Published in Mol Biol Cell on May 12, 2010
A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell (2011) 1.32
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr (2011) 1.31
GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem (2015) 1.27
Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal (2011) 1.20
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J (2010) 1.19
Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell (2012) 1.15
STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem (2012) 1.09
GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun (2014) 1.05
Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proc Natl Acad Sci U S A (2013) 1.02
Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci U S A (2012) 1.01
GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. J Am Soc Nephrol (2014) 1.01
Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene (2011) 1.00
Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell (2014) 0.98
Involvement of Girdin in the determination of cell polarity during cell migration. PLoS One (2012) 0.98
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad. Mol Pharmacol (2013) 0.93
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife (2015) 0.90
Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A (2015) 0.90
Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A (2015) 0.89
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Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling. Dev Cell (2015) 0.86
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Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. Mol Biol Cell (2015) 0.83
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Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol (2015) 0.82
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CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res (2016) 0.78
GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells. J Biol Chem (2016) 0.78
AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. Elife (2016) 0.78
Girdin expression in cervical carcinoma and its role in the malignant properties of HeLa cells. Oncol Lett (2016) 0.78
GIV/Girdin activates Gαi and inhibits Gαs via the same motif. Proc Natl Acad Sci U S A (2016) 0.78
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The essential role of Giα2 in prostate cancer cell migration. Mol Cancer Res (2012) 0.78
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