Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 3861539)

Published in PLoS Pathog on December 12, 2013

Authors

Ya-Ping Ko1, Annemarie Kuipers2, Claudia M Freitag3, Ilse Jongerius4, Eva Medina5, Willemien J van Rooijen2, András N Spaan2, Kok P M van Kessel2, Magnus Höök1, Suzan H M Rooijakkers2

Author Affiliations

1: Center for Infectious and Inflammatory Disease, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America.
2: Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
3: Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands ; Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht, The Netherlands.
4: Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands ; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
5: Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Articles citing this

Staphylococcal manipulation of host immune responses. Nat Rev Microbiol (2015) 1.42

Pathogenesis of Staphylococcus aureus abscesses. Am J Pathol (2015) 1.00

Neutrophil-Mediated Phagocytosis of Staphylococcus aureus. Front Immunol (2014) 0.93

Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun (2015) 0.90

Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus. Pathogens (2015) 0.85

MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence. Sci Rep (2015) 0.83

Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions. PLoS Genet (2016) 0.82

Extracellular traps and macrophages: new roles for the versatile phagocyte. J Leukoc Biol (2015) 0.81

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog (2016) 0.80

Novel Evasion Mechanisms of the Classical Complement Pathway. J Immunol (2016) 0.80

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link. Semin Immunol (2016) 0.77

Evasion of Neutrophil Killing by Staphylococcus aureus. Pathogens (2016) 0.77

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. PLoS Pathog (2016) 0.76

The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis. Microbiology (2016) 0.76

Immunization routes in cattle impact the levels and neutralizing capacity of antibodies induced against S. aureus immune evasion proteins. Vet Res (2015) 0.76

Early cytokine release in response to live Borrelia burgdorferi Sensu Lato Spirochetes is largely complement independent. PLoS One (2014) 0.76

Complement system in dermatological diseases - fire under the skin. Front Med (Lausanne) (2015) 0.76

Coagulase and Efb of Staphylococcus aureus Have a Common Fibrinogen Binding Motif. MBio (2016) 0.76

Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. J Immunol (2015) 0.76

Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer. Clin Immunol (2015) 0.75

Neutrophils and Immunity: From Bactericidal Action to Being Conquered. J Immunol Res (2017) 0.75

Staphylococcus aureus Aggregation and Coagulation Mechanisms, and Their Function in Host-Pathogen Interactions. Adv Appl Microbiol (2016) 0.75

Fibrinogen Is at the Interface of Host Defense and Pathogen Virulence in Staphylococcus aureus Infection. Semin Thromb Hemost (2016) 0.75

Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection. Nat Commun (2017) 0.75

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus. Sci Rep (2017) 0.75

The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. mSphere (2016) 0.75

A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo. Microb Biotechnol (2017) 0.75

Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes. J Biol Chem (2015) 0.75

Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus. Front Cell Infect Microbiol (2017) 0.75

Thymus vulgaris L. and thymol assist murine macrophages (RAW 264.7) in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Immunol Res (2017) 0.75

Articles cited by this

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol (2006) 12.29

Complement. First of two parts. N Engl J Med (2001) 11.16

Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37

sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J Bacteriol (2002) 6.71

Ligand binding to integrins. J Biol Chem (2000) 4.94

Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A (2009) 3.89

Cryosectioning and immunolabeling. Nat Protoc (2007) 3.23

Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J (2009) 2.82

Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood (2002) 2.62

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest (2004) 2.57

Complement: a unique innate immune sensor for danger signals. Mol Immunol (2004) 2.42

Antibody orientation at bacterial surfaces is related to invasive infection. J Exp Med (2012) 2.30

Staphylococcus aureus serotype 5 capsular polysaccharide is antiphagocytic and enhances bacterial virulence in a murine bacteremia model. Infect Immun (1998) 2.29

Complement driven by conformational changes. Nat Rev Immunol (2008) 2.21

Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98

A structural basis for complement inhibition by Staphylococcus aureus. Nat Immunol (2007) 1.95

Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions. BMC Microbiol (2010) 1.92

Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense. Blood (2011) 1.87

agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun (2010) 1.77

SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76

Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog (2010) 1.75

The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74

Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis (2004) 1.62

Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Blood (2007) 1.47

Vaccination and passive immunisation against Staphylococcus aureus. Int J Antimicrob Agents (2008) 1.46

Lack of the extracellular 19-kilodalton fibrinogen-binding protein from Staphylococcus aureus decreases virulence in experimental wound infection. Infect Immun (1996) 1.46

Staphylococcus aureus interactions with the endothelium: the role of bacterial "secretable expanded repertoire adhesive molecules" (SERAM) in disturbing host defense systems. Thromb Haemost (2005) 1.44

The contact system--a novel branch of innate immunity generating antibacterial peptides. EMBO J (2006) 1.36

Multiple binding sites in the interaction between an extracellular fibrinogen-binding protein from Staphylococcus aureus and fibrinogen. J Biol Chem (1998) 1.32

Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun (2012) 1.07

Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain. J Biol Chem (2001) 1.04

Crystallization of fragment D from human fibrinogen. Protein Sci (1995) 1.02

Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model. PLoS Pathog (2012) 1.01

Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence. J Biol Chem (2011) 0.99

Staphylococcus aureus induces release of bradykinin in human plasma. Infect Immun (2001) 0.99

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. PLoS One (2012) 0.98

Extracellular fibrinogen binding protein, Efb, from Staphylococcus aureus binds to platelets and inhibits platelet aggregation. Thromb Haemost (2004) 0.92

Exploring Staphylococcus aureus pathways to disease for vaccine development. Semin Immunopathol (2011) 0.90

Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses. J Innate Immun (2012) 0.89

Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain. FEMS Microbiol Lett (2010) 0.88

Protective immunization against Staphylococcus aureus infection in a novel experimental wound model in mice. APMIS (2012) 0.79