Published in Annu Rev Cell Dev Biol on January 01, 2008
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83
The nucleolus under stress. Mol Cell (2010) 3.63
Long noncoding RNAs: past, present, and future. Genetics (2013) 3.16
Biogenesis and function of nuclear bodies. Trends Genet (2011) 2.60
Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci (2012) 2.46
Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nat Rev Genet (2011) 2.39
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell (2012) 2.29
Nuclear neighborhoods and gene expression. Curr Opin Genet Dev (2009) 2.21
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol (2010) 1.93
Chromosome crosstalk in three dimensions. Nature (2009) 1.91
Initial genomics of the human nucleolus. PLoS Genet (2010) 1.71
High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell (2010) 1.56
Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell (2009) 1.52
Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomes. Eukaryot Cell (2009) 1.51
Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome. Cell Rep (2016) 1.45
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell (2014) 1.35
Mechanisms of HDA6-mediated rRNA gene silencing: suppression of intergenic Pol II transcription and differential effects on maintenance versus siRNA-directed cytosine methylation. Genes Dev (2010) 1.34
Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat Rev Cancer (2013) 1.26
Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics (2011) 1.22
Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol (2009) 1.20
Nucleolar dominance and ribosomal RNA gene silencing. Curr Opin Cell Biol (2010) 1.19
Long noncoding RNAs: an emerging link between gene regulation and nuclear organization. Trends Cell Biol (2014) 1.19
Integrative genomic analysis of human ribosomal DNA. Nucleic Acids Res (2011) 1.18
Emerging roles of the neuronal nucleolus. Trends Neurosci (2012) 1.18
Long-Range Chromatin Interactions. Cold Spring Harb Perspect Biol (2015) 1.16
Dysregulation of RNA polymerase I transcription during disease. Biochim Biophys Acta (2012) 1.16
Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states. Genes Dev (2013) 1.15
The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma (2013) 1.14
Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division. Genes Dev (2014) 1.14
Dicer is associated with ribosomal DNA chromatin in mammalian cells. PLoS One (2010) 1.14
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet (2010) 1.13
Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. J Cell Biol (2010) 1.08
Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS One (2011) 1.07
CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin (2010) 1.06
Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res (2012) 1.05
Allelic inactivation of rDNA loci. Genes Dev (2009) 1.04
The shared genomic architecture of human nucleolar organizer regions. Genome Res (2013) 1.03
Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription. J Cell Biochem (2010) 1.01
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation. Nucleic Acids Res (2010) 1.01
The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. PLoS One (2011) 1.00
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes. Proc Natl Acad Sci U S A (2010) 1.00
Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation. J Mol Cell Biol (2014) 1.00
Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation. Oncogene (2011) 0.99
SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription. EMBO Rep (2013) 0.99
Histone methyltransferases regulating rRNA gene dose and dosage control in Arabidopsis. Genes Dev (2012) 0.99
Expression of I-CreI endonuclease generates deletions within the rDNA of Drosophila. Genetics (2009) 0.97
Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep (2011) 0.95
Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal (2013) 0.95
Nucleolar DNA: the host and the guests. Histochem Cell Biol (2016) 0.95
Something silent this way forms: the functional organization of the repressive nuclear compartment. Annu Rev Cell Dev Biol (2013) 0.95
Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet (2014) 0.95
Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Proc Natl Acad Sci U S A (2015) 0.95
Nucleolar follistatin promotes cancer cell survival under glucose-deprived conditions through inhibiting cellular rRNA synthesis. J Biol Chem (2010) 0.94
Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression. PLoS Genet (2013) 0.94
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem (2013) 0.94
Morphology of nuclear transcription. Histochem Cell Biol (2016) 0.94
macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res (2013) 0.94
Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease. Cell Biosci (2014) 0.93
Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments. J Histochem Cytochem (2009) 0.93
Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc Natl Acad Sci U S A (2010) 0.92
Chromosome-specific NOR inactivation explains selective rRNA gene silencing and dosage control in Arabidopsis. Genes Dev (2016) 0.92
MYC regulation of cell growth through control of transcription by RNA polymerases I and III. Cold Spring Harb Perspect Med (2014) 0.91
TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes. Nucleic Acids Res (2013) 0.91
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc Natl Acad Sci U S A (2012) 0.89
Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease. Cell Death Differ (2011) 0.89
SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions. Chromosoma (2009) 0.89
The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes. PLoS One (2011) 0.89
An intranucleolar body associated with rDNA. Chromosoma (2011) 0.89
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Mol Cell Biol (2013) 0.89
Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition. J Neurochem (2010) 0.88
A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation. J Cell Sci (2012) 0.88
Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin. Epigenetics Chromatin (2011) 0.87
Transgenerational inheritance of diet-induced genome rearrangements in Drosophila. PLoS Genet (2015) 0.87
Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. PLoS One (2012) 0.87
Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo. Sci Rep (2016) 0.87
Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterations. PLoS One (2012) 0.87
Altered bivalent positioning in metaphase I human spermatocytes from Robertsonian translocation carriers. J Assist Reprod Genet (2016) 0.86
Nucleolar responses to DNA double-strand breaks. Nucleic Acids Res (2015) 0.86
An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells. PLoS One (2009) 0.86
Large-scale organization of ribosomal DNA chromatin is regulated by Tip5. Nucleic Acids Res (2013) 0.85
A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei. Nucleic Acids Res (2015) 0.84
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes. Genome Res (2014) 0.84
Nucleolar dysfunction in Huntington's disease. Biochim Biophys Acta (2013) 0.84
DNA sequence encoded repression of rRNA gene transcription in chromatin. Nucleic Acids Res (2010) 0.84
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments. J Gen Virol (2009) 0.83
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biol (2014) 0.83
Insights into epigenetic landscape of recombination-free regions. Chromosoma (2016) 0.82
Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter. J Cell Physiol (2014) 0.82
Functional ultrastructure of the plant nucleolus. Protoplasma (2014) 0.82
Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states. Ann N Y Acad Sci (2010) 0.82
A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Mol Biol Cell (2014) 0.82
Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression. J Cell Physiol (2011) 0.82
Epigeneitc silencing of ribosomal RNA genes by Mybbp1a. J Biomed Sci (2012) 0.82
The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas. BMC Cancer (2014) 0.82
NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape. Sci Rep (2015) 0.81
HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs. Epigenetics Chromatin (2014) 0.81
Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther (2014) 0.81
Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. Mol Cell Biol (2011) 0.81
Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res (2017) 0.81
A kinetic framework for a mammalian RNA polymerase in vivo. Science (2002) 4.42
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol (2005) 3.79
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet (2002) 3.58
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev (2010) 2.96
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol Cell (2006) 2.89
Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol (2004) 2.49
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol (2010) 2.45
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J (2002) 2.36
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev (2005) 2.13
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell (2003) 1.98
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell (2009) 1.97
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell (2007) 1.96
CSB is a component of RNA pol I transcription. Mol Cell (2002) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
Cellular stress and nucleolar function. Cell Cycle (2005) 1.88
Identification of novel functional TBP-binding sites and general factor repertoires. EMBO J (2007) 1.77
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol (2005) 1.75
Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation. Mol Cell Biol (2005) 1.66
The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. EMBO Rep (2008) 1.64
Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev (2008) 1.63
The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep (2006) 1.59
The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres. EMBO Rep (2013) 1.55
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep (2002) 1.48
Modulation of RNA polymerase assembly dynamics in transcriptional regulation. Mol Cell (2008) 1.47
TFIIH plays an essential role in RNA polymerase I transcription. Cell (2002) 1.43
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucleic Acids Res (2007) 1.42
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol Cell (2013) 1.41
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 1.40
NoRC-dependent nucleosome positioning silences rRNA genes. EMBO J (2006) 1.39
NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells (2013) 1.35
The chromatin remodeling complex NoRC controls replication timing of rRNA genes. EMBO J (2004) 1.34
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol (2009) 1.30
Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci (2011) 1.20
The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. Nucleic Acids Res (2004) 1.16
Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin. Mol Cell Biol (2004) 1.15
The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma (2013) 1.14
The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U S A (2012) 1.13
Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci (2008) 1.12
Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol (2008) 1.10
Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans. EMBO Rep (2009) 1.05
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS One (2011) 1.01
Proteasomal ATPases are associated with rDNA: the ubiquitin proteasome system plays a direct role in RNA polymerase I transcription. Biochim Biophys Acta (2008) 0.94
Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I. Nucleic Acids Res (2006) 0.94
A model for the topology of active ribosomal RNA genes. EMBO Rep (2011) 0.93
Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Mol Cell Biol (2004) 0.91
Linking rDNA transcription to the cellular energy supply. Cell Cycle (2010) 0.90
Identification of protein phosphorylation sites by combination of elastase digestion, immobilized metal affinity chromatography, and quadrupole-time of flight tandem mass spectrometry. Proteomics (2002) 0.88
Development of a species-specific RNA polymerase I-based shRNA expression vector. Nucleic Acids Res (2006) 0.86
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. Proc Natl Acad Sci U S A (2007) 0.84
DNA sequence encoded repression of rRNA gene transcription in chromatin. Nucleic Acids Res (2010) 0.84
Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress. Biochim Biophys Acta (2009) 0.80
Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites. PLoS Genet (2013) 0.79
Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase. Biol Chem (2002) 0.79
Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response. J Rheumatol (2002) 0.75