PubRank

Edward N Baker

Author PubWeight™ 108.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science 2007 4.10
2 The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A 2009 1.79
3 Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. J Biol Chem 2004 1.74
4 A flexible and economical medium-throughput strategy for protein production and crystallization. Acta Crystallogr D Biol Crystallogr 2005 1.67
5 The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance. J Mol Biol 2003 1.65
6 Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes. J Biol Chem 2009 1.45
7 Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis. Proc Natl Acad Sci U S A 2004 1.44
8 Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci U S A 2003 1.44
9 Intramolecular isopeptide bonds: protein crosslinks built for stress? Trends Biochem Sci 2010 1.31
10 The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord 2002 1.28
11 The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome. J Biol Chem 2002 1.28
12 The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. J Bacteriol 2009 1.27
13 Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism. Proc Natl Acad Sci U S A 2006 1.27
14 Structure and assembly of Gram-positive bacterial pili: unique covalent polymers. Curr Opin Struct Biol 2012 1.21
15 Aminoglycoside antibiotic resistance by enzymatic deactivation. Curr Drug Targets Infect Disord 2002 1.17
16 Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. J Biol Chem 2010 1.16
17 A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis. Protein Expr Purif 2007 1.14
18 Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure 2005 1.13
19 Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding. J Biol Chem 2008 1.12
20 Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. J Mol Biol 2005 1.11
21 The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J Bacteriol 2006 1.11
22 Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system. Protein Expr Purif 2007 1.10
23 The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis. J Biol Chem 2005 1.08
24 The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition. Mol Microbiol 2007 1.07
25 Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon. Proteins 2008 1.07
26 The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol 2005 1.04
27 Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 2004 1.04
28 Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J Mol Biol 2004 1.04
29 The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) 2011 1.03
30 Lactoferrin and iron: structural and dynamic aspects of binding and release. Biometals 2004 1.03
31 Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. J Bacteriol 2010 1.03
32 Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J Mol Biol 2007 1.02
33 Crystal structure of Epiphyas postvittana takeout 1 with bound ubiquinone supports a role as ligand carriers for takeout proteins in insects. J Biol Chem 2008 1.02
34 Metabolic engineering of cofactor F420 production in Mycobacterium smegmatis. PLoS One 2010 1.01
35 Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Biol Chem 2010 1.00
36 Citations in supplementary material. Acta Crystallogr D Biol Crystallogr 2010 1.00
37 Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr 2009 0.99
38 Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A 2013 0.98
39 Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS One 2011 0.98
40 Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol Microbiol 2014 0.95
41 The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor. J Bacteriol 2009 0.95
42 Isopeptide bonds in bacterial pili and their characterization by X-ray crystallography and mass spectrometry. Biopolymers 2009 0.95
43 Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. J Biol Chem 2013 0.95
44 Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. PLoS One 2011 0.93
45 Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Mol Biol 2012 0.92
46 Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry 2009 0.92
47 Defining the potassium binding region in an apple terpene synthase. J Biol Chem 2009 0.92
48 Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol 2003 0.91
49 Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr D Biol Crystallogr 2005 0.91
50 A structural perspective on lactoferrin function. Biochem Cell Biol 2012 0.91
51 Histidine phosphorylation in biological systems. Biochim Biophys Acta 2007 0.91
52 High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon. Biochemistry 2007 0.91
53 Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP. Acta Crystallogr D Biol Crystallogr 2008 0.89
54 The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses. J Virol 2007 0.89
55 Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. J Bacteriol 2010 0.89
56 Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. J Bacteriol 2006 0.88
57 Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem 2010 0.88
58 The potential impact of structural genomics on tuberculosis drug discovery. Drug Discov Today 2006 0.87
59 In defence of our science - validation now! Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.86
60 Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. J Biol Chem 2012 0.86
61 Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis. Biochemistry 2009 0.85
62 Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J Mol Biol 2009 0.85
63 The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module. J Biol Chem 2012 0.85
64 Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.85
65 Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis. Acta Crystallogr D Biol Crystallogr 2010 0.84
66 Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem 2007 0.84
67 Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin. Biochemistry 2003 0.84
68 Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2004 0.84
69 Crystallization and preliminary X-ray analysis of a conserved hypothetical protein PAE2754 from Pyrobaculum aerophilum and of a double Leu-->Met mutant engineered for MAD phasing. Acta Crystallogr D Biol Crystallogr 2004 0.84
70 Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Org Biomol Chem 2012 0.84
71 Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS One 2012 0.84
72 The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis. J Mol Biol 2008 0.83
73 Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.82
74 Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry 2012 0.82
75 Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr 2004 0.82
76 Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.82
77 Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL). Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.81
78 Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design. J Biol Chem 2011 0.81
79 The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate. J Mol Biol 2005 0.81
80 Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Acta Crystallogr D Biol Crystallogr 2006 0.81
81 Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J 2007 0.80
82 Crystallization and preliminary diffraction studies of the C-terminal domain of the DipZ homologue from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.80
83 Structural and functional properties of staphylococcal superantigen-like protein 4. Infect Immun 2012 0.80
84 Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies. Protein Sci 2014 0.80
85 The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry 2013 0.79
86 Purification, crystallization and preliminary crystallographic analysis of the minor pilin FctB from Streptococcus pyogenes. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.79
87 An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. J Struct Biol 2013 0.79
88 Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2''-phosphotransferase-Ib [APH(2'')-Ib]. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.79
89 Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. Chembiochem 2014 0.78
90 Expectation bias and information content. Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 0.78
91 Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.78
92 "Dilysine trigger" in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin. Biochemistry 2002 0.78
93 Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Org Biomol Chem 2013 0.78
94 Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding. Biochemistry 2012 0.78
95 Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg Med Chem Lett 2008 0.78
96 Cloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.78
97 Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 0.78
98 Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form. Acta Crystallogr D Biol Crystallogr 2002 0.78
99 Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization. J Biol Chem 2004 0.77
100 The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases. J Biol Chem 2006 0.77
101 Crystal structures of E. coli native MenH and two active site mutants. PLoS One 2013 0.77
102 Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin. Acta Crystallogr D Biol Crystallogr 2007 0.77
103 Purification, crystallization and preliminary crystallographic analysis of Streptococcus pyogenes laminin-binding protein Lbp. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.76
104 Ligand promiscuity within the internal cavity of Epiphyas postvittana Takeout 1 protein. J Struct Biol 2013 0.76
105 Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr 2012 0.76
106 A non-synonymous nucleotide substitution can account for one evolutionary route to sesquiterpene synthase activity in the TPS-b subgroup. FEBS Lett 2011 0.76
107 Purification, crystallization and preliminary crystallographic analysis of the adhesion domain of Epf from Streptococcus pyogenes. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 0.76
108 Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.76
109 Citations in supplementary material. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.75
110 Crystallization of a protein using dehydration without a precipitant. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.75
111 Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 0.75
112 Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. J Biol Chem 2011 0.75
113 Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Acta Crystallogr D Biol Crystallogr 2003 0.75
114 Nobel Prize for Chemistry 2012: GPCRs seen through a crystal ball. Acta Crystallogr D Biol Crystallogr 2012 0.75
115 Crystallization and preliminary X-ray analysis of N-acetyl-1-D-myo-inosityl-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr 2003 0.75
116 Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem 2015 0.75
117 Using structural genomics to understand Mycobacterium tuberculosis. IUBMB Life 2004 0.75
118 Black sheep among the flock of protein structures. Acta Crystallogr D Biol Crystallogr 2009 0.75
119 Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing. Acta Crystallogr D Biol Crystallogr 2003 0.75
120 Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis. J Pept Sci 2014 0.75
121 Expectation bias and information content. Acta Crystallogr D Biol Crystallogr 2013 0.75
122 Electron transfer between cytochrome b(5) and some oxidised haemoglobins: the role of ionic strength. J Inorg Biochem 2002 0.75
123 Small angle scattering - moving forward. Acta Crystallogr D Biol Crystallogr 2012 0.75
124 Metal-containing proteins, macrocycles, and coordination complexes in therapeutic applications and disease. Met Based Drugs 2008 0.75
125 A modeling study of the interaction and electron transfer between cytochrome b5 and some oxidized haemoglobins. J Biol Inorg Chem 2001 0.75