Published in Oncogene on September 12, 2002
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Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res (2009) 2.28
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
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Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res (2009) 1.65
The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol (2003) 1.44
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle (2014) 1.05
Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell (2011) 0.99
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Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. J Biol Chem (2010) 0.91
Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. Front Biol (Beijing) (2014) 0.90
Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett (2007) 0.87
Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence. Mol Cell Biol (2013) 0.84
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle (2016) 0.83
Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen (2014) 0.83
Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells. PLoS One (2013) 0.82
MicroRNAs Regulate Key Effector Pathways of Senescence. J Aging Res (2011) 0.82
Epigenetic changes during cell transformation. Adv Exp Med Biol (2013) 0.81
Redox control of senescence and age-related disease. Redox Biol (2016) 0.79
Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway. PLoS One (2010) 0.79
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Multiple facets of p53 in senescence induction and maintenance. Cancer Sci (2016) 0.79
Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length. Genome Integr (2013) 0.78
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol (2012) 0.77
Initiation of premature senescence by Bcl-2 in hypoxic condition. Int J Clin Exp Pathol (2014) 0.75
MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS One (2015) 0.75
Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses? Cell Mol Life Sci (2017) 0.75
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
In situ analyses of genome instability in breast cancer. Nat Genet (2004) 4.32
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature (2011) 3.53
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell (2011) 2.78
PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med (2008) 2.56
Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One (2010) 2.55
Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res (2009) 2.28
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A (2012) 2.20
Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem (2007) 1.88
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med (2012) 1.85
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res (2006) 1.69
Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res (2009) 1.65
Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol (2005) 1.64
Telomerase activation by c-Myc in human mammary epithelial cells requires additional genomic changes. Cell Cycle (2009) 1.52
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol (2005) 1.45
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. Cell Cycle (2007) 1.40
Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett (2003) 1.38
Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol (2006) 1.36
Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. Int J Biochem Cell Biol (2002) 1.32
Epigenetic regulation of normal human mammary cell type-specific miRNAs. Genome Res (2011) 1.27
Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. Biochim Biophys Acta (2007) 1.27
ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. Hum Mol Genet (2005) 1.25
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Mol Cancer (2007) 1.24
Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Res (2012) 1.20
Genetic basis of congenital erythrocytosis: mutation update and online databases. Hum Mutat (2013) 1.18
p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18
miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer. PLoS One (2013) 1.17
Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev (2010) 1.14
Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene (2003) 1.13
Multidimensional profiling of cell surface proteins and nuclear markers. IEEE/ACM Trans Comput Biol Bioinform (2010) 1.13
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.11
The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells. Cell Cycle (2012) 1.10
Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A). Mol Cell (2010) 1.08
Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Res (2009) 1.08
The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov (2012) 1.06
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle (2014) 1.05
Aging and cancer cell biology, 2009. Aging Cell (2009) 1.04
Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer. Cancer Epidemiol Biomarkers Prev (2012) 1.03
The regulation of SOX7 and its tumor suppressive role in breast cancer. Am J Pathol (2013) 0.99
Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8- immature thymocytes. J Immunol (2002) 0.97
ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. Mol Cancer Res (2006) 0.95
Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. Genes Chromosomes Cancer (2013) 0.92
Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia. Haematologica (2011) 0.92
Processing of human reduction mammoplasty and mastectomy tissues for cell culture. J Vis Exp (2013) 0.92
Cellular senescence mediated by p16INK4A-coupled miRNA pathways. Nucleic Acids Res (2013) 0.90
Von Hippel-Lindau: how a rare disease illuminates cancer biology. Semin Cancer Biol (2012) 0.90
Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene (2005) 0.89
No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome. Fam Cancer (2010) 0.89
Identification of TET1 Partners That Control Its DNA-Demethylating Function. Genes Cancer (2013) 0.88
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell (2010) 0.88
Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res (2010) 0.88
BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. PLoS One (2010) 0.88
Crystal structure of human calmodulin-like protein: insights into its functional role. FEBS Lett (2002) 0.85
Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models. Aging Cell (2005) 0.84
Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors. Breast Cancer Res (2011) 0.84
Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. Cell Cycle (2007) 0.83
Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation. Radiat Res (2008) 0.82
Cell-type specific DNA methylation patterns define human breast cellular identity. PLoS One (2012) 0.82
A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene. Haematologica (2008) 0.81
Corrigendum: A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature (2015) 0.75
Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells. Environ Health Perspect (2015) 0.75
[Genetics and angiogenesis: the example of von Hippel-Lindau disease]. Bull Cancer (2007) 0.75