Published in Environ Mol Mutagen on June 01, 2010
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev (2013) 2.02
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations. Cell Mol Life Sci (2010) 1.58
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2011) 1.57
Mitochondria as a target of environmental toxicants. Toxicol Sci (2013) 1.24
Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood (2013) 1.18
After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17
Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction. DNA Repair (Amst) (2012) 1.12
Importance of glycolysis and oxidative phosphorylation in advanced melanoma. Mol Cancer (2012) 1.10
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free Radic Biol Med (2013) 1.05
Consensus pathways implicated in prognosis of colorectal cancer identified through systematic enrichment analysis of gene expression profiling studies. PLoS One (2011) 1.04
Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies. J Toxicol (2011) 0.99
Mitochondrial respiration--an important therapeutic target in melanoma. PLoS One (2012) 0.95
β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease. Front Pharmacol (2015) 0.94
Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. PLoS One (2011) 0.94
Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells. Am J Physiol Renal Physiol (2013) 0.90
Enriched environment inhibits mouse pancreatic cancer growth and down-regulates the expression of mitochondria-related genes in cancer cells. Sci Rep (2015) 0.89
The mitochondrial genome is a "genetic sanctuary" during the oncogenic process. PLoS One (2011) 0.89
OGDHL is a modifier of AKT-dependent signaling and NF-κB function. PLoS One (2012) 0.87
Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 cells. Oxid Med Cell Longev (2013) 0.85
Modeling mitochondrial dysfunctions in the brain: from mice to men. J Inherit Metab Dis (2011) 0.84
Pathologic effects of RNase-L dysregulation in immunity and proliferative control. Front Biosci (Schol Ed) (2012) 0.83
The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. Hum Genet (2013) 0.83
From pathways to targets: understanding the mechanisms behind polyglutamine disease. Biomed Res Int (2014) 0.81
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma. Neuro Oncol (2013) 0.81
Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study. PLoS One (2014) 0.81
Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies. BioData Min (2014) 0.80
The presence of multiple cellular defects associated with a novel G50E iron-sulfur cluster scaffold protein (ISCU) mutation leads to development of mitochondrial myopathy. J Biol Chem (2014) 0.80
DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells. Free Radic Biol Med (2014) 0.80
Metabolic profile analysis of zebrafish embryos. J Vis Exp (2013) 0.80
Pharmacological properties of protocatechuic Acid and its potential roles as complementary medicine. Evid Based Complement Alternat Med (2015) 0.79
Mechanisms of action of brain insulin against neurodegenerative diseases. J Neural Transm (Vienna) (2014) 0.79
A role for human mitochondrial complex II in the production of reactive oxygen species in human skin. Redox Biol (2014) 0.79
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener (2012) 0.79
Contribution of yeast models to neurodegeneration research. J Biomed Biotechnol (2012) 0.78
Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles. Int J Cancer (2012) 0.78
How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation. Philos Trans R Soc Lond B Biol Sci (2014) 0.78
The role of mitochondria in the development and progression of lung cancer. Comput Struct Biotechnol J (2013) 0.78
The DNA repair enzyme apurinic/apyrimidinic endonuclease (Apex nuclease) 2 has the potential to protect against down-regulation of chondrocyte activity in osteoarthritis. Int J Mol Sci (2014) 0.77
Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19. J Biol Chem (2015) 0.77
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle. Nutr Metab (Lond) (2014) 0.77
Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNK/Nrf2 Survival Signals in Macrophages. Oxid Med Cell Longev (2015) 0.76
Base excision repair activities differ in human lung cancer cells and corresponding normal controls. Anticancer Res (2010) 0.75
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis. Mol Cell Biochem (2013) 0.75
Parkinson Disease and Malignant Disease: Minding Cancer's Own Business. JAMA Oncol (2015) 0.75
Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development. Mar Drugs (2015) 0.75
Role of mtDNA haplogroups in the prevalence of osteoarthritis in different geographic populations: a meta-analysis. PLoS One (2014) 0.75
In vitro Antioxidant and Enzymatic Approaches to Evaluate Neuroprotector Potential of Blechnum Extracts without Cytotoxicity to Human Stem Cells. Pharmacogn Mag (2016) 0.75
DNA repair after oxidative stress: current challenges. Curr Opin Toxicol (2017) 0.75
Mitochondrial DNA Integrity is Maintained by APE1 in Carcinogen-induced Colorectal Cancer. Mol Cancer Res (2017) 0.75
Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods (2005) 6.23
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol (2006) 2.87
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol (2004) 2.65
Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One (2011) 2.64
Prokaryotic nucleotide excision repair: the UvrABC system. Chem Rev (2006) 2.37
Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients. Mol Cell (2003) 2.12
Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol (2004) 1.90
High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab (2011) 1.89
Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta (2013) 1.85
Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol (2008) 1.81
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Role of mitochondria in toxic oxidative stress. Mol Interv (2005) 1.76
Alterations in bioenergetics due to changes in mitochondrial DNA copy number. Methods (2010) 1.62
NIEHS extramural global environmental health portfolio: opportunities for collaboration. Environ Health Perspect (2008) 1.61
Mitochondrial DNA repair and aging. Mutat Res (2002) 1.60
Structural basis for DNA recognition and processing by UvrB. Nat Struct Mol Biol (2006) 1.51
Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J Biol Chem (2002) 1.49
Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLoS One (2011) 1.48
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem (2010) 1.46
The beta -hairpin motif of UvrB is essential for DNA binding, damage processing, and UvrC-mediated incisions. J Biol Chem (2001) 1.46
Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome Biol (2007) 1.41
Collaborative dynamic DNA scanning by nucleotide excision repair proteins investigated by single- molecule imaging of quantum-dot-labeled proteins. Mol Cell (2010) 1.40
Metabolic symbiosis in cancer: refocusing the Warburg lens. Mol Carcinog (2012) 1.40
Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol Biol (2002) 1.40
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell (2004) 1.37
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet (2006) 1.32
Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology. PLoS Genet (2010) 1.32
Structural insights into the first incision reaction during nucleotide excision repair. EMBO J (2005) 1.30
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci (2012) 1.30
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem (2009) 1.29
Conceptual model of comprehensive research metrics for improved human health and environment. Environ Health Perspect (2008) 1.29
Reduction in frataxin causes progressive accumulation of mitochondrial damage. Hum Mol Genet (2003) 1.24
Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link. Biochemistry (2009) 1.23
Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc Natl Acad Sci U S A (2002) 1.20
UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity. J Biol Chem (2006) 1.20
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease. Biochemistry (2005) 1.19
Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. Am J Physiol Lung Cell Mol Physiol (2003) 1.18
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. J Biol Chem (2011) 1.18
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. Cancer Res (2012) 1.17
Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet (2005) 1.16
Prokaryotic nucleotide excision repair. Cold Spring Harb Perspect Biol (2013) 1.16
Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro. DNA Repair (Amst) (2011) 1.15
Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair. EMBO J (2004) 1.15
Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. Methods Mol Biol (2012) 1.13
Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction. DNA Repair (Amst) (2012) 1.12
Importance of glycolysis and oxidative phosphorylation in advanced melanoma. Mol Cancer (2012) 1.10
The C-terminal zinc finger of UvrA does not bind DNA directly but regulates damage-specific DNA binding. J Biol Chem (2006) 1.10
Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PLoS One (2012) 1.09
Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. EMBO J (2007) 1.09
Functional characterization and atomic force microscopy of a DNA repair protein conjugated to a quantum dot. Nano Lett (2008) 1.09
Toward the assessment of scientific and public health impacts of the National Institute of Environmental Health Sciences Extramural Asthma Research Program using available data. Environ Health Perspect (2009) 1.08
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins. Biochemistry (2007) 1.08
Analyzing the handoff of DNA from UvrA to UvrB utilizing DNA-protein photoaffinity labeling. J Biol Chem (2004) 1.07
Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress. Nucleic Acids Res (2005) 1.06
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol Dis (2011) 1.06
Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03
DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair. Biochemistry (2008) 1.03
An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress. Aging Cell (2012) 1.02
Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic Acids Res (2013) 1.02
Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. J Proteome Res (2012) 1.01
3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells. Brain Res Mol Brain Res (2005) 1.01
Structural and functional characterization of the human DNA repair helicase XPD by comparative molecular modeling and site-directed mutagenesis of the bacterial repair protein UvrB. J Biol Chem (2002) 0.99
Removal of misincorporated ribonucleotides from prokaryotic genomes: an unexpected role for nucleotide excision repair. PLoS Genet (2013) 0.98
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks. Biochemistry (2010) 0.97
Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid. Arch Biochem Biophys (2004) 0.96
NMR analysis of [methyl-13C]methionine UvrB from Bacillus caldotenax reveals UvrB-domain 4 heterodimer formation in solution. J Mol Biol (2007) 0.95
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Mol Cell Biol (2008) 0.95
Mitochondrial respiration--an important therapeutic target in melanoma. PLoS One (2012) 0.95
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol (2014) 0.95
Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget (2014) 0.94
The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination. Nucleic Acids Res (2013) 0.94
Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases. Am J Physiol Lung Cell Mol Physiol (2003) 0.94
Dynamics of lesion processing by bacterial nucleotide excision repair proteins. Prog Mol Biol Transl Sci (2012) 0.93
Identification of residues within UvrB that are important for efficient DNA binding and damage processing. J Biol Chem (2004) 0.92
Cooperative damage recognition by UvrA and UvrB: identification of UvrA residues that mediate DNA binding. DNA Repair (Amst) (2008) 0.91
A general path for large-scale solubilization of cellular proteins: from membrane receptors to multiprotein complexes. Protein Expr Purif (2012) 0.91
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Res (2011) 0.90
Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts. PLoS One (2010) 0.90
Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair. Proc Natl Acad Sci U S A (2012) 0.90
The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target? Expert Opin Ther Targets (2013) 0.90
DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway. Proc Natl Acad Sci U S A (2009) 0.89
Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes. Nucleic Acids Res (2013) 0.88
Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB. Biochemistry (2009) 0.88
Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease. Nucleic Acids Res (2008) 0.88
Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair. J Am Chem Soc (2013) 0.87
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines. Biochemistry (2002) 0.86
Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase. Free Radic Biol Med (2003) 0.86
Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. Am J Physiol Lung Cell Mol Physiol (2012) 0.86
SnapShot: Mitochondrial quality control. Cell (2011) 0.86
Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates. Proc Natl Acad Sci U S A (2014) 0.85
DNA damage in normally and prematurely aged mice. Aging Cell (2013) 0.85
Supercoiled DNA promotes formation of intercalated cis-N2-deoxyguanine adducts and base-stacked trans-N2-deoxyguanine adducts by (+)-7R,8S-dihydrodiol-9S,10R-epoxy-7,8,9,10-tetra- hydrobenzo[a]pyrene. Chem Res Toxicol (2004) 0.84
Robust incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA adducts by a recombinant thermoresistant interspecies combination UvrABC endonuclease system. Biochemistry (2006) 0.84
DNA repair gets physical: mapping an XPA-binding site on ERCC1. DNA Repair (Amst) (2008) 0.83
Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. Biochemistry (2011) 0.83
Bioenergetic analysis of intact mammalian cells using the Seahorse XF24 Extracellular Flux analyzer and a luciferase ATP assay. Methods Mol Biol (2014) 0.82
XPB helicase regulates DNA incision by the Thermoplasma acidophilum endonuclease Bax1. DNA Repair (Amst) (2012) 0.82
Integrated proteomic and metabolic analysis of breast cancer progression. PLoS One (2013) 0.81
Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol Appl Pharmacol (2005) 0.81
Reduced sulfhydryls maintain specific incision of BPDE-DNA adducts by recombinant thermoresistant Bacillus caldotenax UvrABC endonuclease. Protein Expr Purif (2003) 0.80