Published in J Immunol on November 15, 2008
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A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol (2007) 3.19
USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17
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MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature (2011) 3.10
Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle (2009) 2.77
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VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol (2002) 2.57
NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol (2003) 2.33
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol (2006) 2.20
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol (2003) 2.15
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun (2005) 2.08
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol (2005) 1.90
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol (2006) 1.78
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A (2010) 1.71
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem (2008) 1.70
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem (2004) 1.64
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A (2008) 1.63
T cell activation and the cytoskeleton: you can't have one without the other. Adv Immunol (2008) 1.62
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin Cancer Res (2006) 1.61
SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol (2003) 1.58
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. Hepatology (2014) 1.55
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MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
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Targeting GSK-3: a promising approach for cancer therapy? Future Oncol (2006) 1.50
Sumoylation of MDC1 is important for proper DNA damage response. EMBO J (2012) 1.44
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol (2003) 1.44
Natural killer cell activation in mice and men: different triggers for similar weapons? Nat Immunol (2002) 1.44
ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest (2002) 1.42
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res (2008) 1.39
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol (2008) 1.38
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell (2012) 1.38
Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell (2012) 1.36
Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk. J Immunol (2007) 1.35
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32
Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol (2008) 1.32
Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation. Immunity (2005) 1.29
NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes. Semin Immunol (2006) 1.29
Human immunodeficiency virus-induced apoptosis of human hepatocytes via CXCR4. J Infect Dis (2003) 1.28
Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J (2002) 1.28
Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol Cancer Ther (2009) 1.28
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell Biol (2008) 1.23
Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. J Immunol (2004) 1.23
Regulation of SIRT1 activity by genotoxic stress. Genes Dev (2012) 1.22
WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol (2007) 1.21
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem (2012) 1.19
Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. J Immunol (2007) 1.14
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol (2010) 1.13
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol (2006) 1.13
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13
Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. Br J Haematol (2003) 1.11
WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol (2012) 1.10
Epigenetic regulation of autophagy by the methyltransferase G9a. Mol Cell Biol (2013) 1.10
Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J Biol Chem (2006) 1.10
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Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. PLoS One (2009) 1.07
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest (2013) 1.06
Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol (2007) 1.05