Published in EMBO J on May 28, 2010
RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet (2015) 1.90
The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. EMBO J (2013) 1.61
The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis. PLoS Genet (2016) 1.39
Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6. Proc Natl Acad Sci U S A (2010) 1.39
Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast. J Biol Chem (2010) 1.37
Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast. EMBO J (2012) 1.31
Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes. Open Biol (2012) 1.29
Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast. Curr Opin Genet Dev (2012) 1.25
RNAi triggered by specialized machinery silences developmental genes and retrotransposons. Nature (2012) 1.24
The fission yeast RNA binding protein Mmi1 regulates meiotic genes by controlling intron specific splicing and polyadenylation coupled RNA turnover. PLoS One (2011) 1.23
Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast. EMBO J (2011) 1.22
Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Cell (2013) 1.19
Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. PLoS Genet (2012) 1.15
Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci (2011) 1.10
Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins. Mol Cell (2012) 1.07
The regulation and functions of the nuclear RNA exosome complex. Nat Rev Mol Cell Biol (2016) 1.07
Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity. Wiley Interdiscip Rev RNA (2013) 1.04
The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues. PLoS Genet (2011) 1.02
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay. PLoS Genet (2013) 1.01
Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex. RNA (2014) 1.00
Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe. Mol Syst Biol (2011) 0.99
Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing. Proc Natl Acad Sci U S A (2015) 0.99
A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts. Mol Biol Cell (2010) 0.99
The selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.96
The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Nat Struct Mol Biol (2014) 0.96
Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe. PLoS One (2012) 0.92
PABPN1: molecular function and muscle disease. FEBS J (2013) 0.92
The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Nat Commun (2015) 0.89
A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts. Nucleic Acids Res (2013) 0.89
Introns regulate gene expression in Cryptococcus neoformans in a Pab2p dependent pathway. PLoS Genet (2013) 0.87
Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast. PLoS One (2012) 0.85
Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay. Mol Cell Biol (2013) 0.85
Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast. Nucleic Acids Res (2013) 0.85
Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1. Open Biol (2014) 0.84
RNA polyadenylation sites on the genomes of microorganisms, animals, and plants. PLoS One (2013) 0.84
Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs. PLoS Genet (2015) 0.84
Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. Epigenetics Chromatin (2015) 0.83
Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1. Cell Rep (2015) 0.83
Optimisation of the Schizosaccharomyces pombe urg1 expression system. PLoS One (2013) 0.79
A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1. Nucleic Acids Res (2015) 0.79
Long noncoding RNA-based chromatin control of germ cell differentiation: a yeast perspective. Chromosome Res (2013) 0.79
mRNA quality control goes transcriptional. Biochem Soc Trans (2013) 0.79
Motif types, motif locations and base composition patterns around the RNA polyadenylation site in microorganisms, plants and animals. BMC Evol Biol (2014) 0.78
The nuclear exosome is active and important during budding yeast meiosis. PLoS One (2014) 0.78
Viral Evasion and Manipulation of Host RNA Quality Control Pathways. J Virol (2016) 0.77
A dominant role for meiosis-specific 3' RNA processing in controlling expression of a fission yeast cyclin gene. RNA (2012) 0.76
Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly. Mol Cell (2016) 0.76
Comparative analysis of the base compositions of the pre-mRNA 3' cleaved-off region and the mRNA 3' untranslated region relative to the genomic base composition in animals and plants. PLoS One (2014) 0.76
New romance between RNA degradation pathways: Mmi1 and RNAi meet on heterochromatic islands. EMBO J (2012) 0.76
An antisense RNA-mediated mechanism eliminates a meiosis-specific copper-regulated transcript in mitotic cells. J Biol Chem (2015) 0.75
Multiple Transcriptional and Post-Transcriptional Pathways Collaborate To Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast. Genetics (2016) 0.75
The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis. RNA (2016) 0.75
Relative contributions of the structural and catalytic roles of Rrp6 in exosomal degradation of individual mRNAs. RNA (2016) 0.75
The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation. RNA (2017) 0.75
The C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage. Biol Open (2013) 0.75
Ubiquitination-dependent control of sexual differentiation in fission yeast. Elife (2017) 0.75
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast (1998) 18.47
The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell (1997) 8.94
Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell (2005) 8.55
RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell (2005) 7.37
Functions of the exosome in rRNA, snoRNA and snRNA synthesis. EMBO J (1999) 5.68
A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol (2005) 5.43
A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol (2006) 4.84
Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae. Genes Dev (2004) 4.61
Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation. J Biol Chem (1998) 3.45
Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase. Nucleic Acids Res (1991) 3.18
Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids. Eur J Biochem (1970) 2.81
RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Cell (2007) 2.78
The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J (1988) 2.74
RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor. Science (1994) 2.70
Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature (2006) 2.64
S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell (1994) 2.57
A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p. Mol Cell Biol (2000) 2.56
Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis. EMBO J (1988) 2.54
The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs. Mol Cell (2010) 2.22
Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends. J Biol Chem (1996) 1.90
Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature (1997) 1.79
RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast. Cell (1998) 1.49
Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS One (2007) 1.41
U2 small nuclear RNA is remarkably conserved between Schizosaccharomyces pombe and mammals. Mol Cell Biol (1988) 1.36
Requirement of fission yeast Cid14 in polyadenylation of rRNAs. Mol Cell Biol (2006) 1.34
Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast. J Biol Chem (2007) 1.26
The fission yeast meiotic regulator Mei2p forms a dot structure in the horse-tail nucleus in association with the sme2 locus on chromosome II. Mol Biol Cell (2003) 1.19
Pac1p, an RNase III homolog, is required for formation of the 3' end of U2 snRNA in Schizosaccharomyces pombe. RNA (1999) 1.17
Quality control of bacterial mRNA decoding and decay. Biochim Biophys Acta (2008) 0.98
The Schizosaccharomyces pombe pla1 gene encodes a poly(A) polymerase and can functionally replace its Saccharomyces cerevisiae homologue. Nucleic Acids Res (1996) 0.91
Participation of XPB/Ptr8p, a component of TFIIH, in nucleocytoplasmic transport of mRNA in fission yeast. Genes Cells (2007) 0.86
Nuclear poly(a)-binding proteins and nuclear degradation: take the mRNA and run? Mol Cell (2010) 0.82
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol (2004) 8.94
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet (2003) 6.69
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med (2004) 5.88
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci U S A (2008) 5.18
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med (2005) 4.31
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal (2005) 4.20
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem (2002) 4.14
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul (2006) 3.90
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell (2012) 3.90
Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nat Cell Biol (2002) 3.85
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells (2011) 3.76
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res (2008) 3.56
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol (2006) 3.27
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J (2003) 3.13
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med (2004) 3.09
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A (2004) 2.94
MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol (2005) 2.85
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun (2005) 2.85
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol (2002) 2.82
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther (2007) 2.71
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology (2008) 2.70
Distinct cohesin complexes organize meiotic chromosome domains. Science (2003) 2.68
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem (2006) 2.66
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J (2007) 2.65
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature (2006) 2.64
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem (2006) 2.61
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol (2008) 2.57
GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol (2005) 2.55
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells (2002) 2.43
The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J (2004) 2.43
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 2.37
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J (2003) 2.28
Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci (2013) 2.26
Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosis. Science (2012) 2.26
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res (2004) 2.23
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther (2012) 2.22
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells (2005) 2.18
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol (2008) 2.15
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest (2011) 2.13
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
The transcriptional programme of antibody class switching involves the repressor Bach2. Nature (2004) 2.09
Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A (2007) 2.06
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res (2009) 2.04
The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol (2008) 2.03
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem Biophys Res Commun (2003) 2.01
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem (2002) 2.00
Essential and instructive roles of GATA factors in eosinophil development. J Exp Med (2002) 1.98
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res (2004) 1.95
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. Am J Respir Crit Care Med (2005) 1.94
Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate. Nat Chem Biol (2007) 1.93
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development (2003) 1.90
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol (2009) 1.90
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A (2004) 1.88
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol (2006) 1.86
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol (2007) 1.86
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009) 1.85
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem (2004) 1.81
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J Immunol (2005) 1.79
Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal (2010) 1.76
Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med (2005) 1.76
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem (2008) 1.73
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells (2008) 1.72
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol (2007) 1.71
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys (2005) 1.71
Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J (2003) 1.71
Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes Cells (2007) 1.67
Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol (2009) 1.67
Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells. Curr Biol (2010) 1.67
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer (2007) 1.67
The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. Mol Biol Cell (2005) 1.66
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol Cell Biol (2005) 1.66