Published in Adv Hematol on May 19, 2010
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med (2013) 1.89
Non-transfusion-dependent thalassemias. Haematologica (2013) 1.21
β-thalassemia intermedia: a clinical perspective. Cold Spring Harb Perspect Med (2012) 1.14
The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia. Blood Rev (2012) 1.07
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica (2015) 1.06
Iron overload in Beta thalassaemia major and intermedia patients. Maedica (Buchar) (2013) 0.85
Alterations in bone and erythropoiesis in hemolytic anemia: comparative study in bled, phenylhydrazine-treated and Plasmodium-infected mice. PLoS One (2012) 0.82
Crosstalk between Erythropoiesis and Iron Metabolism. Adv Hematol (2010) 0.76
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood (2016) 0.75
Effect of iron overload on furin expression in wild-type and β-thalassemic mice. Toxicol Rep (2015) 0.75
A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med (2005) 21.48
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet (2005) 18.59
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature (2005) 18.43
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell (2005) 17.41
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem (2000) 8.52
Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem (2000) 8.39
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest (2002) 7.90
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood (2002) 7.58
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46
Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem (2005) 5.58
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell (2000) 5.31
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett (2000) 5.22
A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem (2000) 5.21
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell (1998) 4.77
Interleukin-6 induces hepcidin expression through STAT3. Blood (2006) 4.24
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Hepcidin in iron overload disorders. Blood (2005) 2.88
Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol (2005) 2.82
The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica (2006) 2.80
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood (2009) 2.65
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia (2007) 2.49
Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest (2007) 2.39
Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem (2006) 2.39
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol (2000) 2.25
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res (2006) 2.16
Vascular complications after splenectomy for hematologic disorders. Blood (2009) 1.89
The hypercoagulable state in thalassemia. Blood (2002) 1.88
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood (2008) 1.72
BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood (2007) 1.64
Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol (2004) 1.61
The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major. Blood (2000) 1.49
Ineffective erythropoiesis in beta-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage. Exp Hematol (2000) 1.43
Signal transduction in the erythropoietin receptor system. Exp Cell Res (1999) 1.40
Ineffective erythropoiesis and thalassemias. Curr Opin Hematol (2009) 1.34
EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. Blood (2007) 1.33
Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol (2006) 1.31
Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood (2008) 1.31
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25
Comparative studies of duodenal and macrophage ferroportin proteins. Am J Physiol Gastrointest Liver Physiol (2005) 1.25
Erythroblastic islands: specialized microenvironmental niches for erythropoiesis. Curr Opin Hematol (2006) 1.23
mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Am J Hematol (2006) 1.22
Chelation therapy in beta-thalassemia: an optimistic update. Semin Hematol (2001) 1.17
Pathophysiology of thalassemia. Curr Opin Hematol (2002) 1.14
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood (2009) 1.09
Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol (2008) 1.09
Functional p85alpha gene is required for normal murine fetal erythropoiesis. Blood (2003) 0.94
Asymptomatic brain magnetic resonance imaging abnormalities in splenectomized adults with thalassemia intermedia. J Thromb Haemost (2009) 0.89
Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia. Ann N Y Acad Sci (2005) 0.88
Erythropoietin receptor: cloning strategy and structural features. Int J Cell Cloning (1990) 0.88
Stroke in thalassemia: a dilemma. Am J Hematol (2008) 0.81
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med (2013) 1.89
β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood (2011) 1.81
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood (2008) 1.72
Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proc Natl Acad Sci U S A (2009) 1.64
Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol (2004) 1.61
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest (2013) 1.44
Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol (2006) 1.31
Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene. Blood (2002) 1.29
mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Am J Hematol (2006) 1.22
Non-transfusion-dependent thalassemias. Haematologica (2013) 1.21
Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood (2013) 1.15
Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia. Hematol Oncol Clin North Am (2010) 1.14
Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol (2012) 1.09
The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica (2012) 1.08
Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy. Hum Gene Ther (2007) 1.03
Role of iron in inducing oxidative stress in thalassemia: Can it be prevented by inhibition of absorption and by antioxidants? Ann N Y Acad Sci (2005) 1.03
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood (2010) 0.99
Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients. PLoS One (2012) 0.99
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A (2013) 0.98
Regulation of iron absorption in hemoglobinopathies. Curr Mol Med (2008) 0.97
Gene therapy for hemoglobinopathies: progress and challenges. Transl Res (2013) 0.96
Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models. Ann N Y Acad Sci (2010) 0.93
Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling. Blood (2012) 0.93
Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients. Am J Hematol (2009) 0.90
Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia. Ann N Y Acad Sci (2005) 0.88
Gene therapy in thalassemia and hemoglobinopathies. Mediterr J Hematol Infect Dis (2009) 0.86
A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction. Ann Hematol (2012) 0.86
Real-time multiplex analysis of four beta-thalassemia mutations employing surface plasmon resonance and biosensor technology. Lab Invest (2004) 0.86
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response. J Clin Invest (2013) 0.85
FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis. Am J Hematol (2014) 0.85
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. PLoS One (2009) 0.84
Progress toward the genetic treatment of the beta-thalassemias. Ann N Y Acad Sci (2005) 0.84
A preclinical approach for gene therapy of beta-thalassemia. Ann N Y Acad Sci (2010) 0.84
Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis. Expert Rev Hematol (2011) 0.84
Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations. Biotechnol Appl Biochem (2009) 0.84
FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis. J Biol Chem (2014) 0.83
Therapeutic globin gene delivery using lentiviral vectors. Curr Opin Mol Ther (2002) 0.83
Iron and reactive oxygen species: friends or foes of cancer cells? Antioxid Redox Signal (2013) 0.82
Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. Am J Hematol (2010) 0.81
Hepcidin and Hfe in iron overload in beta-thalassemia. Ann N Y Acad Sci (2010) 0.81
Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia. Expert Rev Hematol (2013) 0.79
Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual. Calcif Tissue Int (2010) 0.79
Globin gene transfer for treatment of the beta-thalassemias and sickle cell disease. Best Pract Res Clin Haematol (2004) 0.78
Protective role of calreticulin in HFE hemochromatosis. Free Radic Biol Med (2007) 0.78
In vivo gene transfer strategies to achieve partial correction of von Willebrand disease. Hum Gene Ther (2012) 0.75
Surface plasmon resonance and biosensor technology for real-time molecular diagnosis of beta o 39 thalassemia mutation. Mol Diagn (2004) 0.75
Quantitation of Bt-176 maize genomic sequences by surface plasmon resonance-based biospecific interaction analysis of multiplex polymerase chain reaction (PCR). J Agric Food Chem (2003) 0.75