Published in PLoS One on April 19, 2010
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
A systems model for immune cell interactions unravels the mechanism of inflammation in human skin. PLoS Comput Biol (2010) 1.07
Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model. Surg Infect (Larchmt) (2012) 0.95
Digestion of Protein in Premature and Term Infants. J Nutr Disord Ther (2012) 0.93
Translational applications of evaluating physiologic variability in human endotoxemia. J Clin Monit Comput (2012) 0.90
Pathogenesis of necrotizing enterocolitis: modeling the innate immune response. Am J Pathol (2014) 0.88
ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections. IEEE Trans Nanobioscience (2012) 0.87
Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxid Redox Signal (2015) 0.87
Sepsis: from pattern to mechanism and back. Crit Rev Biomed Eng (2012) 0.87
Investigation of inflammation and tissue patterning in the gut using a Spatially Explicit General-purpose Model of Enteric Tissue (SEGMEnT). PLoS Comput Biol (2014) 0.81
Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis. J Theor Biol (2012) 0.79
A three-dimensional mathematical and computational model of necrotizing enterocolitis. J Theor Biol (2012) 0.78
Modelling the interaction between the host immune response, bacterial dynamics and inflammatory damage in comparison with immunomodulation and vaccination experiments. Math Med Biol (2014) 0.75
Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience. Interface Focus (2014) 0.75
Combining Theoretical and Experimental Techniques to Study Murine Heart Transplant Rejection. Front Immunol (2016) 0.75
Commensal host-bacterial relationships in the gut. Science (2001) 14.82
The danger model: a renewed sense of self. Science (2002) 13.85
Breast milk and neonatal necrotising enterocolitis. Lancet (1991) 6.38
Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol (2010) 5.57
Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr (2005) 3.26
Lactobacillus sepsis associated with probiotic therapy. Pediatrics (2005) 3.02
Modulation of colonic barrier function by the composition of the commensal flora in the rat. Gut (2001) 2.46
Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics (2008) 2.23
Translational systems biology of inflammation. PLoS Comput Biol (2008) 2.15
Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev (2008) 1.93
Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention. Semin Perinatol (2008) 1.90
The acute inflammatory response in diverse shock states. Shock (2005) 1.83
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol (2009) 1.83
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol (2006) 1.68
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol (2006) 1.65
The dynamics of acute inflammation. J Theor Biol (2004) 1.60
Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics (1999) 1.59
Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate (2002) 1.59
Cytokines in necrotizing enterocolitis. Shock (2006) 1.53
Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock (2004) 1.46
Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis (1999) 1.45
Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy. J Pediatr Gastroenterol Nutr (2006) 1.44
Mechanistic simulations of inflammation: current state and future prospects. Math Biosci (2008) 1.40
Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr Res (2008) 1.34
State-based analysis of necrotizing enterocolitis outcomes. J Surg Res (2008) 1.28
The use of human milk for premature infants. Pediatr Clin North Am (2001) 1.23
Neonatal necrotizing enterocolitis: experience with 100 consecutive surgical patients. World J Surg (1990) 1.23
Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol (2010) 1.18
Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient. J Burn Care Res (2008) 1.17
Bacterial colonization, probiotics, and necrotizing enterocolitis. J Clin Gastroenterol (2008) 1.14
A mathematical simulation of the inflammatory response to anthrax infection. Shock (2008) 1.11
Concern Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun (2008) 1.06
Probiotics for preterm infants? Arch Dis Child Fetal Neonatal Ed (2003) 1.00
Effect of probiotics on enterocyte bacterial translocation in vitro. Pediatr Surg Int (2001) 0.93
Probiotics for necrotizing enterocolitis: a systematic review. J Pediatr Gastroenterol Nutr (2007) 0.90
Operative strategies for necrotizing enterocolitis: The prevention and treatment of short-bowel syndrome. Semin Pediatr Surg (2005) 0.87
Classification, epidemiology and aetiology. Best Pract Res Clin Gastroenterol (2003) 0.87
Intestinal obstruction due to colonic stricture following neonatal necrotizing enterocolitis. Ann Surg (1980) 0.85
The danger is growing! A new paradigm for immune system activation and peripheral tolerance. PLoS One (2009) 0.78
Mucosal barrier function and the commensal flora. Gut (2002) 0.78
Probiotics and neonatal intestinal infection. Curr Opin Infect Dis (2006) 0.76
Phase-response curves give the responses of neurons to transient inputs. J Neurophysiol (2005) 2.15
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol (2007) 2.02
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology (2009) 1.98
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun (2002) 1.85
Correlation-induced synchronization of oscillations in olfactory bulb neurons. J Neurosci (2006) 1.84
The acute inflammatory response in diverse shock states. Shock (2005) 1.83
Efficient estimation of phase-resetting curves in real neurons and its significance for neural-network modeling. Phys Rev Lett (2005) 1.80
In silico design of clinical trials: a method coming of age. Crit Care Med (2004) 1.78
Nitric oxide and wound repair: role of cytokines? Nitric Oxide (2002) 1.73
Agent-based models in translational systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 1.70
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med (2012) 1.69
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol (2006) 1.68
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol (2006) 1.65
The dynamics of acute inflammation. J Theor Biol (2004) 1.60
Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest (2015) 1.58
Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Crit Care Med (2015) 1.58
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg (2006) 1.57
Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model. J Neurophysiol (2008) 1.57
Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med (2014) 1.57
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated? J Surg Res (2012) 1.53
Phase-response curves and synchronized neural networks. Philos Trans R Soc Lond B Biol Sci (2010) 1.44
Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. Int Urol Nephrol (2009) 1.41
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med (2005) 1.40
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol (2006) 1.40
Consider the children: pediatric disaster planning. Nurs Manage (2013) 1.39
Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen (2007) 1.39
A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS One (2008) 1.38
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol (2009) 1.36
Multiple rhythmic states in a model of the respiratory central pattern generator. J Neurophysiol (2009) 1.35
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (2013) 1.35
Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr Res (2008) 1.34
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol (2007) 1.31
Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia. J Neurosci (2011) 1.30
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
State-based analysis of necrotizing enterocolitis outcomes. J Surg Res (2008) 1.28
Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg (2005) 1.26
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med (2006) 1.25
Class-II neurons display a higher degree of stochastic synchronization than class-I neurons. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.25
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. PLoS One (2011) 1.24
Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Curr Mol Med (2004) 1.21
Testing Turing's theory of morphogenesis in chemical cells. Proc Natl Acad Sci U S A (2014) 1.20
Optimal time scale for spike-time reliability: theory, simulations, and experiments. J Neurophysiol (2007) 1.19
Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient. J Burn Care Res (2008) 1.17
Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock (2008) 1.15
Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect Immun (2003) 1.14
Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis. J Infect Dis (2008) 1.14
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol (2005) 1.12
Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock (2008) 1.12
Translational systems biology of inflammation: potential applications to personalized medicine. Per Med (2010) 1.11
A mathematical simulation of the inflammatory response to anthrax infection. Shock (2008) 1.11
Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol (2003) 1.10
Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology (2002) 1.08
Necrotizing enterocolitis--bench to bedside: novel and emerging strategies. Semin Pediatr Surg (2008) 1.08
Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock (2009) 1.07
Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology (2008) 1.07
The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology (2012) 1.07
Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol (2006) 1.07
Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol (2009) 1.07
Concern Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun (2008) 1.06
Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis. J Comput Neurosci (2009) 1.05
An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. PLoS One (2009) 1.05
Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS One (2013) 1.04
An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reduction. J Theor Biol (2008) 1.04
Models of lower extremity damage in mice: time course of organ damage and immune response. J Surg Res (2010) 1.04
Interactions of persistent sodium and calcium-activated nonspecific cationic currents yield dynamically distinct bursting regimes in a model of respiratory neurons. J Comput Neurosci (2011) 1.04
Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans. Ann Surg (2016) 1.03
The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol (2008) 1.03
Spike generating dynamics and the conditions for spike-time precision in cortical neurons. J Comput Neurosci (2003) 1.03
Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Mol Med (2012) 1.03
An introduction to simulation and visualization of biological systems at multiple scales: a summer training program for interdisciplinary research. Biotechnol Prog (2006) 1.02
Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. J Trauma Acute Care Surg (2012) 1.02
The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Hepatology (2005) 1.01
The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery (2004) 1.00
A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice. Pancreas (2004) 1.00
Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams. J Crit Care (2007) 1.00
A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Math Biosci (2008) 1.00
Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure. Ann Biomed Eng (2012) 1.00
Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect. Biochem Biophys Res Commun (2007) 0.99
Computational and systems biology in trauma and sepsis: current state and future perspectives. Int J Burns Trauma (2012) 0.99
Intrinsic heterogeneity in oscillatory dynamics limits correlation-induced neural synchronization. J Neurophysiol (2012) 0.99
The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. J Orthop Trauma (2008) 0.99
Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. PLoS One (2013) 0.98
Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs. JAMA Surg (2013) 0.98
An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math Biosci (2011) 0.98
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol (2012) 0.96
Stochastic dynamics of uncoupled neural oscillators: Fokker-Planck studies with the finite element method. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 0.96
Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock (2007) 0.96
Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock (2005) 0.96
Synchronization dynamics of two coupled neural oscillators receiving shared and unshared noisy stimuli. J Comput Neurosci (2008) 0.95
Finite-size and correlation-induced effects in mean-field dynamics. J Comput Neurosci (2011) 0.95
P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab Invest (2011) 0.95
Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. Shock (2003) 0.95
Role of nitric oxide and peroxynitrite in gut barrier failure. World J Surg (2002) 0.95
Smartphones, trainees, and mobile education: implications for graduate medical education. J Grad Med Educ (2014) 0.95
A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: I. Rhythm generation. J Neural Eng (2011) 0.95
Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. Cancer Res (2004) 0.94