Published in Proc Natl Acad Sci U S A on February 02, 2010
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
Functional and mechanistic diversity of distal transcription enhancers. Cell (2011) 5.22
CTCF: an architectural protein bridging genome topology and function. Nat Rev Genet (2014) 3.64
Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell (2012) 3.08
Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation. Nucleic Acids Res (2010) 2.96
Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc Natl Acad Sci U S A (2013) 2.71
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell (2015) 2.59
Condensin and cohesin complexity: the expanding repertoire of functions. Nat Rev Genet (2010) 2.49
Cohesin: genomic insights into controlling gene transcription and development. Curr Opin Genet Dev (2011) 2.12
Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev (2010) 1.88
Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev (2011) 1.88
Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell (2012) 1.85
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev (2010) 1.76
Cohesin organizes chromatin loops at DNA replication factories. Genes Dev (2010) 1.71
In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney Int (2012) 1.67
Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring. J Cell Biol (2011) 1.66
Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell (2014) 1.64
Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide. Mol Syst Biol (2010) 1.59
Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res (2012) 1.58
Cohesinopathies, gene expression, and chromatin organization. J Cell Biol (2010) 1.55
Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling. PLoS Comput Biol (2014) 1.52
Chromatin insulators: linking genome organization to cellular function. Mol Cell (2013) 1.51
The ancient and evolving roles of cohesin in gene expression and DNA repair. Curr Biol (2012) 1.49
Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast. Nat Genet (2016) 1.44
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. PLoS One (2011) 1.38
A unique role of cohesin-SA1 in gene regulation and development. EMBO J (2012) 1.38
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Dynamic trans-acting factor colocalization in human cells. Cell (2013) 1.31
Cohesin selectively binds and regulates genes with paused RNA polymerase. Curr Biol (2011) 1.30
In the loop: long range chromatin interactions and gene regulation. Brief Funct Genomics (2011) 1.30
Cohesin mediates chromatin interactions that regulate mammalian β-globin expression. J Biol Chem (2011) 1.29
Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation. J Biol Chem (2012) 1.25
Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub. Nucleic Acids Res (2013) 1.14
CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization. Nucleic Acids Res (2012) 1.13
Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines. PLoS Comput Biol (2012) 1.12
Do chromatin loops provide epigenetic gene expression states? Curr Opin Genet Dev (2010) 1.12
The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther (2011) 1.11
An Overview of Genome Organization and How We Got There: from FISH to Hi-C. Microbiol Mol Biol Rev (2015) 1.10
Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements. Epigenetics Chromatin (2014) 1.09
Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease. PLoS One (2012) 1.08
The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome. Hum Mol Genet (2012) 1.06
Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies. Front Genet (2012) 1.06
Nuclear organization: taking a position on gene expression. Curr Opin Cell Biol (2011) 1.04
Tissue-specific regulation of chromatin insulator function. PLoS Genet (2012) 1.03
ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder. Methods Mol Biol (2012) 1.03
Chromatin loops, gene positioning, and gene expression. Front Genet (2012) 1.03
Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes. BMC Genomics (2013) 1.03
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin. Genome Res (2015) 1.02
ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Nat Commun (2015) 1.01
Chromatin insulators: a role in nuclear organization and gene expression. Adv Cancer Res (2011) 1.01
CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus. Nucleic Acids Res (2012) 0.98
Importance of the matriline for genomic imprinting, brain development and behaviour. Philos Trans R Soc Lond B Biol Sci (2013) 0.98
Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies. Biochim Biophys Acta (2013) 0.97
DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics (2013) 0.97
Chromatin loop formation in the β-globin locus and its role in globin gene transcription. Mol Cells (2012) 0.94
Scc2 regulates gene expression by recruiting cohesin to the chromosome as a transcriptional activator during yeast meiosis. Mol Biol Cell (2011) 0.93
Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. J Immunol (2013) 0.93
Unravelling global genome organization by 3C-seq. Semin Cell Dev Biol (2011) 0.92
CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation. Nucleic Acids Res (2013) 0.92
Enhancer-promoter communication and transcriptional regulation of Igh. Trends Immunol (2011) 0.92
Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology (2011) 0.91
Achieving singularity in mammalian odorant receptor gene choice. Chem Senses (2010) 0.90
An insulator embedded in the chicken α-globin locus regulates chromatin domain configuration and differential gene expression. Nucleic Acids Res (2010) 0.90
Shaping the Genome with Non-Coding RNAs. Curr Genomics (2011) 0.90
Targeted sister chromatid cohesion by Sir2. PLoS Genet (2011) 0.89
Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (2010) 0.89
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell (2015) 0.89
Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. Nucleic Acids Res (2015) 0.88
Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus. Nucleic Acids Res (2014) 0.88
Cohesin is required for activation of MYC by estradiol. PLoS One (2012) 0.87
Drosophila dosage compensation: males are from Mars, females are from Venus. Fly (Austin) (2011) 0.87
Throwing transcription for a loop: expression of the genome in the 3D nucleus. Chromosoma (2011) 0.86
Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation. Genome Biol Evol (2013) 0.86
Centromeric motion facilitates the mobility of interphase genomic regions in fission yeast. J Cell Sci (2013) 0.85
Higher-order orchestration of hematopoiesis: is cohesin a new player? Exp Hematol (2012) 0.85
Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis. Cell Death Dis (2013) 0.84
SUMO-activating SAE1 transcription is positively regulated by Myc. Am J Cancer Res (2012) 0.84
Cohesin: a critical chromatin organizer in mammalian gene regulation. Biochem Cell Biol (2011) 0.84
Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains. Nucleic Acids Res (2016) 0.84
High-resolution analysis of cis-acting regulatory networks at the α-globin locus. Philos Trans R Soc Lond B Biol Sci (2013) 0.83
Identifying and characterizing regulatory sequences in the human genome with chromatin accessibility assays. Genes (Basel) (2012) 0.83
Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome. Cell Cycle (2011) 0.83
Initiation and maintenance of pluripotency gene expression in the absence of cohesin. Genes Dev (2015) 0.83
Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models. Genome Biol (2016) 0.82
Proteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes. J Proteome Res (2012) 0.82
Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol (2014) 0.81
Inter-chromosomal contact networks provide insights into Mammalian chromatin organization. PLoS One (2015) 0.81
SMC complexes link gene expression and genome architecture. Curr Opin Genet Dev (2014) 0.80
A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila. Nucleic Acids Res (2014) 0.80
A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood (2012) 0.80
Embryonic stem cell specific "master" replication origins at the heart of the loss of pluripotency. PLoS Comput Biol (2015) 0.80
The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Res (2015) 0.80
Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One (2014) 0.79
Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. J Biol Chem (2013) 0.78
Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation. Biochim Biophys Acta (2012) 0.78
Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression. Oncogene (2015) 0.78
Cohesin in oocytes-tough enough for Mammalian meiosis? Genes (Basel) (2010) 0.77
Targeting CTCF to Control Virus Gene Expression: A Common Theme amongst Diverse DNA Viruses. Viruses (2015) 0.77
Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability. Nucleic Acids Res (2015) 0.76
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
CTCF: master weaver of the genome. Cell (2009) 15.09
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet (2006) 11.02
Nuclear organization of the genome and the potential for gene regulation. Nature (2007) 8.22
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science (2006) 7.68
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. EMBO J (2008) 4.28
Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays. Methods Enzymol (2006) 3.53
A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PLoS Biol (2009) 2.89
Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol (2002) 2.69
An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J (1999) 2.68
Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes Dev (2009) 2.58
Boundary elements and nuclear organization. Biol Cell (2004) 2.48
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39
Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter. Mol Cell (2001) 2.32
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol (2009) 2.20
CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90
Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood (1998) 1.68
Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood (2006) 1.65
A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region. Genomics (1998) 1.28
A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus. Proc Natl Acad Sci U S A (2000) 1.23
Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression. PLoS One (2009) 1.05
Chromatin insulators and cohesins. EMBO Rep (2008) 0.89
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol (2006) 2.68
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene. Nucleic Acids Res (2004) 2.11
CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90
Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev (2011) 1.88
BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proc Natl Acad Sci U S A (2009) 1.65
Enhancers: five essential questions. Nat Rev Genet (2013) 1.46
Developmental stage differences in chromatin subdomains of the beta-globin locus. Proc Natl Acad Sci U S A (2004) 1.41
Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood (2010) 1.27
A human globin enhancer causes both discrete and widespread alterations in chromatin structure. Mol Cell Biol (2003) 1.25
Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood (2009) 1.15
Epigenetics of beta-globin gene regulation. Mutat Res (2008) 1.15
Enhancer blocking by chicken beta-globin 5'-HS4: role of enhancer strength and insulator nucleosome depletion. J Biol Chem (2006) 1.11
Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood (2011) 1.05
Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood (2013) 1.05
The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation. Blood (2012) 1.04
A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med (2010) 1.03
Beta-globin intergenic transcription and histone acetylation dependent on an enhancer. Mol Cell Biol (2007) 1.00
Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites. Nucleic Acids Res (2007) 0.99
A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter. Proc Natl Acad Sci U S A (2003) 0.99
CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus. Nucleic Acids Res (2012) 0.98
Chromatin loop formation in the β-globin locus and its role in globin gene transcription. Mol Cells (2012) 0.94
Organizing the genome: enhancers and insulators. Biochem Cell Biol (2005) 0.92
The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Nucleic Acids Res (2014) 0.92
The role of transcriptional activator GATA-1 at human beta-globin HS2. Nucleic Acids Res (2008) 0.88
Beta-globin locus control region HS2 and HS3 interact structurally and functionally. Nucleic Acids Res (2003) 0.86
Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood (2009) 0.83
Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation. Biochim Biophys Acta (2012) 0.78
Monitoring the effects of chromatin remodelers on long-range interactions in vivo. Methods Mol Biol (2012) 0.77
Insulators organize chromatin: emerging rules of the game. Mol Cell (2011) 0.77
A journey towards a healthy collaborative nursing program: a case study. Nurs Leadersh (Tor Ont) (2008) 0.75