Published in Int J Epidemiol on February 01, 2003
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol (2012) 6.91
Gene--environment-wide association studies: emerging approaches. Nat Rev Genet (2010) 6.10
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (2010) 5.31
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol (2009) 4.70
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ (2014) 4.69
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One (2010) 4.42
Phenomics: the next challenge. Nat Rev Genet (2010) 4.20
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94
Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet (2007) 3.92
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81
Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol (2012) 3.77
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med (2007) 3.71
Illustrating bias due to conditioning on a collider. Int J Epidemiol (2009) 3.54
An atlas of genetic influences on human blood metabolites. Nat Genet (2014) 3.21
The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr (2008) 3.18
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13
Mendelian randomisation and causal inference in observational epidemiology. PLoS Med (2008) 3.12
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Data dredging, bias, or confounding. BMJ (2002) 2.87
Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res (2011) 2.83
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol (2015) 2.78
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet (2010) 2.76
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ (2014) 2.72
Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. PLoS Med (2008) 2.61
Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet (2014) 2.58
What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int J Epidemiol (2011) 2.54
Psychosocial factors and public health: a suitable case for treatment? J Epidemiol Community Health (2003) 2.53
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health (2007) 2.50
What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ (2005) 2.50
Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ (2013) 2.41
Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med (2015) 2.40
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study. PLoS One (2008) 2.37
Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol (2013) 2.34
Proximal, distal, and the politics of causation: what's level got to do with it? Am J Public Health (2008) 2.21
Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med (2010) 2.20
Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol (2008) 2.20
Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. Stat Med (2009) 2.19
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med (2008) 2.16
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension (2008) 2.14
Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol (2015) 2.14
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol (2012) 2.12
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 2.10
The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoS Med (2012) 2.09
Risk of esophageal adenocarcinoma decreases with height, based on consortium analysis and confirmed by Mendelian randomization. Clin Gastroenterol Hepatol (2014) 2.07
Empirical efficiency maximization: improved locally efficient covariate adjustment in randomized experiments and survival analysis. Int J Biostat (2008) 2.06
Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol (2013) 2.06
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
Causal relationship between the AHSG gene and BMD through fetuin-A and BMI: multiple mediation analysis. Osteoporos Int (2014) 2.02
How does body fat influence bone mass in childhood? A Mendelian randomization approach. J Bone Miner Res (2009) 2.01
Prospects for epigenetic epidemiology. Am J Epidemiol (2009) 2.00
Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biol (2007) 1.94
Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome. BMC Syst Biol (2008) 1.93
Genetics of human cardiovascular disease. Cell (2012) 1.90
Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet (2016) 1.90
Genetic epidemiology and primary care. Br J Gen Pract (2006) 1.89
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health (2010) 1.88
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype. Int J Epidemiol (2009) 1.87
Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol (2013) 1.87
Disentangling molecular relationships with a causal inference test. BMC Genet (2009) 1.84
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst (2012) 1.83
Schizophrenia. Lancet (2016) 1.83
A unified framework for association analysis with multiple related phenotypes. PLoS One (2013) 1.81
Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study. J Natl Cancer Inst (2014) 1.81
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis (2009) 1.78
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. Eur Heart J (2008) 1.76
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J (2011) 1.73
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort. Eur J Epidemiol (2006) 1.69
The Promises and Pitfalls of Genoeconomics* Annu Rev Econom (2012) 1.66
Capitalizing on Mendelian randomization to assess the effects of treatments. J R Soc Med (2007) 1.66
Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk. Cancer Res (2009) 1.65
Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. Genes Nutr (2010) 1.65
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr (2010) 1.61
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61
Methodological challenges in mendelian randomization. Epidemiology (2014) 1.61
IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children. Biol Psychiatry (2011) 1.59
Instrumental variable analysis with a nonlinear exposure-outcome relationship. Epidemiology (2014) 1.58
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet (2014) 1.58
Emerging risk factors and markers of chronic kidney disease progression. Nat Rev Nephrol (2009) 1.58
G = E: What GWAS Can Tell Us about the Environment. PLoS Genet (2016) 1.57
Instrumental variables II: instrumental variable application-in 25 variations, the physician prescribing preference generally was strong and reduced covariate imbalance. J Clin Epidemiol (2009) 1.56
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? PLoS Med (2009) 1.54
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond) (2010) 1.53
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet (2016) 1.52
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol (2015) 1.51
Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. Cancer Prev Res (Phila) (2009) 1.51
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol (2016) 1.49
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Priority actions for the non-communicable disease crisis. Lancet (2011) 15.18
European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J (2003) 8.51
Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med (2004) 8.07
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence? Lancet (2004) 6.37
European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil (2007) 6.10
Where is the evidence that animal research benefits humans? BMJ (2004) 5.99
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev (2013) 5.57
Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review). Am J Hypertens (2011) 5.54
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet (2005) 5.51
Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev (2011) 5.30
Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol (2004) 5.07
Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis. Lancet (2008) 4.97
Predictive accuracy of the Framingham coronary risk score in British men: prospective cohort study. BMJ (2003) 4.74
Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev (2011) 4.72
The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection. Lancet Infect Dis (2007) 4.34
Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care. Lancet (2008) 4.32
Chronic diseases and injuries in India. Lancet (2011) 4.27
Raising the priority of preventing chronic diseases: a political process. Lancet (2010) 4.16
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Prevention of chronic diseases: a call to action. Lancet (2007) 3.87
Systematic review of long term effects of advice to reduce dietary salt in adults. BMJ (2002) 3.87
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med (2007) 3.71
NHS waiting lists and evidence of national or local failure: analysis of health service data. BMJ (2003) 3.60
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
(Mis)use of factor analysis in the study of insulin resistance syndrome. Am J Epidemiol (2004) 3.43
European guidelines on cardiovascular disease prevention in clinical practice: third joint task force of European and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of eight societies and by invited experts). Eur J Cardiovasc Prev Rehabil (2003) 3.43
Lessons from the withdrawal of rofecoxib. BMJ (2004) 3.33
Secular trends in mortality by stroke subtype in the 20th century: a retrospective analysis. Lancet (2002) 3.29
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Chronic diseases and calls to action. Int J Epidemiol (2008) 3.11
WHO study on Prevention of REcurrences of Myocardial Infarction and StrokE (WHO-PREMISE). Bull World Health Organ (2005) 3.09
Non-communicable diseases in low and middle-income countries: a priority or a distraction? Int J Epidemiol (2005) 3.06
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Genetic epidemiology and public health: hope, hype, and future prospects. Lancet (2005) 3.00
Admissions for myocardial infarction and World Cup football: database survey. BMJ (2002) 2.99
Evaluating the impact of population and high-risk strategies for the primary prevention of cardiovascular disease. Eur Heart J (2004) 2.91
How can we improve adherence to blood pressure-lowering medication in ambulatory care? Systematic review of randomized controlled trials. Arch Intern Med (2004) 2.89
Data dredging, bias, or confounding. BMJ (2002) 2.87
Educational and organisational interventions used to improve the management of hypertension in primary care: a systematic review. Br J Gen Pract (2005) 2.83
Comparison of the associations of body mass index and measures of central adiposity and fat mass with coronary heart disease, diabetes, and all-cause mortality: a study using data from 4 UK cohorts. Am J Clin Nutr (2010) 2.82
Manufacturing epidemics: the role of global producers in increased consumption of unhealthy commodities including processed foods, alcohol, and tobacco. PLoS Med (2012) 2.71
European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil (2007) 2.70
Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control (2008) 2.68
Association between falls in elderly women and chronic diseases and drug use: cross sectional study. BMJ (2003) 2.63
What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ (2005) 2.50
A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health (2007) 2.50
Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis. Arterioscler Thromb Vasc Biol (2007) 2.45
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44
Cost-effectiveness of community-based strategies for blood pressure control in a low-income developing country: findings from a cluster-randomized, factorial-controlled trial. Circulation (2011) 2.44
The association between orthostatic hypotension and medication use in the British Women's Heart and Health Study. Age Ageing (2009) 2.43
Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol (2005) 2.42
Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2011) 2.38
Folate supplementation and cardiovascular disease. Lancet (2005) 2.36
Hypertension among older adults in low- and middle-income countries: prevalence, awareness and control. Int J Epidemiol (2014) 2.33
Does psychological distress predict the risk of ischemic stroke and transient ischemic attack? The Caerphilly Study. Stroke (2002) 2.30
Fixed-dose combination therapy for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2014) 2.24
Smoking and ill health: does lay epidemiology explain the failure of smoking cessation programs among deprived populations? Am J Public Health (2003) 2.23
Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. Diabetes Care (2009) 2.23
Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men. Stroke (2004) 2.22
Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross sectional study. BMJ (2010) 2.21
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Balancing benefits and harms: the example of non-steroidal anti-inflammatory drugs. BMJ (2004) 2.12
Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2014) 2.10
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
Fasting blood glucose and the risk of stroke and myocardial infarction. Circulation (2009) 1.92
Is stroke the most common cause of disability? J Stroke Cerebrovasc Dis (2007) 1.92
Statin therapy for primary prevention of cardiovascular disease. JAMA (2013) 1.87
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst (2012) 1.83
Palm oil taxes and cardiovascular disease mortality in India: economic-epidemiologic model. BMJ (2013) 1.81
Agreement between measured and self-reported weight in older women. Results from the British Women's Heart and Health Study. Age Ageing (2002) 1.78
Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women. J Clin Endocrinol Metab (2005) 1.74
Association of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study. BMJ (2003) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer (2008) 1.67
Sedentary behaviors and the risk of incident hypertension: the SUN Cohort. Am J Hypertens (2007) 1.61
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr (2010) 1.61
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol (2011) 1.61
The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J (2006) 1.57
Prevention and control of chronic diseases. BMJ (2010) 1.56
STROBE: new standards for reporting observational epidemiology, a chance to improve. Int J Epidemiol (2007) 1.54