Published in Nature on October 15, 2008
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Defining the mechanism of polymerization in the serpinopathies. Proc Natl Acad Sci U S A (2010) 1.48
Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. PLoS One (2010) 1.41
Structural insights into functional and pathological amyloid. J Biol Chem (2011) 1.39
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep (2011) 1.37
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pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization. Protein Sci (2010) 0.81
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. Biochem J (2015) 0.81
Local and global effects of a cavity filling mutation in a metastable serpin. Biochemistry (2009) 0.81
Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor. Nat Struct Mol Biol (2016) 0.81
Novel treatment strategies for liver disease due to α1-antitrypsin deficiency. Clin Transl Sci (2012) 0.81
Protein stability: a crystallographer's perspective. Acta Crystallogr F Struct Biol Commun (2016) 0.81
Domain-swapped dimer of Pseudomonas aeruginosa cytochrome c551: structural insights into domain swapping of cytochrome c family proteins. PLoS One (2015) 0.80
Structural biology: Serpins' mystery solved. Nature (2008) 0.80
Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure. Protein Sci (2014) 0.80
The mechanism of fibril formation of a non-inhibitory serpin ovalbumin revealed by the identification of amyloidogenic core regions. J Biol Chem (2010) 0.80
The infective polymerization of conformationally unstable antithrombin mutants may play a role in the clinical severity of antithrombin deficiency. Mol Med (2012) 0.80
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. PLoS One (2012) 0.79
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Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody. Int J Biochem Cell Biol (2014) 0.78
Therapeutic target-site variability in α1-antitrypsin characterized at high resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Domain swapping oligomerization of thermostable c-type cytochrome in E. coli cells. Sci Rep (2016) 0.78
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The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization. Biophys J (2014) 0.77
SERPINA2 is a novel gene with a divergent function from SERPINA1. PLoS One (2013) 0.77
Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization. Am J Respir Cell Mol Biol (2016) 0.76
Probing serpin conformational change using mass spectrometry and related methods. Methods Enzymol (2011) 0.76
Molecular Mechanism of Z α1-Antitrypsin Deficiency. J Biol Chem (2016) 0.76
Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization. PLoS One (2015) 0.76
Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimers. Protein Sci (2012) 0.76
IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI. Sci Rep (2016) 0.76
Stabilization, characterization, and selective removal of cystatin C amyloid oligomers. J Biol Chem (2013) 0.76
New insight into serpin polymerization and aggregation. Prion (2009) 0.76
Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle. Open Biol (2015) 0.76
Collapse of a long axis: single-molecule Förster resonance energy transfer and serpin equilibrium unfolding. Biochemistry (2014) 0.75
Small Molecule Probes That Perturb A Protein-protein Interface In Antithrombin. Chem Sci (2014) 0.75
Genome-Wide Prediction and Analysis of 3D-Domain Swapped Proteins in the Human Genome from Sequence Information. PLoS One (2016) 0.75
Structural gymnastics of multifunctional metamorphic proteins. Biophys Rev (2011) 0.75
AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor. PLoS One (2016) 0.75
Embelin binds to human neuroserpin and impairs its polymerisation. Sci Rep (2016) 0.75
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour. Biochem J (2016) 0.75
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Smoothing a rugged protein folding landscape by sequence-based redesign. Sci Rep (2016) 0.75
PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes. PLoS One (2014) 0.75
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization. FEBS J (2017) 0.75
Cirrhosis of liver: Interference of serpins in quantification of SERPINA4 - A preliminary study. Pract Lab Med (2017) 0.75
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BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics (2009) 5.67
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