PubRank

James C Whisstock

Author PubWeight™ 144.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MUSTANG: a multiple structural alignment algorithm. Proteins 2006 4.69
2 AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature 2006 3.65
3 A common fold mediates vertebrate defense and bacterial attack. Science 2007 3.43
4 A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity 2003 3.41
5 T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol 2005 2.52
6 The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 2010 2.23
7 The MACPF/CDC family of pore-forming toxins. Cell Microbiol 2008 2.15
8 An overview of the serpin superfamily. Genome Biol 2006 2.14
9 The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathog 2010 2.03
10 The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity 2009 1.98
11 A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol 2013 1.85
12 Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity 2011 1.73
13 Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res 2005 1.70
14 Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A 2009 1.63
15 The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure 2003 1.61
16 GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol 2007 1.56
17 Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood 2013 1.53
18 Computational analysis of evolution and conservation in a protein superfamily. Methods 2004 1.49
19 The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol 2006 1.48
20 Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep 2011 1.37
21 Cascleave: towards more accurate prediction of caspase substrate cleavage sites. Bioinformatics 2010 1.34
22 Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr 2008 1.33
23 Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem 2010 1.32
24 Perforin: structure, function, and role in human immunopathology. Immunol Rev 2010 1.30
25 PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PLoS One 2012 1.28
26 Automatic generation of protein structure cartoons with Pro-origami. Bioinformatics 2011 1.28
27 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell 2005 1.26
28 PoPS: a computational tool for modeling and predicting protease specificity. J Bioinform Comput Biol 2005 1.23
29 The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol 2006 1.23
30 Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol 2015 1.23
31 The X-ray crystal structure of full-length human plasminogen. Cell Rep 2012 1.22
32 Serpins in prokaryotes. Mol Biol Evol 2002 1.22
33 Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem Sci 2009 1.21
34 The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem 2005 1.21
35 Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem 2003 1.21
36 The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem 2005 1.20
37 Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem 2003 1.18
38 Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem 2002 1.17
39 Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3. Biochem Biophys Res Commun 2004 1.14
40 Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A 2009 1.14
41 COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes 2008 1.11
42 The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism. J Mol Biol 2008 1.11
43 X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A 2012 1.11
44 The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. PLoS Pathog 2010 1.10
45 Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol 2012 1.09
46 Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc Natl Acad Sci U S A 2010 1.09
47 The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria. Mol Microbiol 2011 1.07
48 Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases. Proc Natl Acad Sci U S A 2011 1.07
49 The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens. J Mol Biol 2002 1.07
50 Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol 2005 1.04
51 Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem 2006 1.03
52 Antithrombin: in control of coagulation. Int J Biochem Cell Biol 2004 1.03
53 The matrix refolded. Nat Methods 2005 1.01
54 MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography. PLoS One 2010 1.01
55 RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins. Genome Res 2007 1.01
56 Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One 2012 1.00
57 RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet 2012 1.00
58 The evolution of enzyme specificity in Fasciola spp. J Mol Evol 2003 0.99
59 Maspin (SERPINB5) is an obligate intracellular serpin. J Biol Chem 2010 0.99
60 REFOLD: an analytical database of protein refolding methods. Protein Expr Purif 2005 0.99
61 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry 2003 0.98
62 Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Infect Immun 2003 0.97
63 The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep 2007 0.97
64 The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry 2002 0.97
65 Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence. Mol Microbiol 2011 0.96
66 The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori. J Biol Chem 2013 0.96
67 Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases. Biochemistry 2002 0.96
68 Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor. Mol Immunol 2007 0.95
69 Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens. MBio 2013 0.95
70 Structural mechanisms of inactivation in scabies mite serine protease paralogues. J Mol Biol 2009 0.94
71 New insights into the structure and function of the plasminogen/plasmin system. Curr Opin Struct Biol 2013 0.94
72 Elucidation of the substrate specificity of the C1s protease of the classical complement pathway. J Biol Chem 2005 0.94
73 X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J 2006 0.94
74 Probing the role of the F-helix in serpin stability through a single tryptophan substitution. Biochemistry 2002 0.94
75 Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase. J Med Chem 2011 0.94
76 DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem 2007 0.92
77 Mechanisms of serpin dysfunction in disease. Expert Rev Mol Med 2006 0.92
78 Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol 2012 0.91
79 Predicting giant transmembrane β-barrel architecture. Bioinformatics 2012 0.90
80 The REFOLD database: a tool for the optimization of protein expression and refolding. Nucleic Acids Res 2006 0.89
81 X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin. Blood 2007 0.89
82 CLIMS: crystallography laboratory information management system. Acta Crystallogr D Biol Crystallogr 2004 0.89
83 Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets. Bioinformatics 2013 0.89
84 The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase. J Mol Biol 2006 0.88
85 Structure of granzyme C reveals an unusual mechanism of protease autoinhibition. Proc Natl Acad Sci U S A 2009 0.88
86 SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem 2007 0.88
87 The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J Biol Chem 2004 0.88
88 A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2. Mycol Res 2008 0.88
89 The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. PLoS One 2010 0.87
90 Prodepth: predict residue depth by support vector regression approach from protein sequences only. PLoS One 2009 0.87
91 A structural basis for loop C-sheet polymerization in serpins. J Mol Biol 2008 0.87
92 Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis. J Mol Biol 2006 0.87
93 S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction. J Biol Chem 2011 0.87
94 X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J Mol Biol 2012 0.87
95 SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. J Biol Chem 2007 0.87
96 Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap. J Biol Chem 2007 0.86
97 Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs. Nucleic Acids Res 2011 0.86
98 Structural determinants of GAD antigenicity. Mol Immunol 2009 0.85
99 Defining the interaction of perforin with calcium and the phospholipid membrane. Biochem J 2013 0.85
100 Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers. Biol Chem 2010 0.85
101 Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing. Proc Natl Acad Sci U S A 2013 0.85
102 The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module. J Biol Chem 2012 0.85
103 Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes. Biochemistry 2003 0.84
104 Bioinformatic approaches for predicting substrates of proteases. J Bioinform Comput Biol 2011 0.84
105 A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. J Biol Chem 2013 0.83
106 Crystallography of serpins and serpin complexes. Methods Enzymol 2011 0.83
107 Subunit gamma-green fluorescent protein fusions are functionally incorporated into mitochondrial F1F0-ATP synthase, arguing against a rigid cap structure at the top of F1. J Biol Chem 2002 0.83
108 Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A 2013 0.82
109 Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide. J Biol Chem 2002 0.81
110 The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome. J Biol Chem 2013 0.81
111 EGM: encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes. Bioinformatics 2010 0.81
112 MrGrid: a portable grid based molecular replacement pipeline. PLoS One 2010 0.81
113 Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1. Biochem J 2009 0.80
114 Structural biology: Serpins' mystery solved. Nature 2008 0.80
115 The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus. PLoS One 2012 0.80
116 Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates. Biochemistry 2003 0.80
117 Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.79
118 The perforin pore facilitates the delivery of cationic cargos. J Biol Chem 2014 0.79
119 PoPS: a computational tool for modeling and predicting protease specificity. Proc IEEE Comput Syst Bioinform Conf 2004 0.79
120 Conformational change in the chromatin remodelling protein MENT. PLoS One 2009 0.78
121 A versatile monoclonal antibody specific to human SERPINB5. Hybridoma (Larchmt) 2012 0.78
122 Serpins: finely balanced conformational traps. IUBMB Life 2002 0.77
123 Predicting serpin/protease interactions. Methods Enzymol 2011 0.77
124 Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates. Biosci Rep 2013 0.77
125 Determination of the P1', P2' and P3' subsite-specificity of factor Xa. Int J Biochem Cell Biol 2003 0.77
126 Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. Biochemistry 2003 0.77
127 The human serpin proteinase inhibitor-9 self-associates at physiological temperatures. Protein Sci 2004 0.76
128 Biology of serpins. Preface. Methods Enzymol 2011 0.75
129 Managing and mining protein crystallization data. Proteins 2006 0.75
130 Serpin structure and evolution. Preface. Methods Enzymol 2011 0.75
131 Highlight: the biology of proteolytic systems. Biol Chem 2010 0.75
132 Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. Sci Rep 2016 0.75