Published in Proc Natl Acad Sci U S A on January 09, 2012
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Structural and functional deviations in disease-associated p97 mutants. J Struct Biol (2012) 0.90
The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits. J Mol Biol (2015) 0.89
The p97-FAF1 protein complex reveals a common mode of p97 adaptor binding. J Biol Chem (2014) 0.87
Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens. J Immunol Res (2015) 0.85
Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine. J Mol Biol (2015) 0.84
Doa1 targets ubiquitinated substrates for mitochondria-associated degradation. J Cell Biol (2016) 0.84
Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy. Open Biol (2014) 0.84
ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain. PLoS One (2012) 0.83
Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP). J Biol Chem (2014) 0.82
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex. J Biol Chem (2013) 0.78
Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun (2014) 0.76
Emerging mechanistic insights into AAA complexes regulating proteasomal degradation. Biomolecules (2014) 0.75
Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation. PLoS One (2016) 0.75
Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. PLoS One (2015) 0.75
Toward an understanding of the Cdc48/p97 ATPase. F1000Res (2017) 0.75
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
A new generation of the IMAGIC image processing system. J Struct Biol (1996) 12.57
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature (2001) 7.59
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell (2005) 4.97
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J (2000) 4.48
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell (2000) 3.97
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol (2001) 3.67
Three-dimensional reconstruction of single particles from random and nonrandom tilt series. J Electron Microsc Tech (1988) 3.63
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell (2001) 3.62
Fourier shell correlation threshold criteria. J Struct Biol (2005) 3.43
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell (2008) 3.41
Structure of the AAA ATPase p97. Mol Cell (2000) 3.37
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol (2001) 3.15
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. EMBO J (2002) 3.12
Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway? Trends Biochem Sci (2006) 2.97
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol (2003) 2.93
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature (2007) 2.84
Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J (2002) 2.74
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell (2001) 2.65
An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF. EMBO J (1990) 2.60
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell (2006) 2.41
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36
Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol (2005) 2.31
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (2005) 1.86
A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. EMBO J (2010) 1.85
Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell (2007) 1.82
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
Insights into adaptor binding to the AAA protein p97. Biochem Soc Trans (2008) 1.66
ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity. J Biol Chem (2002) 1.66
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J (2006) 1.48
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem (2004) 1.41
p97 and close encounters of every kind: a brief review. Biochem Soc Trans (2004) 1.40
Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. J Biol Chem (2008) 1.36
Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model. J Mol Biol (2003) 1.36
Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29
Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22
Hierarchical binding of cofactors to the AAA ATPase p97. Structure (2011) 1.14
Protein dislocation from the endoplasmic reticulum--pulling out the suspect. Traffic (2002) 1.12
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells. J Cell Sci (2011) 1.11
Mutations in p97/VCP induce unfolding activity. FEBS Lett (2007) 1.02
Detailed structural insights into the p97-Npl4-Ufd1 interface. J Biol Chem (2007) 0.99
From the common molecular basis of the AAA protein to various energy-dependent and -independent activities of AAA proteins. Biochem Soc Trans (2008) 0.84
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing. Genes Cells (2009) 0.83
The TetR family of transcriptional repressors. Microbiol Mol Biol Rev (2005) 6.02
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trial. Circulation (2006) 3.99
Biological features of novel avian influenza A (H7N9) virus. Nature (2013) 3.24
Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys (2006) 2.90
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature (2007) 2.84
4D Proton treatment planning strategy for mobile lung tumors. Int J Radiat Oncol Biol Phys (2007) 2.80
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol (2004) 2.63
Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm. Phys Med Biol (2007) 2.57
Study on nanometric cutting of germanium by molecular dynamics simulation. Nanoscale Res Lett (2013) 2.48
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A (2008) 2.23
Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem (2012) 2.16
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A (2010) 2.06
VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. J Cell Biol (2002) 2.06
Structural insights into the activity of enhancer-binding proteins. Science (2005) 2.04
A novel class of potent influenza virus inhibitors: polysubstituted acylthiourea and its fused heterocycle derivatives. Bioorg Med Chem Lett (2005) 2.01
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet (2003) 1.99
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. Dev Cell (2006) 1.95
Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys (2010) 1.90
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell (2003) 1.84
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. J Cell Biol (2010) 1.83
Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions. J Cell Biol (2004) 1.74
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
Robust optimization of intensity modulated proton therapy. Med Phys (2012) 1.72
Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res (2008) 1.70
RNA polymerase and transcription elongation factor Spt4/5 complex structure. Proc Natl Acad Sci U S A (2010) 1.70
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J (2004) 1.68
The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton. Cell Host Microbe (2012) 1.66
Insights into adaptor binding to the AAA protein p97. Biochem Soc Trans (2008) 1.66
Effectiveness of noncoplanar IMRT planning using a parallelized multiresolution beam angle optimization method for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys (2005) 1.63
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancer. Int J Radiat Oncol Biol Phys (2008) 1.56
Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor. Mol Microbiol (2008) 1.56
Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials. J Mol Biol (2007) 1.55
Hadoop-GIS: A High Performance Spatial Data Warehousing System over MapReduce. Proceedings VLDB Endowment (2013) 1.55
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J Biol Chem (2003) 1.50
Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes. Int J Radiat Oncol Biol Phys (2005) 1.49
Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J (2006) 1.48
Structure of the whole cytosolic region of ATP-dependent protease FtsH. Mol Cell (2006) 1.46
The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: identifying a surface that binds sigma 54. Proc Natl Acad Sci U S A (2003) 1.45
Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS One (2011) 1.44
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem (2004) 1.41
Bacterial enhancer-binding proteins: unlocking sigma54-dependent gene transcription. Curr Opin Struct Biol (2006) 1.40
Structural basis of the nucleotide driven conformational changes in the AAA+ domain of transcription activator PspF. J Mol Biol (2006) 1.40
Organization of an activator-bound RNA polymerase holoenzyme. Mol Cell (2008) 1.39
Accelerating Pathology Image Data Cross-Comparison on CPU-GPU Hybrid Systems. Proceedings VLDB Endowment (2012) 1.39
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol (2007) 1.36
Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model. J Mol Biol (2003) 1.36
Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation. J Struct Biol (2006) 1.36
Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. J Biol Chem (2008) 1.36
Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology (2012) 1.34
The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. J Biol Chem (2012) 1.32
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A (2010) 1.30
Extramammary Paget's disease of scrotum--report of 25 cases and literature review. Urol Oncol (2008) 1.30
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS. Proc Natl Acad Sci U S A (2009) 1.30
The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. J Cell Biol (2003) 1.29
Controllable disorder engineering in oxygen-incorporated MoS2 ultrathin nanosheets for efficient hydrogen evolution. J Am Chem Soc (2013) 1.28
Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem (2006) 1.20
Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res (2010) 1.19
Influence of robust optimization in intensity-modulated proton therapy with different dose delivery techniques. Med Phys (2012) 1.19
A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatment. Int J Radiat Oncol Biol Phys (2012) 1.19
Beyond Gaussians: a study of single-spot modeling for scanning proton dose calculation. Phys Med Biol (2012) 1.18
Long-circulating liposomal contrast agents for magnetic resonance imaging. Magn Reson Med (2006) 1.17
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. J Biol Chem (2001) 1.17
Mechanisms for activating bacterial RNA polymerase. FEMS Microbiol Rev (2010) 1.17
The multidrug efflux regulator TtgV recognizes a wide range of structurally different effectors in solution and complexed with target DNA: evidence from isothermal titration calorimetry. J Biol Chem (2005) 1.16
Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl Res (2007) 1.14
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A (2012) 1.14
ATP-dependent transcriptional activation by bacterial PspF AAA+protein. J Mol Biol (2004) 1.13
Layer-specific anatomical, physiological and functional MRI of the retina. NMR Biomed (2008) 1.13
Periodic porous thermochromic VO2(M) films with enhanced visible transmittance. Chem Commun (Camb) (2013) 1.12
Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-α (TNF-α)-induced lipolysis in adipocytes. J Biol Chem (2011) 1.12
Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein. J Biol Chem (2005) 1.12
Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion. Mol Cancer Res (2008) 1.11
The HsiB1C1 (TssB-TssC) complex of the Pseudomonas aeruginosa type VI secretion system forms a bacteriophage tail sheathlike structure. J Biol Chem (2013) 1.11
miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem (2011) 1.11
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family. Biochim Biophys Acta (2011) 1.11
The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim Biophys Acta (2012) 1.11
Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. Lung Cancer (2011) 1.11
Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein. Mol Microbiol (2007) 1.11