Published in Mol Biotechnol on November 01, 2010
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46
A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? Biotechnol Bioeng (2009) 1.45
The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering. Biomaterials (2008) 1.30
Mechanisms of protein stabilization and prevention of protein aggregation by glycerol. Biochemistry (2009) 1.28
Stem cell bioprocessing: fundamentals and principles. J R Soc Interface (2009) 1.17
Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng (2012) 1.17
FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling. J Cell Physiol (2010) 1.14
Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. Expert Opin Investig Drugs (2009) 1.13
The benefit of human embryonic stem cell encapsulation for prolonged feeder-free maintenance. Biomaterials (2008) 1.12
Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling. Biotechnol Bioeng (2004) 1.09
TGF-beta3: A potential biological therapy for enhancing chondrogenesis. Expert Opin Biol Ther (2009) 1.07
Engineering a mimicry of bone marrow tissue ex vivo. J Biosci Bioeng (2005) 1.06
Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res (2010) 1.06
Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis. Biomaterials (2008) 1.04
Biological therapy of bone defects: the immunology of bone allo-transplantation. Expert Opin Biol Ther (2010) 1.04
More than meets the eye in bacterial cellulose: biosynthesis, bioprocessing, and applications in advanced fiber composites. Macromol Biosci (2013) 1.01
Engineering mammalian cells in bioprocessing - current achievements and future perspectives. Biotechnol Appl Biochem (2010) 0.99
A detailed understanding of the enhanced hypothermic productivity of interferon-gamma by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.98
IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines. J Biotechnol (2011) 0.97
Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng (2008) 0.94
Surface modification of natural fibers using bacteria: depositing bacterial cellulose onto natural fibers to create hierarchical fiber reinforced nanocomposites. Biomacromolecules (2008) 0.93
Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. Expert Opin Biol Ther (2012) 0.93
DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines. J Biotechnol (2010) 0.92
Application of destabilizing sequences on selection marker for improved recombinant protein productivity in CHO-DG44. Metab Eng (2007) 0.92
Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells. Tissue Eng (2007) 0.92
Nondestructive technique for the characterization of the pore size distribution of soft porous constructs for tissue engineering. Langmuir (2006) 0.91
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds. Biomaterials (2011) 0.90
Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system. Tissue Eng Part C Methods (2012) 0.90
Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment. Expert Opin Ther Targets (2013) 0.90
Proliferation rates of HepG2 cells encapsulated in alginate are increased in a microgravity environment compared with static cultures. Artif Organs (2005) 0.89
High-density transient gene expression in suspension-adapted 293 EBNA1 cells. Biotechnol Bioeng (2008) 0.89
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia. Biomaterials (2009) 0.89
Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures. Biotechnol Prog (2005) 0.89
Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture. Rapid Commun Mass Spectrom (2009) 0.89
Zinc as an insulin replacement in hybridoma cultures. Biotechnol Bioeng (2006) 0.89
Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production. Biotechnol Prog (2003) 0.88
An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding. Biotechnol Bioeng (2010) 0.88
Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments. Biotechnol Adv (2007) 0.88
Evaluation of insulin-mimetic trace metals as insulin replacements in mammalian cell cultures. Cytotechnology (2004) 0.88
Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production. J Biotechnol (2009) 0.86
Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnol Bioeng (2009) 0.86
Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells. Biotechnol Prog (2010) 0.86
Meeting report: second Singapore biologics manufacturing conference. Biotechnol J (2007) 0.86
Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther (2012) 0.85
Vector fragmentation: characterizing vector integrity in transfected clones by Southern blotting. Biotechnol Prog (2010) 0.84
Active hypothermic growth: a novel means for increasing total interferon-gamma production by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.84
The effect of hyperosmotic pressure on antibody production and gene expression in the GS-NS0 cell line. Biotechnol Appl Biochem (2004) 0.84
Modelling the Delta1/Notch1 pathway: in search of the mediator(s) of neural stem cell differentiation. PLoS One (2011) 0.84
Cross-linked bacterial cellulose networks using glyoxalization. ACS Appl Mater Interfaces (2010) 0.84
Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells. Protein Expr Purif (2010) 0.83
Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinese-hamster ovary cells. Biotechnol Appl Biochem (2008) 0.83
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. J Biotechnol (2010) 0.83
Development and analysis of a mathematical model for antibody-producing GS-NS0 cells under normal and hyperosmotic culture conditions. Biotechnol Prog (2006) 0.82
In vitro direct chondrogenesis of murine embryonic stem cells by bypassing embryoid body formation. Stem Cells Dev (2008) 0.81
Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data. Expert Opin Biol Ther (2014) 0.81
Linking genes to microbial growth kinetics: an integrated biochemical systems engineering approach. Metab Eng (2011) 0.81
Enhancement of transient gene expression by fed-batch culture of HEK 293 EBNA1 cells in suspension. Biotechnol Lett (2006) 0.80
Simvastatin induces osteogenic differentiation of murine embryonic stem cells. J Bone Miner Res (2010) 0.80
Growth hormone: does it have a therapeutic role in fracture healing? Expert Opin Investig Drugs (2009) 0.80
The regulatory logic of m-xylene biodegradation by Pseudomonas putida mt-2 exposed by dynamic modelling of the principal node Ps/Pr of the TOL plasmid. Environ Microbiol (2010) 0.79
Ex vivo mimicry of normal and abnormal human hematopoiesis. J Vis Exp (2012) 0.79
Molecular anatomy of preferential interaction coefficients by elucidating protein solvation in mixed solvents: methodology and application for lysozyme in aqueous glycerol. J Phys Chem B (2009) 0.79
Post-transcriptional regulatory elements for enhancing transient gene expression levels in mammalian cells. Methods Mol Biol (2012) 0.79
Enhanced hematopoietic differentiation toward erythrocytes from murine embryonic stem cells with HepG2-conditioned medium. Stem Cells Dev (2012) 0.79
Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures. Metab Eng (2006) 0.79
Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation. Expert Opin Investig Drugs (2013) 0.79
Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells. Stem Cell Res (2009) 0.79
Computational approach for understanding and improving GS-NS0 antibody production under hyperosmotic conditions. J Biosci Bioeng (2011) 0.79
The basic science of bone induction. Br J Oral Maxillofac Surg (2009) 0.79
Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures. Stem Cells Dev (2014) 0.79
Modeling amino acid metabolism in mammalian cells-toward the development of a model library. Biotechnol Prog (2007) 0.79
Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence. Expert Opin Investig Drugs (2009) 0.79
Translatome analysis of CHO cells to identify key growth genes. J Biotechnol (2013) 0.79
Modeling and analysis of individualized pharmacokinetics and pharmacodynamics for volatile anesthesia. IEEE Trans Biomed Eng (2013) 0.78
An oil-absorber-bioscrubber system to stabilize biotreatment of pollutants present in waste gas. Fluctuating loads of 1,2-dichloroethane. Environ Sci Technol (2006) 0.78
Stability and performance of Xanthobacter autotrophicus GJ10 during 1,2-dichloroethane biodegradation. Appl Environ Microbiol (2006) 0.78
Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells. Biotechnol Bioeng (2006) 0.78
Improving embryonic stem cell expansion through the combination of perfusion and Bioprocess model design. PLoS One (2013) 0.78
The incorporation of 70s bioactive glass to the osteogenic differentiation of murine embryonic stem cells in 3D bioreactors. J Tissue Eng Regen Med (2009) 0.77
Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. Biotechnol Prog (2009) 0.77
Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media. J Biotechnol (2010) 0.77
An in silico erythropoiesis model rationalizing synergism between stem cell factor and erythropoietin. Bioprocess Biosyst Eng (2013) 0.77
Perspectives in regenerative medicine and tissue engineering of bone. Br J Oral Maxillofac Surg (2010) 0.76
A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia. IEEE Trans Biomed Eng (2016) 0.76
Osteoinduction: translating preclinical promise into clinical reality. Br J Oral Maxillofac Surg (2010) 0.76
Free energy predictions of ligand binding to an α-helix using steered molecular dynamics and umbrella sampling simulations. J Chem Inf Model (2014) 0.76
Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed-batch bioreactors. Biotechnol J (2015) 0.76
A novel perfused rotary bioreactor for cardiomyogenesis of embryonic stem cells. Biotechnol Lett (2014) 0.76
Prostaglandin E(2) receptors as potential bone anabolic targets - selective EP4 receptor agonists. Curr Mol Pharmacol (2012) 0.76
Evaluating regulatory elements of human cytomegalovirus major immediate early gene for enhancing transgene expression levels in CHO K1 and HEK293 cells. J Biotechnol (2010) 0.76
In vitro direct osteogenesis of murine embryonic stem cells without embryoid body formation. Stem Cells Dev (2008) 0.76
The potential adverse effects of aromatase inhibitors on wound healing: in vitro and in vivo evidence. Expert Opin Drug Saf (2009) 0.76
Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. DNA Seq (2002) 0.75
Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor. Biotechnol Bioeng (2011) 0.75
Biocompatible ion selective electrode for monitoring metabolic activity during the growth and cultivation of human cells. Biosens Bioelectron (2008) 0.75
Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures. Bioprocess Biosyst Eng (2015) 0.75