Low vitamin D status: definition, prevalence, consequences, and correction.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMC 4315502)

Published in Endocrinol Metab Clin North Am on June 01, 2010

Authors

Neil Binkley1, Rekha Ramamurthy, Diane Krueger

Author Affiliations

1: University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA. nbinkley@wisc.edu

Associated clinical trials:

The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency (VDD) | NCT01991054

Articles citing this

Vitamin D and the anti-viral state. J Clin Virol (2011) 1.40

Misleading measures in Vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. Nutr J (2011) 1.05

Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol (2011) 1.03

The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes. Korean J Intern Med (2014) 0.94

Brazilian consensus on photoprotection. An Bras Dermatol (2015) 0.94

Regulation of calcitriol biosynthesis and activity: focus on gestational vitamin D deficiency and adverse pregnancy outcomes. Nutrients (2015) 0.90

Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study. J Transl Med (2013) 0.89

25(OH) vitamin D is associated with greater muscle strength in healthy men and women. Med Sci Sports Exerc (2013) 0.89

No relationship between vitamin D status and insulin resistance in a group of high school students. J Clin Res Pediatr Endocrinol (2011) 0.86

Hypovitaminosis D and severe hypocalcaemia: the rebirth of an old disease. BMJ Case Rep (2013) 0.80

Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease. Biomed Res Int (2015) 0.79

Serum 25(OH)D Level and Parathyroid Hormone in Chinese Adult Population: A Cross-Sectional Study in Guiyang Urban Community from Southeast of China. Int J Endocrinol (2013) 0.79

Endocrine and metabolic disorders in β-thalassemiamajor patients. Caspian J Intern Med (2012) 0.78

Vitamin D levels in patients of acute leukemia before and after remission-induction therapy. Pak J Med Sci (2013) 0.77

25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials. J Obes Weight Loss Ther (2013) 0.77

Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density). BMC Musculoskelet Disord (2011) 0.75

A randomized clinical trial comparing 3 different replacement regimens of vitamin D in clinically asymptomatic pediatrics and adolescents with vitamin D insufficiency. Ital J Pediatr (2016) 0.75

Cholecalciferol and Cancer: Is It a Big D3-eal? J Adv Pract Oncol (2012) 0.75

Vitamin D Deficiency in Children and Adolescents in Bağcılar, İstanbul. J Clin Res Pediatr Endocrinol (2015) 0.75

Vitamin D Deficiency Treatment Patterns in Academic Urban Medical Center. Am J Pharm Benefits (2014) 0.75

Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease. J Korean Med Sci (2015) 0.75

Evaluation of vitamin D level in patients from neurosurgical intensive care unit. Neural Regen Res (2013) 0.75

Articles cited by this

(truncated to the top 100)

Vitamin D deficiency. N Engl J Med (2007) 59.34

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74

Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr (2006) 10.95

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr (2007) 9.61

The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab (2007) 8.91

High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc (2006) 8.78

Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73

Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet (2005) 8.49

Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr (2002) 7.34

Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19

Estimates of optimal vitamin D status. Osteoporos Int (2005) 7.13

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med (1997) 6.88

Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med (2009) 6.84

Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev (2001) 6.77

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr (1999) 6.64

Effect of Vitamin D on falls: a meta-analysis. JAMA (2004) 6.64

Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr (2003) 6.50

Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab (2004) 6.41

Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr (2005) 6.32

Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr (2008) 6.26

Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone (2002) 6.02

Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA (2005) 5.95

Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr (2004) 5.88

Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab (2005) 5.64

Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med (2009) 5.63

Redefining vitamin D insufficiency. Lancet (1998) 5.26

The role of vitamin D in cancer prevention. Am J Public Health (2005) 4.99

Secular trends in dietary intake in the United States. Annu Rev Nutr (2004) 4.59

Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr (2003) 4.24

1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol (2001) 4.06

Nonclassic actions of vitamin D. J Clin Endocrinol Metab (2008) 3.71

Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab (2004) 3.71

Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest (1985) 3.59

Vitamin D and diabetes. Diabetologia (2005) 3.58

Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol (2005) 3.44

Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab (2007) 3.36

An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos Int (1999) 3.07

Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension (1997) 3.06

Vitamin D deficiency inhibits pancreatic secretion of insulin. Science (1980) 3.00

Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr (1995) 2.98

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.95

Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med (2007) 2.83

The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med (2006) 2.78

Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev (2004) 2.75

Vitamin D insufficiency in a population of healthy western Canadians. CMAJ (2002) 2.73

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr (1998) 2.72

25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation (2005) 2.71

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child (2008) 2.70

A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol (2003) 2.69

Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab (2007) 2.68

Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab (2007) 2.55

Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol (1990) 2.46

Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med (2008) 2.44

Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr (2002) 2.38

Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol (1991) 2.33

Sunlight, cholesterol and coronary heart disease. QJM (1996) 2.31

Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr (2004) 2.29

The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem (2003) 2.22

Vitamin D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol (2007) 2.21

Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol (2007) 2.20

Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science (1981) 2.20

The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr (2006) 2.19

Vitamin D and muscle function. Osteoporos Int (2002) 2.17

Vitamin D deficiency in older men. J Clin Endocrinol Metab (2009) 2.13

Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest (1987) 2.12

A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc (2007) 2.12

Reduced vitamin D in acute stroke. Stroke (2005) 2.07

Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int (2000) 2.02

Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res (2008) 2.00

Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J Clin Invest (1989) 1.98

Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int (2008) 1.97

Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. Am J Clin Nutr (2004) 1.79

Too little vitamin D in premenopausal women: why should we care? Am J Clin Nutr (2002) 1.79

Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int (2008) 1.78

Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab (2002) 1.76

The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J (1988) 1.76

25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr (2008) 1.73

Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study. J Clin Endocrinol Metab (1998) 1.70

Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab (2009) 1.64

Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest (2005) 1.54

Vitamin D toxicity, policy, and science. J Bone Miner Res (2007) 1.48

Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Nutr Rev (2003) 1.45

Vitamin D requirements: current and future. Am J Clin Nutr (2004) 1.37

Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study. Arch Dermatol (1988) 1.30

Altitude and arteriosclerotic heart disease mortality in white residents of 99 of the 100 largest cities in the United States. J Chronic Dis (1979) 1.27

THE INDUCTION OF GROWTH PROMOTING AND CALCIFYING PROPERTIES IN A RATION BY EXPOSURE TO LIGHT. Science (1924) 1.25

Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract (2009) 1.24

Myopathy and neuropathy associated with osteomalacia. Acta Neurol Scand (1975) 1.21

Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc (2003) 1.18

The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. 1922. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. J Biol Chem (2002) 1.16

Demonstration of 1,25(OH)2 vitamin D3 receptors and actions in vascular smooth muscle cells in vitro. Calcif Tissue Int (1987) 1.11

Misconceptions - vitamin D insufficiency causes malabsorption of calcium. Bone (2008) 1.11

Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J Clin Endocrinol Metab (1999) 1.08

Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology (2001) 1.05

Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes (2008) 1.04

Recommendations to prevent skin cancer by reducing exposure to ultraviolet radiation. Am J Prev Med (2004) 0.97

Barriers to optimizing vitamin D3 intake for the elderly. J Nutr (2006) 0.97

In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D(3). Arch Biochem Biophys (2000) 0.96

Can vitamin D reduce total mortality? Arch Intern Med (2007) 0.96

Articles by these authors

A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One (2012) 1.44

Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res (2009) 1.08

Recalculation of the NHANES database SD improves T-score agreement and reduces osteoporosis prevalence. J Bone Miner Res (2004) 1.00

Interobserver reproducibility of criteria for vertebral body exclusion. J Bone Miner Res (2004) 0.98

An overlying fat panniculus affects femur bone mass measurement. J Clin Densitom (2003) 0.96

25-hydroxyvitamin D measurement, 2009: a review for clinicians. J Clin Densitom (2009) 0.95

Tongue strength is associated with jumping mechanography performance and handgrip strength but not with classic functional tests in older adults. J Am Geriatr Soc (2013) 0.90

Jumping mechanography: a potential tool for sarcopenia evaluation in older individuals. J Clin Densitom (2010) 0.90

The Official Positions of the International Society for Clinical Densitometry: Indications of Use and Reporting of DXA for Body Composition. J Clin Densitom (2013) 0.88

Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys. J Bone Miner Res (2007) 0.84

Evaluation and correction of low vitamin D status. Curr Osteoporos Rep (2008) 0.84

What should DXA reports contain? Preferences of ordering health care providers. J Clin Densitom (2008) 0.84

Use of the lowest vertebral body T-score to diagnose lumbar osteoporosis in men: is "cherry picking" appropriate? J Clin Densitom (2004) 0.83

Densitometric diagnosis of osteoporosis in men: effect of measurement site and normative database. J Clin Densitom (2002) 0.82

Clinical observations in total body DXA: technical aspects of positioning and analysis. J Clin Densitom (2012) 0.80

Total body DXA: on the cusp of clinical care. J Clin Densitom (2012) 0.79

Addition of right lateral decubitus positioning improves vertebral visualization with VFA in selected patients. J Clin Densitom (2006) 0.78

Low vitamin D status: time to recognize and correct a Wisconsin epidemic. WMJ (2007) 0.78

Low vitamin D status: definition, prevalence, consequences, and correction. Rheum Dis Clin North Am (2012) 0.78

Osteoporosis in men. WMJ (2002) 0.78

Combination therapy for osteoporosis: considerations and controversy. Curr Osteoporos Rep (2005) 0.78

Update on osteoporosis from the 2014 Santa Fe Bone symposium. Endocr Res (2015) 0.77

Effect of female database use for T-score derivation in men. J Clin Densitom (2007) 0.76

Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence. J Cachexia Sarcopenia Muscle (2012) 0.75

Rhabdomyolysis. Nursing (2007) 0.75

DOES VITAMIN D METABOLITE MEASUREMENT HELP PREDICT 25(OH)D CHANGE FOLLOWING VITAMIN D SUPPLEMENTATION? Endocr Pract (2017) 0.75

Are Wisconsin physicians knowledgeable about male osteoporosis? WMJ (2003) 0.75

Creatine kinase: An assay with muscle. Nursing (2008) 0.75

Identifying carbon monoxide poisoning. Nursing (2004) 0.75

Is lateral spine densitometric assessment equivalent to lateral radiography? J Bone Miner Res (2002) 0.75

Slight abduction/adduction deviations in femur positioning for dual-energy X-ray absorptiometry are inconsequential. J Clin Densitom (2009) 0.75

Combination therapy for osteoporosis: considerations and controversy. Curr Rheumatol Rep (2005) 0.75

A new tool to asses risk of wandering in hospitalized patients. J Gerontol Nurs (2014) 0.75