Published in J Neurochem on August 19, 2010
Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet (2010) 1.21
Emerging roles of the neuronal nucleolus. Trends Neurosci (2012) 1.18
Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity. PLoS One (2011) 0.97
Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage. Mol Biol Cell (2011) 0.95
Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair. J Biol Chem (2011) 0.91
Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms. Hum Mol Genet (2014) 0.90
Compensatory Motor Neuron Response to Chromatolysis in the Murine hSOD1(G93A) Model of Amyotrophic Lateral Sclerosis. Front Cell Neurosci (2014) 0.81
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
Inhibitors of histone deacetylases enhance neurotoxicity of DNA damage. Neuromolecular Med (2014) 0.79
Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival. J Ocul Biol Dis Infor (2012) 0.79
Chronic phencyclidine increases synapsin-1 and synaptic adaptation proteins in the medial prefrontal cortex. ISRN Psychiatry (2013) 0.77
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target? Mech Ageing Dev (2016) 0.75
Neuroprotection Mediated by P2Y13 Nucleotide Receptors in Neurons. Comput Struct Biotechnol J (2015) 0.75
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem (2001) 12.53
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
Nucleolar proteome dynamics. Nature (2005) 7.32
Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol (2008) 7.00
Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene. Nature (2004) 6.83
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev (2008) 6.57
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science (2002) 6.29
Transcription of eukaryotic protein-coding genes. Annu Rev Genet (2000) 6.12
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J (2003) 5.48
The many pathways of RNA degradation. Cell (2009) 5.31
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat Cell Biol (2005) 4.13
Single-strand break repair and genetic disease. Nat Rev Genet (2008) 4.07
Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev (2003) 3.85
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol (2008) 3.42
The aging brain. Annu Rev Pathol (2008) 3.28
Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer (2007) 3.12
Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci (2006) 3.06
Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs. Nature (2008) 2.78
Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu Rev Neurosci (2007) 2.59
Defective DNA repair and neurodegenerative disease. Cell (2007) 2.57
Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol (2002) 2.55
The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components. Genes Dev (2006) 2.46
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol (2010) 2.45
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One (2008) 2.40
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature (2007) 2.30
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem (1999) 2.25
Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23
Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science (1991) 2.17
Sensing cellular stress: another new function for the nucleolus? Sci STKE (2004) 2.09
Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell (2009) 1.97
Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res (2008) 1.96
Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol Aging (2003) 1.93
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nat Rev Drug Discov (2007) 1.92
RNA polymerases I and III, non-coding RNAs and cancer. Trends Genet (2008) 1.91
Transcriptional signatures in Huntington's disease. Prog Neurobiol (2007) 1.86
Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem (2004) 1.81
Eukaryotic snoRNAs: a paradigm for gene expression flexibility. Genomics (2009) 1.79
Aging and gene expression in the primate brain. PLoS Biol (2005) 1.76
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem J (2005) 1.70
RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis? Chem Rev (2006) 1.67
Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity. Neurobiol Dis (2005) 1.65
Complexity and characterization of polyadenylated RNA in the mouse brain. Cell (1976) 1.62
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr Drug Targets CNS Neurol Disord (2005) 1.62
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem (2005) 1.61
RPA and ATR link transcriptional stress to p53. Proc Natl Acad Sci U S A (2007) 1.61
Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp Cell Res (2007) 1.60
Astrocyte responses to CNS injury. J Neuropathol Exp Neurol (1994) 1.57
Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta (2006) 1.54
Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer Lett (2006) 1.53
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J (2002) 1.52
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J Neurosci (2002) 1.51
The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair. DNA Repair (Amst) (2008) 1.50
Bax involvement in p53-mediated neuronal cell death. J Neurosci (1998) 1.48
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.47
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev Biol (1990) 1.46
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol (1996) 1.44
Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem (2004) 1.44
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem J (2008) 1.42
MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis. Kidney Int (2005) 1.41
Ribosomal DNA contributes to global chromatin regulation. Proc Natl Acad Sci U S A (2009) 1.40
Expression of human snRNA genes from beginning to end. Biochem Soc Trans (2008) 1.39
Neurologic complications of chemotherapy agents. Curr Opin Neurol (2007) 1.39
Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts. J Biol Chem (2004) 1.36
The assembly of a spliceosomal small nuclear ribonucleoprotein particle. Nucleic Acids Res (2008) 1.34
Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line. J Biol Chem (2001) 1.33
The role of the DNA damage response in neuronal development, organization and maintenance. DNA Repair (Amst) (2008) 1.32
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
DNA oxidation in Alzheimer's disease. Antioxid Redox Signal (2006) 1.31
DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27
The role of poly(ADP-ribose) polymerase-1 in CNS disease. Neuroscience (2006) 1.27
DNA damage and repair: relevance to mechanisms of neurodegeneration. J Neuropathol Exp Neurol (2008) 1.25
MicroRNA biogenesis: there's more than one way to skin a cat. Biochim Biophys Acta (2008) 1.23
Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons. J Biol Chem (2004) 1.21
A single 8,5'-cyclo-2'-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo. DNA Repair (Amst) (2002) 1.21
The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathol Appl Neurobiol (1988) 1.19
Signaling mechanisms underlying dendrite formation. Curr Opin Neurobiol (2003) 1.18
Effect of oxidative DNA damage in promoter elements on transcription factor binding. Nucleic Acids Res (1999) 1.14
When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease. Bioessays (2003) 1.13
The effects of cisplatin on rat spinal ganglia: a study by light and electron microscopy and by morphometry. Acta Neuropathol (1986) 1.12
Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci (2008) 1.12
A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. Eur J Neurosci (2004) 1.12
Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase. Nat Cell Biol (2006) 1.10
Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy. J Neurosci (2007) 1.10
The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription. Carcinogenesis (1996) 1.10
Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death. Oncogene (2006) 1.09
Extracellular signals and scores of phosphatases: all roads lead to MAP kinase. Semin Immunol (2000) 1.08
Age-associated changes in the DNA of mouse tissue. Science (1971) 1.07
Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem (2008) 1.06
Transcription of nonrepeated DNA in mouse brain. Science (1971) 1.06
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncol (2008) 1.10
Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS One (2011) 1.07
Model selection in logistic joinpoint regression with applications to analyzing cohort mortality patterns. Stat Med (2008) 0.95
Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype. Hum Mol Genet (2010) 0.94
Glucan and resveratrol complex--possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (2007) 0.90
Immunological effects of yeast- and mushroom-derived beta-glucans. J Med Food (2008) 0.88
Depletion of procathepsin D gene expression by RNA interference: a potential therapeutic target for breast cancer. Cancer Biol Ther (2007) 0.84
Procathepsin D and cancer: From molecular biology to clinical applications. World J Clin Oncol (2010) 0.83
New 4-deoxy-(1→3)-β-D-glucan-based oligosaccharides and their immunostimulating potential. Carbohydr Res (2011) 0.82
Vinyl chloride and liver and brain cancer at a polymer production plant in Louisville, Kentucky. J Occup Environ Med (2003) 0.80
Effect of procathepsin D activation peptide on gene expression of breast cancer cells. Cancer Lett (2005) 0.79
2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231. Oncol Rep (2008) 0.79
Comprehensive Evaluation of Anti-hyperglycemic Activity of Fractionated Momordica charantia Seed Extract in Alloxan-Induced Diabetic Rats. Evid Based Complement Alternat Med (2012) 0.79
Biological properties of (1 → 3)-β-D-glucan-based synthetic oligosaccharides. J Med Food (2010) 0.79
A case-cohort study of angiosarcoma of the liver and brain cancer at a polymer production plant. J Occup Environ Med (2003) 0.79
Procathepsin D expression correlates with invasive and metastatic phenotype of MDA-MB-231 derived cell lines. Int J Biol Macromol (2007) 0.78
Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases. J Neurochem (2008) 0.78
The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids. J Med Food (2013) 0.75
Procathepsin d involvement in chemoresistance of cancer cells. N Am J Med Sci (2012) 0.75
Oligo-β-(1 → 3)-glucans: impact of thio-bridges on immunostimulating activities and the development of cancer stem cells. J Med Chem (2014) 0.75