Published in EMBO J on May 28, 2010
Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron (2010) 7.87
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat (2012) 2.17
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell (2010) 1.65
Inhibitors of the AAA+ chaperone p97. Molecules (2015) 1.61
Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. J Biol Chem (2012) 1.32
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22
Genotype-phenotype studies of VCP-associated inclusion body myopathy with Paget disease of bone and/or frontotemporal dementia. Clin Genet (2012) 1.22
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol (2014) 1.11
Structural characterization of full-length NSF and 20S particles. Nat Struct Mol Biol (2012) 1.08
Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants. J Biol Chem (2013) 0.99
The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem (2011) 0.98
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A (2012) 0.97
Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A (2015) 0.97
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve (2012) 0.96
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. J Clin Invest (2011) 0.91
Structural and functional deviations in disease-associated p97 mutants. J Struct Biol (2012) 0.90
Novel p.Ile151Val mutation in VCP in a patient of African American descent with sporadic ALS. Neurology (2011) 0.90
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A (2015) 0.89
Architecture and assembly of the archaeal Cdc48*20S proteasome. Proc Natl Acad Sci U S A (2014) 0.88
Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex. ChemMedChem (2014) 0.87
Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine. J Mol Biol (2015) 0.84
Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy. Open Biol (2014) 0.84
ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain. PLoS One (2012) 0.83
Structural mechanisms of chaperone mediated protein disaggregation. Front Mol Biosci (2014) 0.81
A Dynamic molecular basis for malfunction in disease mutants of p97/VCP. Elife (2016) 0.80
From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. J Biomed Sci (2012) 0.80
Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain. Sci Rep (2016) 0.80
Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis. FEBS J (2015) 0.80
Simulations of the p97 complex suggest novel conformational states of hydrolysis intermediates. Protein Sci (2012) 0.80
Insights into muscle degeneration from heritable inclusion body myopathies. Front Aging Neurosci (2015) 0.79
p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions. ACS Chem Biol (2016) 0.78
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J Biol Chem (2015) 0.78
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis (2013) 0.78
The final moments of misfolded proteins en route to the proteasome. DNA Cell Biol (2014) 0.78
Mutations in the Human AAA(+) Chaperone p97 and Related Diseases. Front Mol Biosci (2016) 0.78
The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly. PLoS One (2013) 0.77
An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication. Protein Sci (2015) 0.77
Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region. Biochim Biophys Acta (2014) 0.77
Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes. Front Mol Biosci (2017) 0.76
Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858). J Bacteriol (2016) 0.75
A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1. Sci Rep (2017) 0.75
Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell. BMC Evol Biol (2016) 0.75
Toward an understanding of the Cdc48/p97 ATPase. F1000Res (2017) 0.75
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
The interpretation of protein structures: estimation of static accessibility. J Mol Biol (1971) 40.24
Likelihood-enhanced fast rotation functions. Acta Crystallogr D Biol Crystallogr (2004) 23.86
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res (1999) 11.30
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet (2004) 7.84
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell (2005) 4.97
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell (2001) 3.62
Structure of the AAA ATPase p97. Mol Cell (2000) 3.37
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol (2001) 3.15
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. EMBO J (2002) 3.12
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol (2003) 2.93
The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell (2003) 2.89
Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase. J Struct Biol (2006) 2.66
UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell Mol Life Sci (2008) 2.59
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions. J Struct Biol (2004) 2.35
Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol (2005) 2.31
Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation. Hum Mol Genet (2005) 2.01
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem (2002) 1.97
Mutant valosin-containing protein causes a novel type of frontotemporal dementia. Ann Neurol (2005) 1.94
Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants. EMBO J (2002) 1.79
Pathological consequences of VCP mutations on human striated muscle. Brain (2006) 1.68
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J (2006) 1.48
Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation. Mol Cell Biol (2009) 1.47
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97. FEBS Lett (1998) 1.46
p97, a protein coping with multiple identities. J Cell Sci (2003) 1.45
Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model. J Mol Biol (2003) 1.36
Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. J Biol Chem (2008) 1.36
Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene. Neurology (2005) 1.28
Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand: a thermodynamic study of ligand binding to protein tyrosine phosphatase 1B. Anal Biochem (1998) 1.21
Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings. Neuromuscul Disord (2010) 1.20
A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia. Muscle Nerve (2009) 1.16
Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. Clin Genet (2007) 1.16
The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease. J Struct Biol (2004) 1.13
VAT, the thermoplasma homolog of mammalian p97/VCP, is an N domain-regulated protein unfoldase. J Biol Chem (2005) 1.13
The use of blue native PAGE in the evaluation of membrane protein aggregation states for crystallization. J Appl Crystallogr (2008) 1.01
Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.81
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Phase transitions in the assembly of multivalent signalling proteins. Nature (2012) 3.49
Structural basis of gating by the outer membrane transporter FecA. Science (2002) 3.40
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol (2011) 2.65
Bio-inspired polymer composite actuator and generator driven by water gradients. Science (2013) 2.38
Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem (2002) 1.97
Safety, efficacy, and modifications of the dermal bra technique for reduction mammaplasty and ptosis correction: a 10-year retrospective study. Plast Reconstr Surg (2012) 1.96
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (2009) 1.96
Inhibitors selective for mycobacterial versus human proteasomes. Nature (2009) 1.89
Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ ATPase for remodeling bacterial RNA polymerase. Structure (2010) 1.83
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol (2008) 1.75
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest (2012) 1.71
Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex. J Mol Biol (2004) 1.70
ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54. Structure (2007) 1.69
Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site. Biochemistry (2003) 1.69
Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells. Cardiovasc Res (2012) 1.65
Polymorphisms in the transforming growth factor-beta1 gene and the risk of asthma: A meta-analysis. Respirology (2010) 1.63
A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord. Biomed Microdevices (2008) 1.63
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A (2013) 1.55
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell (2005) 1.55
Inhibitor-complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides. J Biol Chem (2007) 1.49
DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biol Ther (2009) 1.42
Improved fitting of solution X-ray scattering data to macromolecular structures and structural ensembles by explicit water modeling. J Am Chem Soc (2010) 1.40
Characterization of unique small RNA populations from rice grain. PLoS One (2008) 1.31
Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli. Proc Natl Acad Sci U S A (2009) 1.31
Molecular crowding stabilizes folded RNA structure by the excluded volume effect. J Am Chem Soc (2010) 1.30
Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity. Proc Natl Acad Sci U S A (2011) 1.29
Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import. EMBO J (2007) 1.27
Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex. Proc Natl Acad Sci U S A (2006) 1.26
Improving impedance of implantable microwire multi-electrode arrays by ultrasonic electroplating of durable platinum black. Front Neuroeng (2010) 1.21
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding. FEBS Lett (2005) 1.16
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J (2010) 1.16
Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA. J Biol Chem (2002) 1.15
The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition. Biochemistry (2002) 1.15
Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol (2008) 1.14
A receptor-binding site as revealed by the crystal structure of CfaE, the colonization factor antigen I fimbrial adhesin of enterotoxigenic Escherichia coli. J Biol Chem (2007) 1.13
Rapid isolation of high-quality total RNA from taxus and ginkgo. Prep Biochem Biotechnol (2004) 1.12
ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion. Int J Oncol (2011) 1.12
Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein. J Biol Chem (2005) 1.12
Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest (2012) 1.11
High prevalence of dyslipidemia and associated risk factors among rural Chinese adults. Lipids Health Dis (2014) 1.11
Evidence for electron equilibrium between the two hemes bL in the dimeric cytochrome bc1 complex. J Biol Chem (2004) 1.10
Multistage collapse of a bacterial ribozyme observed by time-resolved small-angle X-ray scattering. J Am Chem Soc (2010) 1.10
Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J Neurosci (2010) 1.07
Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study. J Struct Biol (2010) 1.07
Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail. Proc Natl Acad Sci U S A (2011) 1.06
Total concentrations and speciation of heavy metals in municipal sludge from Changsha, Zhuzhou and Xiangtan in middle-south region of China. J Hazard Mater (2008) 1.06
MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction. PLoS One (2011) 1.06
Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2009) 1.05
Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone. J Struct Biol (2004) 1.05
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. J Neurochem (2007) 1.05
Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol (2013) 1.05
Structure of a multidrug transporter. Nat Biotechnol (2009) 1.04
Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. Protein Sci (2011) 1.04
Nucleotide-induced asymmetry within ATPase activator ring drives σ54-RNAP interaction and ATP hydrolysis. Genes Dev (2013) 1.04
X-ray scattering study of actin polymerization nuclei assembled by tandem W domains. Proc Natl Acad Sci U S A (2008) 1.03
Minireview: structural insights into early folding events using continuous-flow time-resolved small-angle X-ray scattering. Biopolymers (2011) 1.03
The use of blue native PAGE in the evaluation of membrane protein aggregation states for crystallization. J Appl Crystallogr (2008) 1.01
The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette. Biochemistry (2006) 1.01
Patatin-related phospholipase pPLAIIIβ-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis. Plant Cell (2011) 1.00
What Renders TAU Toxic. Front Neurol (2013) 1.00
Endogenous small RNAs in grain: semi-quantification and sequence homology to human and animal genes. Food Chem Toxicol (2008) 0.99
Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants. J Biol Chem (2013) 0.99
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1. Am J Hum Genet (2012) 0.99
Genetic diversity and genetic structure of an endangered species, Trillium tschonoskii. Biochem Genet (2005) 0.97
Immunosensors for detection of pesticide residues. Biosens Bioelectron (2008) 0.97
Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. J Biol Chem (2012) 0.97
Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler Thromb Vasc Biol (2013) 0.97
Characterization and genomic analysis of chromate resistant and reducing Bacillus cereus strain SJ1. BMC Microbiol (2010) 0.97
The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues. Biochemistry (2010) 0.96
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Arch Biochem Biophys (2010) 0.96
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2. Biochemistry (2010) 0.96
Structural analysis of cytochrome bc1 complexes: implications to the mechanism of function. Biochim Biophys Acta (2012) 0.95
Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study. J Mol Graph Model (2006) 0.95
Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Mol Cancer (2010) 0.95
Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. Clin Imaging (2012) 0.95
Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. J Mol Cell Cardiol (2010) 0.94
Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein β (C/EBPβ) during adipogenesis. Mol Cell Biol (2013) 0.94
Pleiotropism of the photoperiod-insensitive allele of Hd1 on heading date, plant height and yield traits in rice. PLoS One (2012) 0.93
Protein binding and disruption by Clp/Hsp100 chaperones. Structure (2004) 0.93
Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway. J Immunol (2010) 0.93
Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants. Toxicol In Vitro (2010) 0.92
Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland. World J Surg Oncol (2013) 0.92
Inter- and intra-molecular electron transfer in the cytochrome bc(1) complex. Biochim Biophys Acta (2002) 0.91
Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol (2012) 0.91
GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway. J Cell Biochem (2010) 0.91
Insulin-stimulated degradation of apolipoprotein B100: roles of class II phosphatidylinositol-3-kinase and autophagy. PLoS One (2013) 0.91
Using lymphocyte and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers. Environ Health Perspect (2007) 0.91
Hypospadias and residential proximity to pesticide applications. Pediatrics (2013) 0.91
Synthesis of Au-Fe3O4 heterostructured nanoparticles for in vivo computed tomography and magnetic resonance dual model imaging. Nanoscale (2013) 0.91
Catecholamine-Induced β2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. J Immunol (2013) 0.91