Published in Diabetes on August 19, 2010
Genetic Predisposition to Food Cue Reactivity in Children | NCT03766191
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Childhood obesity. Circulation (2012) 2.28
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
The bigger picture of FTO: the first GWAS-identified obesity gene. Nat Rev Endocrinol (2013) 1.73
Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr (2012) 1.26
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet (2013) 1.23
Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med (2014) 1.19
Genome wide association study identifies KCNMA1 contributing to human obesity. BMC Med Genomics (2011) 1.18
Molecular basis of obesity: current status and future prospects. Curr Genomics (2011) 1.07
A genome-wide association study of body mass index across early life and childhood. Int J Epidemiol (2015) 1.04
Mendelian Randomisation Study of Childhood BMI and Early Menarche. J Obes (2011) 0.99
Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health. Nutr Diabetes (2012) 0.95
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. Am J Epidemiol (2013) 0.93
Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study. Obesity (Silver Spring) (2013) 0.90
Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes. Vitam Horm (2013) 0.90
The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction. Hum Hered (2013) 0.88
The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes (2013) 0.87
Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus. Eur J Clin Pharmacol (2012) 0.87
The genetics of childhood obesity and interaction with dietary macronutrients. Genes Nutr (2013) 0.87
Confounding by linkage disequilibrium. J Hum Genet (2013) 0.85
Genetic factors modulating the response to stimulant drugs in humans. Curr Top Behav Neurosci (2012) 0.84
Nongenetic determinants of age at menarche: a systematic review. Biomed Res Int (2014) 0.84
Modelling BMI trajectories in children for genetic association studies. PLoS One (2013) 0.84
Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study. PLoS One (2012) 0.84
Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children. J Hum Genet (2014) 0.84
Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. PLoS One (2011) 0.83
Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study. Ann Hum Genet (2013) 0.83
Pharmacotherapy for childhood obesity: present and future prospects. Int J Obes (Lond) (2012) 0.83
The obesity epidemic: from the environment to epigenetics - not simply a response to dietary manipulation in a thermoneutral environment. Front Genet (2011) 0.81
Associations of obesity genes with obesity-related outcomes in multiethnic children. Arch Med Res (2011) 0.80
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet (2011) 0.80
Association between rs9930506 polymorphism of the fat mass & obesity-associated (FTO) gene & onset of obesity in Polish adults. Indian J Med Res (2016) 0.78
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Combined effect of established BMI loci on obesity-related traits in an Algerian population sample. BMC Genet (2014) 0.78
Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study. Int J Obes (Lond) (2015) 0.78
The Genetics of Pediatric Obesity. Trends Endocrinol Metab (2015) 0.78
Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study. Nutr Metab (Lond) (2016) 0.77
Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study. BMC Public Health (2012) 0.77
Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study. BMC Med Genet (2016) 0.77
BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes (Lond) (2016) 0.75
Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study. BMC Med Genet (2015) 0.75
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology (2017) 0.75
The impact of genetic variants on BMI increase during childhood versus adulthood. Int J Obes (Lond) (2016) 0.75
An FTO Gene Variant Moderates the Association between Parental Restriction and Child BMI. PLoS One (2016) 0.75
Associations between TRPV4 genotypes and body mass index in Taiwanese subjects. Mol Genet Genomics (2015) 0.75
Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ (2000) 56.80
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
The spread of obesity in a large social network over 32 years. N Engl J Med (2007) 34.75
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med (1997) 19.30
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
General and abdominal adiposity and risk of death in Europe. N Engl J Med (2008) 14.49
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Genetic and environmental factors in relative body weight and human adiposity. Behav Genet (1997) 12.07
The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics (1999) 11.20
Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med (1992) 10.44
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med (2007) 8.84
Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med (2010) 8.70
Do obese children become obese adults? A review of the literature. Prev Med (1993) 7.30
Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics (2001) 6.06
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr (2008) 4.79
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes (2007) 4.19
A twin study of human obesity. JAMA (1986) 3.92
Physical activity assessed by activity monitor and doubly labeled water in children. Med Sci Sports Exerc (2001) 3.87
Use of accelerometers in a large field-based study of children: protocols, design issues, and effects on precision. J Phys Act Health (2008) 3.81
Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study). Am J Clin Nutr (2004) 3.66
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet (2009) 3.18
Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med (2008) 3.15
Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people). BMC Public Health (2008) 3.09
Relation of circumferences and skinfold thicknesses to lipid and insulin concentrations in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr (1999) 2.91
Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet (2001) 2.88
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr (2009) 2.74
The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med (2007) 2.34
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34
Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet (2009) 2.22
Objectively measured physical activity of USA adults by sex, age, and racial/ethnic groups: a cross-sectional study. Int J Behav Nutr Phys Act (2009) 2.00
Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr (2009) 1.88
Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring) (2008) 1.77
The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond) (2009) 1.71
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Distribution and heritability of BMI in Finnish adolescents aged 16y and 17y: a study of 4884 twins and 2509 singletons. Int J Obes Relat Metab Disord (1999) 1.52
Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes (Lond) (2008) 1.51
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet (2010) 1.38
Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins. Int J Obes (Lond) (2009) 1.07
Relationships of self-reported physical activity domains with accelerometry recordings in French adults. Eur J Epidemiol (2009) 1.07
Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study. Am J Clin Nutr (2009) 1.01
Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth. J Pediatr (2010) 0.90
International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc (2003) 47.83
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet (2012) 12.05
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study). Lancet (2006) 8.95
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Correlates of physical activity: why are some people physically active and others not? Lancet (2012) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. Lancet (2012) 6.81
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Physical activity levels and patterns of 9- and 15-yr-old European children. Med Sci Sports Exerc (2004) 4.67
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr (2006) 4.24
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes (2008) 4.11
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
A causal modelling approach to the development of theory-based behaviour change programmes for trial evaluation. Health Educ Res (2005) 4.06
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
TV viewing and physical activity are independently associated with metabolic risk in children: the European Youth Heart Study. PLoS Med (2006) 3.87