Published in Eur J Epidemiol on May 29, 2010
The Generation R Study: design and cohort update 2010. Eur J Epidemiol (2010) 1.85
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiol Aging (2012) 0.92
Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY) (2016) 0.87
Case-control association mapping by proxy using family history of disease. Nat Genet (2017) 0.76
Next frontiers in the genetic epidemiology of Alzheimer's disease. Eur J Epidemiol (2012) 0.76
Renal Aging: Causes and Consequences. J Am Soc Nephrol (2016) 0.75
Power estimation for gene-longevity association analysis using concordant twins. Genet Res Int (2014) 0.75
Molecular and physiological manifestations and measurement of aging in humans. Aging Cell (2017) 0.75
Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16
From genotypes to genes: doubling the sample size. Biometrics (1997) 11.46
The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography (1979) 8.04
Biodemographic trajectories of longevity. Science (1998) 7.78
Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA (2003) 6.17
Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14
Genetic influence on human lifespan and longevity. Hum Genet (2006) 3.27
Clinical phenotype of families with longevity. J Am Geriatr Soc (2004) 2.03
Characteristics of Framingham offspring participants with long-lived parents. Arch Intern Med (2007) 1.91
Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene". Genet Epidemiol (2000) 1.60
Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci (2008) 1.44
Power for genetic association study of human longevity using the case-control design. Am J Epidemiol (2008) 1.28
Centenarian offspring: start healthier and stay healthier. J Am Geriatr Soc (2008) 1.26
Design and analysis in genetic studies of human ageing and longevity. Ageing Res Rev (2005) 1.06
Fatty acid profile of erythrocyte membranes as possible biomarker of longevity. Rejuvenation Res (2008) 1.03
Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev (2006) 1.01
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics (2007) 0.93
Measuring the genetic influence in modulating the human life span: gene-environment interaction and the sex-specific genetic effect. Biogerontology (2001) 0.92
Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models. Eur J Epidemiol (2004) 0.90
A novel sampling design to explore gene-longevity associations: the ECHA study. Eur J Hum Genet (2007) 0.86
Hematopoietic capacity and exceptional survival: the Leiden Longevity Study. J Am Geriatr Soc (2008) 0.81
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med (2004) 7.91
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet (2010) 3.63
Smoking habits, nicotine use, and congenital malformations. Obstet Gynecol (2006) 3.63
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genetic influence on human lifespan and longevity. Hum Genet (2006) 3.27
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet (2009) 3.09
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Predictors of mortality in 2,249 nonagenarians--the Danish 1905-Cohort Survey. J Am Geriatr Soc (2003) 2.79
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr (2009) 2.74
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Academic performance in adolescence after inguinal hernia repair in infancy: a nationwide cohort study. Anesthesiology (2011) 2.64
The Danish Twin Registry: 127 birth cohorts of twins. Twin Res (2002) 2.53
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet (2013) 2.39
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Men: good health and high mortality. Sex differences in health and aging. Aging Clin Exp Res (2008) 2.33
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med (2010) 2.25
Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Res (2003) 2.16
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr (2009) 2.14
Risk of suicide in twins: 51 year follow up study. BMJ (2003) 2.08
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians. J Am Geriatr Soc (2006) 2.02
Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Ann Epidemiol (2006) 1.97
Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne) (2012) 1.94
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance. J Med Genet (2009) 1.89
Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study. Stroke (2002) 1.86
Association between height and coronary heart disease mortality: a prospective study of 35,000 twin pairs. Am J Epidemiol (2006) 1.85
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Cancer risk in persons with oral cleft--a population-based study of 8,093 cases. Am J Epidemiol (2005) 1.82
A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol (2009) 1.81
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) (2011) 1.74
Risk of stroke associated with nonsteroidal anti-inflammatory drugs: a nested case-control study. Stroke (2003) 1.74
Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes (2005) 1.73
Social activity and healthy aging: a study of aging Danish twins. Twin Res Hum Genet (2007) 1.73
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Genetic liability in stroke: a long-term follow-up study of Danish twins. Stroke (2002) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes (2010) 1.70
Longevity studies in GenomEUtwin. Twin Res (2003) 1.66
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65
Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study. Eur J Endocrinol (2013) 1.61
Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet (2006) 1.59
Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity (Silver Spring) (2008) 1.56
Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia. PLoS One (2009) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell (2012) 1.55
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet (2009) 1.55
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2011) 1.51
The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older. Exp Aging Res (2002) 1.51
Genetic influence on prolonged gestation: a population-based Danish twin study. Am J Obstet Gynecol (2004) 1.51
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med (2012) 1.49
Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study. Thyroid (2013) 1.48
Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study. Paediatr Anaesth (2014) 1.47
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. Genet Epidemiol (2011) 1.47
Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat (2013) 1.46
Hand grip strength: a phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning. Genet Epidemiol (2002) 1.46
Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins. Anesthesiology (2016) 1.45
Increased prevalence of congenital heart defects in monozygotic and dizygotic twins. Circulation (2013) 1.45
The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell (2004) 1.42
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor. Neurology (2012) 1.41
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2010) 1.41
Improving activities of daily living in danish centenarians--but only in women: a comparative study of two birth cohorts born in 1895 and 1905. J Gerontol A Biol Sci Med Sci (2008) 1.40
Genetic influence on inflammation variables in the elderly. Arterioscler Thromb Vasc Biol (2004) 1.40
Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis. Breast Cancer Res Treat (2008) 1.40