DNA topoisomerases: structure, function, and mechanism.

Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88

Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob Agents Chemother (2005) 4.03

Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol Syst Biol (2007) 3.98

The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A (2002) 3.71

Topological domain structure of the Escherichia coli chromosome. Genes Dev (2004) 3.30

DNA topoisomerase II and its growing repertoire of biological functions. Nat Rev Cancer (2009) 3.05

SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell (2009) 2.73

DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition. Chem Rev (2009) 2.65

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64

High-resolution structure of the E.coli RecQ helicase catalytic core. EMBO J (2003) 2.61

Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli. Genome Biol (2004) 2.60

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc Natl Acad Sci U S A (2002) 2.50

Drugging topoisomerases: lessons and challenges. ACS Chem Biol (2013) 2.46

The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. Mol Cell Biol (2007) 2.41

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature (2009) 2.33

Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes. Antimicrob Agents Chemother (2006) 2.32

Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol (2006) 2.16

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Mol Cell (2009) 2.12

Long-term experimental evolution in Escherichia coli. XII. DNA topology as a key target of selection. Genetics (2004) 2.10

A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli. Genome Res (2003) 2.10

Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. Proc Natl Acad Sci U S A (2005) 2.04

Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis. Genome Dyn Stab (2008) 2.03

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. J Biol Chem (2005) 1.96

DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95

The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity. EMBO J (2005) 1.88

Clearing the way for mitosis: is cohesin a target? Nat Rev Mol Cell Biol (2009) 1.88

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. Appl Microbiol Biotechnol (2011) 1.85

Mechanochemical analysis of DNA gyrase using rotor bead tracking. Nature (2006) 1.83

Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82

Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics (2002) 1.79

A topological view of the replicon. EMBO Rep (2004) 1.76

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res (2011) 1.76

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev (2007) 1.75

Quinolones: from antibiotics to autoinducers. FEMS Microbiol Rev (2011) 1.75

Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell (2015) 1.74

The triple helix: 50 years later, the outcome. Nucleic Acids Res (2008) 1.73

Quinolones: action and resistance updated. Curr Top Med Chem (2009) 1.73

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nat Rev Cancer (2009) 1.71

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2010) 1.68

Decatenation of DNA circles by FtsK-dependent Xer site-specific recombination. EMBO J (2003) 1.64

Mismatch repair deficient colorectal cancer in the era of personalized treatment. Nat Rev Clin Oncol (2010) 1.62

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast. Proc Natl Acad Sci U S A (2010) 1.61

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription. Cell (2016) 1.57

DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55

Resolution of converging replication forks by RecQ and topoisomerase III. Mol Cell (2008) 1.55

Bacterial topoisomerase I as a target for discovery of antibacterial compounds. Nucleic Acids Res (2008) 1.55

Human DNA topoisomerase I: relaxation, roles, and damage control. Chromosoma (2005) 1.51

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem (2010) 1.50

Helicobacter Pylori's plasticity zones are novel transposable elements. PLoS One (2009) 1.48

BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J (2004) 1.48

A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics (2005) 1.46

The mechanism of type IA topoisomerases. Proc Natl Acad Sci U S A (2002) 1.43

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy. Anticancer Agents Med Chem (2008) 1.43

DNA topoisomerase 1α promotes transcriptional silencing of transposable elements through DNA methylation and histone lysine 9 dimethylation in Arabidopsis. PLoS Genet (2014) 1.41

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival. J Clin Oncol (2010) 1.40

DNA reshaping by MukB. Right-handed knotting, left-handed supercoiling. J Biol Chem (2005) 1.40

Global transcriptome analysis of the cold shock response of Shewanella oneidensis MR-1 and mutational analysis of its classical cold shock proteins. J Bacteriol (2006) 1.40

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol (2005) 1.40

Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases. EMBO J (2006) 1.39

Mechanisms of chiral discrimination by topoisomerase IV. Proc Natl Acad Sci U S A (2009) 1.38

Quinolone-binding pocket of DNA gyrase: role of GyrB. Antimicrob Agents Chemother (2002) 1.38

DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia. PLoS Negl Trop Dis (2013) 1.38

Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA. EMBO J (2002) 1.38

Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA. EMBO J (2006) 1.38

Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase. Nucleic Acids Res (2002) 1.37

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J Cell Biol (2011) 1.36

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36

Fast dynamics of supercoiled DNA revealed by single-molecule experiments. Proc Natl Acad Sci U S A (2007) 1.35

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase. PLoS One (2010) 1.35

Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother (2002) 1.34

Mechanism of quinolone action and resistance. Biochemistry (2014) 1.34

Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A (2003) 1.33

Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria. Proc Natl Acad Sci U S A (2004) 1.32

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J (2009) 1.32

Effects of magnesium and related divalent metal ions in topoisomerase structure and function. Nucleic Acids Res (2009) 1.32

A poxvirus-like type IB topoisomerase family in bacteria. Proc Natl Acad Sci U S A (2002) 1.31

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. J Biol Chem (2008) 1.31

SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by the sumoylation of topoisomerase II. Genetics (2005) 1.30

Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. J Biol Chem (2011) 1.29

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One (2010) 1.29

Topoisomerase I regulates open chromatin and controls gene expression in vivo. EMBO J (2010) 1.28

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem (2012) 1.26

Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol (2011) 1.25

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Sci Signal (2010) 1.25

Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases. Antimicrob Agents Chemother (2008) 1.25

Cellular strategies for regulating DNA supercoiling: a single-molecule perspective. Cell (2010) 1.25

Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms. Nucleic Acids Res (2009) 1.25

Structural studies of type I topoisomerases. Nucleic Acids Res (2008) 1.24

From bench to drug: human seizure modeling using Drosophila. Prog Neurobiol (2007) 1.24

Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res (2010) 1.24

Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV. Antimicrob Agents Chemother (2009) 1.24

Recombination and chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2004) 1.24

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci U S A (2010) 1.23

Genetics of Borrelia burgdorferi. Annu Rev Genet (2012) 1.21

Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. Proc Natl Acad Sci U S A (2002) 1.19

Topoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanism. Proc Natl Acad Sci U S A (2007) 1.18

Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J (2003) 1.18

Protein design: toward functional metalloenzymes. Chem Rev (2014) 1.17