Published in Science on May 20, 2010
Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol (2011) 1.45
Lessons learned from quantitative dynamical modeling in systems biology. PLoS One (2013) 1.28
Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses. Front Immunol (2012) 1.14
Experimental design for parameter estimation of gene regulatory networks. PLoS One (2012) 1.03
Statistical analysis of nonlinear dynamical systems using differential geometric sampling methods. Interface Focus (2011) 1.02
T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks. Elife (2014) 1.02
Structural and functional protein network analyses predict novel signaling functions for rhodopsin. Mol Syst Biol (2011) 0.95
Emerging EPO and EPO receptor regulators and signal transducers. Blood (2015) 0.93
Dynamic ligand modulation of EPO receptor pools, and dysregulation by polycythemia-associated EPOR alleles. PLoS One (2012) 0.93
Bayesian model selection validates a biokinetic model for zirconium processing in humans. BMC Syst Biol (2012) 0.92
Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling. Nat Commun (2012) 0.87
A method for zooming of nonlinear models of biochemical systems. BMC Syst Biol (2011) 0.85
Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range. Proc Natl Acad Sci U S A (2014) 0.83
Multifarious determinants of cytokine receptor signaling specificity. Adv Immunol (2014) 0.83
Widespread expression of erythropoietin receptor in brain and its induction by injury. Mol Med (2015) 0.83
Non-erythroid effects of erythropoietin. Haematologica (2010) 0.83
Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep. Biopharm Drug Dispos (2011) 0.81
Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis. Expert Opin Ther Targets (2015) 0.81
In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems. BMC Syst Biol (2012) 0.80
A computational model of liver iron metabolism. PLoS Comput Biol (2013) 0.80
A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways. PLoS Comput Biol (2013) 0.79
Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model. Nucleic Acids Res (2014) 0.79
Prognostic significance of erythropoietin in pancreatic adenocarcinoma. PLoS One (2011) 0.78
Governing Roles for Trib3 Pseudokinase During Stress Erythropoiesis. Exp Hematol (2017) 0.78
Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy. Drug Metab Dispos (2011) 0.77
Physiologically realistic and validated mathematical liver model reveals [corrected] hepatobiliary transfer rates for Gd-EOB-DTPA using human DCE-MRI data. PLoS One (2014) 0.76
Quantification of degeneracy in biological systems for characterization of functional interactions between modules. J Theor Biol (2012) 0.76
Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs. Cell Syst (2016) 0.76
Impact of host genetic polymorphisms on vaccine induced antibody response. Hum Vaccin Immunother (2016) 0.75
L1 regularization facilitates detection of cell type-specific parameters in dynamical systems. Bioinformatics (2016) 0.75
Cumulative signal transmission in nonlinear reaction-diffusion networks. PLoS One (2013) 0.75
Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells. PLoS Comput Biol (2016) 0.75
Driving the Model to Its Limit: Profile Likelihood Based Model Reduction. PLoS One (2016) 0.75
Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment. Haematologica (2012) 0.75
Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation. Mol Syst Biol (2017) 0.75
iVUN: interactive Visualization of Uncertain biochemical reaction Networks. BMC Bioinformatics (2013) 0.75
A dimeric peptide with erythropoiesis-stimulating activity uniquely affects erythropoietin receptor ligation and cell surface expression. Exp Hematol (2016) 0.75
LASSIM-A network inference toolbox for genome-wide mechanistic modeling. PLoS Comput Biol (2017) 0.75
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism. Science (2006) 3.36
Design principles of a bacterial signalling network. Nature (2005) 3.28
Systems biology: experimental design. FEBS J (2009) 2.44
A mouse model for visualization and conditional mutations in the erythroid lineage. Blood (2004) 2.41
Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood (2006) 2.36
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Dynamical modeling and multi-experiment fitting with PottersWheel. Bioinformatics (2008) 2.22
Boron-toxicity tolerance in barley arising from efflux transporter amplification. Science (2007) 2.19
Estimating the annotation error rate of curated GO database sequence annotations. BMC Bioinformatics (2007) 2.11
Control of plant organ size by KLUH/CYP78A5-dependent intercellular signaling. Dev Cell (2007) 1.80
An atlas of gene expression from seed to seed through barley development. Funct Integr Genomics (2006) 1.79
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol Syst Biol (2009) 1.77
Automated methods of predicting the function of biological sequences using GO and BLAST. BMC Bioinformatics (2005) 1.73
Oscillatory cerebral hemodynamics--the macro- vs. microvascular level. J Neurol Sci (2006) 1.67
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res (2009) 1.65
Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol Cell (2011) 1.55
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. Mol Cell (2004) 1.48
Likelihood based observability analysis and confidence intervals for predictions of dynamic models. BMC Syst Biol (2012) 1.45
Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol (2011) 1.45
A common strategy and database to compare the performance of seizure prediction algorithms. Epilepsy Behav (2009) 1.43
Hybrid optimization method with general switching strategy for parameter estimation. BMC Syst Biol (2008) 1.41
Discovery of barley miRNAs through deep sequencing of short reads. BMC Genomics (2011) 1.40
The transcript composition of egg cells changes significantly following fertilization in wheat (Triticum aestivum L.). Plant J (2005) 1.38
Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge. BMC Syst Biol (2007) 1.34
Cell-specific vacuolar calcium storage mediated by CAX1 regulates apoplastic calcium concentration, gas exchange, and plant productivity in Arabidopsis. Plant Cell (2011) 1.32
A quantitative and dynamic model for plant stem cell regulation. PLoS One (2008) 1.32
Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol (2009) 1.31
Assessing the strength of directed influences among neural signals using renormalized partial directed coherence. J Neurosci Methods (2009) 1.31
Joining forces of Bayesian and frequentist methodology: a study for inference in the presence of non-identifiability. Philos Trans A Math Phys Eng Sci (2012) 1.30
Lessons learned from quantitative dynamical modeling in systems biology. PLoS One (2013) 1.28
Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. Br J Haematol (2005) 1.26
Testing for directed influences among neural signals using partial directed coherence. J Neurosci Methods (2005) 1.26
Testing statistical significance of multivariate time series analysis techniques for epileptic seizure prediction. Chaos (2006) 1.26
Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. Hepatology (2010) 1.25
Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension. Neuroimage (2009) 1.25
Photoconversion and nuclear trafficking cycles determine phytochrome A's response profile to far-red light. Cell (2011) 1.23
Effects of attention and precision of exerted force on beta range EEG-EMG synchronization during a maintained motor contraction task. Clin Neurophysiol (2002) 1.23
A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells. Nucleic Acids Res (2013) 1.22
Single nucleotide polymorphism discovery from wheat next-generation sequence data. Plant Biotechnol J (2012) 1.22
Microarray expression analysis of meiosis and microsporogenesis in hexaploid bread wheat. BMC Genomics (2006) 1.21
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood (2008) 1.20
Two-dimensional patterning by a trapping/depletion mechanism: the role of TTG1 and GL3 in Arabidopsis trichome formation. PLoS Biol (2008) 1.19
Comparative transcriptomics in the Triticeae. BMC Genomics (2009) 1.19
Functional diversity of R3 single-repeat genes in trichome development. Development (2009) 1.18
Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res (2013) 1.17
Joining the benefits: combining epileptic seizure prediction methods. Epilepsia (2010) 1.16
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab (2008) 1.15
Computational processing and error reduction strategies for standardized quantitative data in biological networks. FEBS J (2005) 1.13
An integrative model for phytochrome B mediated photomorphogenesis: from protein dynamics to physiology. PLoS One (2010) 1.12
Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL. Blood (2011) 1.09
Gene profiling of polycystic kidneys. Nephrol Dial Transplant (2006) 1.09
Boron toxicity tolerance in barley through reduced expression of the multifunctional aquaporin HvNIP2;1. Plant Physiol (2010) 1.09
The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper. J Biol Chem (2003) 1.08
Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. Mol Syst Biol (2010) 1.08
Partial phase synchronization for multivariate synchronizing systems. Phys Rev Lett (2006) 1.07
Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach. BMC Syst Biol (2014) 1.06
Comparison of approaches for parameter identifiability analysis of biological systems. Bioinformatics (2014) 1.06
The virtual liver: state of the art and future perspectives. Arch Toxicol (2014) 1.05
Transcriptome-scale homoeolog-specific transcript assemblies of bread wheat. BMC Genomics (2012) 1.05
Root-specific transcript profiling of contrasting rice genotypes in response to salinity stress. Mol Plant (2010) 1.04
A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens. J Mol Med (Berl) (2008) 1.04
Dichotomy in the NRT gene families of dicots and grass species. PLoS One (2010) 1.04
Dynamic pathway modeling: feasibility analysis and optimal experimental design. Ann N Y Acad Sci (2007) 1.04
Corticomuscular coherence in the 6-15 Hz band: is the cortex involved in the generation of physiologic tremor? Exp Brain Res (2001) 1.03
Cerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis. Cerebrovasc Dis (2008) 1.03
Experimental design for parameter estimation of gene regulatory networks. PLoS One (2012) 1.03
The EPILEPSIAE database: an extensive electroencephalography database of epilepsy patients. Epilepsia (2012) 1.02
Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease. J Neurol (2008) 1.01
Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem (2011) 1.01
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol (2013) 1.01
A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves. Mol Syst Biol (2008) 1.00
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol Biol Cell (2006) 1.00
Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis (2012) 0.99
Effects of telomerase modulation in human hematopoietic progenitor cells. Stem Cells (2004) 0.98
Secondary decline of cerebral autoregulation is associated with worse outcome after intracerebral hemorrhage. Intensive Care Med (2009) 0.98
Flt-2L, a locus in barley controlling flowering time, spike density, and plant height. Funct Integr Genomics (2009) 0.97
Synthesis of phycocyanobilin in mammalian cells. Chem Commun (Camb) (2013) 0.97
Do false predictions of seizures depend on the state of vigilance? A report from two seizure-prediction methods and proposed remedies. Epilepsia (2006) 0.96
EPILEPSIAE - a European epilepsy database. Comput Methods Programs Biomed (2010) 0.96