PubRank

James A Huntington

Author PubWeight™ 50.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature 2008 2.88
2 Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol 2004 2.26
3 Directing thrombin. Blood 2005 1.85
4 How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. Nat Struct Biol 2003 1.76
5 Crystal structure of thrombin bound to heparin. J Biol Chem 2004 1.61
6 Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. EMBO J 2006 1.59
7 Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Blood 2013 1.53
8 Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A 2002 1.46
9 NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. Proc Natl Acad Sci U S A 2010 1.38
10 Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep 2011 1.37
11 Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem 2010 1.32
12 Thrombin-cofactor interactions: structural insights into regulatory mechanisms. Arterioscler Thromb Vasc Biol 2006 1.24
13 Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem 2006 1.18
14 Crystal structure of wild-type human thrombin in the Na+-free state. Biochem J 2005 1.18
15 Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. J Biol Chem 2004 1.17
16 Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem 2010 1.14
17 A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia. Blood 2007 1.12
18 Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry 2003 1.09
19 Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states. J Biol Chem 2010 1.08
20 Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex. Proc Natl Acad Sci U S A 2009 1.07
21 Helix D elongation and allosteric activation of antithrombin. J Biol Chem 2001 1.05
22 Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J Biol Chem 2006 1.05
23 Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol. J Biol Chem 2003 1.04
24 Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol 2012 1.03
25 How small peptides block and reverse serpin polymerisation. J Mol Biol 2004 1.03
26 The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin. J Mol Biol 2009 1.02
27 Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc Natl Acad Sci U S A 2008 0.98
28 Heparin-induced substrate behavior of antithrombin Cambridge II. Blood 2003 0.94
29 Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations. J Biol Chem 2010 0.94
30 An ensemble view of thrombin allostery. Biol Chem 2012 0.94
31 Structure of native protein C inhibitor provides insight into its multiple functions. J Biol Chem 2007 0.93
32 The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism. J Biol Chem 2004 0.90
33 Allosteric activation of antithrombin critically depends upon hinge region extension. J Biol Chem 2004 0.89
34 Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis. Circulation 2004 0.88
35 The influence of hinge region residue Glu-381 on antithrombin allostery and metastability. J Biol Chem 2003 0.87
36 How serpins change their fold for better and for worse. Biochem Soc Symp 2003 0.87
37 Thrombin inhibition by serpins disrupts exosite II. J Biol Chem 2010 0.83
38 Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism. Blood 2012 0.82
39 Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments. Exp Neurol 2006 0.82
40 Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor. J Cell Biol 2007 0.82
41 Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis. FEBS J 2006 0.79
42 Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site. FEBS Lett 2006 0.79
43 The heparin binding site of protein C inhibitor is protease-dependent. J Biol Chem 2008 0.79
44 Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity. Thromb Haemost 2002 0.78
45 Targeting activated protein C to treat hemophilia. Curr Opin Hematol 2017 0.75
46 Homology model of human prothrombinase based on the crystal structure of Pseutarin C. Biol Chem 2014 0.75