Repression of protein synthesis by miRNAs: how many mechanisms?

miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A (2008) 9.86

miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci U S A (2007) 7.93

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods (2008) 6.22

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69

Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35

MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A (2008) 4.33

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30

microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J (2008) 4.24

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89

Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol (2009) 3.70

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res (2009) 3.57

Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A (2011) 3.37

Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res (2008) 3.18

MicroRNA: implications for cancer. Virchows Arch (2007) 3.17

p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08

Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol (2008) 2.95

Epigenetics and environmental chemicals. Curr Opin Pediatr (2009) 2.83

The Argonaute protein family. Genome Biol (2008) 2.83

MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80

Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74

Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Res (2007) 2.74

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59

Experimental validation of miRNA targets. Methods (2008) 2.57

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol (2009) 2.54

A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci (2007) 2.54

Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene (2009) 2.49

The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1. Proc Natl Acad Sci U S A (2008) 2.40

The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci (2009) 2.35

MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33

Biochemical evidence for translational repression by Arabidopsis microRNAs. Plant Cell (2009) 2.27

MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition. J Am Soc Nephrol (2012) 2.26

MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol (2011) 2.25

miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21

Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol (2009) 2.20

Post-transcriptional gene regulation: from genome-wide studies to principles. Cell Mol Life Sci (2008) 2.18

A multifunctional human Argonaute2-specific monoclonal antibody. RNA (2008) 2.17

miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs. Plant Mol Biol (2012) 2.14

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol (2008) 1.98

Disruption of microRNA expression in human airway cells by diesel exhaust particles is linked to tumorigenesis-associated pathways. Environ Health Perspect (2009) 1.98

Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production. J Cell Biol (2008) 1.98

System wide analyses have underestimated protein abundances and the importance of transcription in mammals. PeerJ (2014) 1.93

MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab (2010) 1.92

Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92

microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle (2010) 1.90

The role of the miR-200 family in epithelial-mesenchymal transition. Cancer Biol Ther (2010) 1.89

The GAIT system: a gatekeeper of inflammatory gene expression. Trends Biochem Sci (2009) 1.88

Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology (2008) 1.87

The role of incoherent microRNA-mediated feedforward loops in noise buffering. PLoS Comput Biol (2011) 1.84

GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83

miRNA control of tumor cell invasion and metastasis. Int J Cancer (2010) 1.79

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA (2007) 1.77

Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75

MicroRNA in the immune system, microRNA as an immune system. Immunology (2009) 1.75

miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Mol Cell Biol (2009) 1.70

Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med (Berl) (2008) 1.68

Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection. RNA (2010) 1.66

MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS One (2011) 1.61

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus. PLoS One (2011) 1.60

3' Terminal oligo U-tract-mediated stimulation of decapping. RNA (2007) 1.59

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics (2014) 1.54

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int (2010) 1.54

Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53

miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget (2010) 1.53

Cellular versus viral microRNAs in host-virus interaction. Nucleic Acids Res (2008) 1.50

microRNAs and cholesterol metabolism. Trends Endocrinol Metab (2010) 1.49

A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci (2010) 1.47

Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res (2011) 1.47

A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk. Circ Cardiovasc Genet (2011) 1.47

An insect virus-encoded microRNA regulates viral replication. J Virol (2008) 1.47

Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. Am J Physiol Endocrinol Metab (2008) 1.45

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma. Oncotarget (2014) 1.44

West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells. Nucleic Acids Res (2011) 1.44

MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One (2009) 1.44

Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiol Genomics (2010) 1.43

A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43

MicroRNA: An emerging therapeutic target and intervention tool. Int J Mol Sci (2008) 1.41

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids. Nucleic Acids Res (2010) 1.41

Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer (2013) 1.40

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord (2009) 1.40

Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology (2008) 1.40

MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett (2009) 1.40

Tumor suppressor p53 meets microRNAs. J Mol Cell Biol (2011) 1.39

miRNA regulation of cytokine genes. Cytokine (2009) 1.39

Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37

MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci (2010) 1.37

mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer. Genome Biol (2009) 1.34

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathog (2011) 1.33

MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem (2012) 1.33

Small regulatory RNAs may sharpen spatial expression patterns. PLoS Comput Biol (2007) 1.32

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr (2011) 1.30

GW body disassembly triggered by siRNAs independently of their silencing activity. Nucleic Acids Res (2007) 1.29

Molecular mechanisms of chemoresistance in osteosarcoma (Review). Oncol Lett (2014) 1.29

Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors. Nat Rev Urol (2010) 1.28

Consensus miRNA expression profiles derived from interplatform normalization of microarray data. RNA (2009) 1.27

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87

Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science (2005) 13.84

Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73

Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem (2010) 12.06

Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A (2008) 8.56

Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J (2002) 6.65

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep (2005) 5.82

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr Opin Cell Biol (2009) 4.56

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA (2004) 4.50

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol (2008) 3.98

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med (2009) 3.72

Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep (2004) 3.07

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells. Nucleic Acids Res (2006) 2.96

The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol (2011) 2.70

Role of Dicer in posttranscriptional RNA silencing. Curr Top Microbiol Immunol (2008) 2.19

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA (2009) 1.80

Leishmania donovani targets Dicer1 to downregulate miR-122, lower serum cholesterol, and facilitate murine liver infection. Cell Host Microbe (2013) 1.77

A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Res (2007) 1.68

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res (2012) 1.58

ADP-ribose-1"-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture. J Virol (2005) 1.54

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep (2012) 1.52

Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J Neurosci (2008) 1.43

Molecular biology: the expanding world of small RNAs. Nature (2008) 1.35

Lack of homologous sequence-specific DNA methylation in response to stable dsRNA expression in mouse oocytes. Nucleic Acids Res (2004) 1.34

Dicer is associated with ribosomal DNA chromatin in mammalian cells. PLoS One (2010) 1.14

The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal. RNA (2013) 1.11

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression. Nucleic Acids Res (2010) 1.06

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res (2012) 1.06

Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression. Adv Exp Med Biol (2010) 1.05

Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression. Adv Exp Med Biol (2011) 1.05

Proteomics joins the search for microRNA targets. Cell (2008) 1.02

How to control miRNA maturation? RNA Biol (2009) 1.01

A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep (2013) 1.01

UBA1 and UBA2, two proteins that interact with UBP1, a multifunctional effector of pre-mRNA maturation in plants. Mol Cell Biol (2002) 0.99

Argonautes and company: sailing against the wind. Cell (2007) 0.98

dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells. Nucleic Acids Res (2011) 0.97

TRIM-NHL proteins take on miRNA regulation. Cell (2009) 0.97

ATP modulates siRNA interactions with an endogenous human Dicer complex. RNA (2005) 0.95

Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J Biol Chem (2001) 0.93

Human dicer: purification, properties, and interaction with PAZ PIWI domain proteins. Methods Enzymol (2005) 0.91

From RNAi to epigenomes: how RNA rules the world. Chembiochem (2005) 0.89

KSRP Promotes the Maturation of a Group of miRNA Precuresors. Adv Exp Med Biol (2011) 0.82

ADP-ribose-1"-phosphatase activities of the human coronavirus 229E and SARS coronavirus X domains. Adv Exp Med Biol (2006) 0.81

KSRP promotes the maturation of a group of miRNA precursors. Adv Exp Med Biol (2010) 0.80

Biophysical characterization of cyclic nucleotide phosphodiesterases. Biochem Biophys Res Commun (2002) 0.80

Retrospective. Aaron Shatkin (1934-2012). Science (2012) 0.75

Twenty-second annual Pezcoller Symposium: RNA biology and cancer. Cancer Res (2010) 0.75