PubRank

Daniel D Billadeau

Author PubWeight™ 106.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell 2009 4.89
2 Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007 3.14
3 Retromer-mediated endosomal protein sorting: all WASHed up! Trends Cell Biol 2013 2.77
4 Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res 2005 2.72
5 VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol 2002 2.57
6 Structure and control of the actin regulatory WAVE complex. Nature 2010 2.25
7 HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 2006 2.23
8 The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol 2006 2.20
9 Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol 2003 2.15
10 Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun 2005 2.08
11 Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell 2005 2.01
12 Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol 2005 1.90
13 NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol 2006 1.78
14 WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A 2010 1.71
15 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem 2008 1.70
16 Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood 2007 1.70
17 The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 2004 1.64
18 T cell activation and the cytoskeleton: you can't have one without the other. Adv Immunol 2008 1.62
19 Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin Cancer Res 2006 1.61
20 SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol 2003 1.58
21 Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. Hepatology 2014 1.55
22 Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol 2005 1.54
23 Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell 2010 1.51
24 Targeting GSK-3: a promising approach for cancer therapy? Future Oncol 2006 1.50
25 Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol 2003 1.44
26 Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem 2004 1.40
27 Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res 2008 1.39
28 Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell 2012 1.38
29 Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell 2012 1.36
30 Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell 2013 1.32
31 Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation. Immunity 2005 1.29
32 Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J 2002 1.28
33 The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell Biol 2008 1.23
34 WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol 2007 1.21
35 Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol 2010 1.13
36 Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol 2006 1.13
37 The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol 2006 1.13
38 Epigenetic regulation of autophagy by the methyltransferase G9a. Mol Cell Biol 2013 1.10
39 Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J Biol Chem 2006 1.10
40 WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol 2012 1.10
41 The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. J Immunol 2005 1.09
42 Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading. J Immunol 2009 1.08
43 Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. PLoS One 2009 1.07
44 From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem 2009 1.06
45 IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest 2013 1.06
46 Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol 2007 1.05
47 Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol 2013 1.05
48 Rab GTPase regulation of retromer-mediated cargo export during endosome maturation. Mol Biol Cell 2012 1.05
49 Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. J Biol Chem 2004 1.04
50 A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. J Med Chem 2008 1.04
51 Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology 2011 1.04
52 Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex. J Cell Sci 2011 1.02
53 The Ezh2 methyltransferase complex: actin up in the cytosol. Trends Cell Biol 2005 1.00
54 ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility. J Biol Chem 2003 1.00
55 Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth. ChemMedChem 2008 1.00
56 PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion. J Immunol 2009 0.99
57 Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Dev Cell 2013 0.98
58 Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis. J Med Chem 2007 0.97
59 GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration. Mol Biol Cell 2011 0.95
60 Regulation of RelB expression during the initiation of dendritic cell differentiation. Mol Cell Biol 2005 0.93
61 TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation. J Immunol 2007 0.92
62 Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol 2011 0.91
63 Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J Biol Chem 2005 0.91
64 Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Infect Immun 2004 0.91
65 Differential regulation of TCR-mediated gene transcription by Vav family members. J Exp Med 2004 0.90
66 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. J Med Chem 2010 0.89
67 Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. J Biol Chem 2009 0.88
68 Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. J Biol Chem 2011 0.88
69 High cell surface death receptor expression determines type I versus type II signaling. J Biol Chem 2011 0.88
70 Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity. J Immunol 2008 0.87
71 PTEN gives neutrophils direction. Nat Immunol 2008 0.86
72 The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. J Immunol 2012 0.86
73 Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Mol Cancer Ther 2013 0.84
74 Inhibition of glycogen synthase kinase-3. Methods Mol Biol 2008 0.84
75 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. Mol Immunol 2011 0.84
76 Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II. Eur J Pharmacol 2008 0.83
77 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett 2009 0.82
78 Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes. Am J Physiol Cell Physiol 2011 0.82
79 Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression. J Biol Chem 2014 0.80
80 Response to letter by Insall. Trends Cell Biol 2013 0.75