroimmunology Laboratory, Department of Symptom Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America; Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
2: Neuroimmunology Laboratory, Department of Symptom Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.
3: School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas, United States of America.
4: Department of Symptom Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.

Associated clinical trials:

Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN) | NCT04780854

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