Published in Biotechnol Appl Biochem on April 07, 2010
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Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab Eng (2013) 0.83
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Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture. PLoS One (2014) 0.80
Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell lines. PLoS One (2012) 0.78
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Microarray platform affords improved product analysis in mammalian cell growth studies. Biotechnol J (2013) 0.76
The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis. BMC Biotechnol (2014) 0.76
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Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing. Anal Bioanal Chem (2016) 0.75
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Metabolic engineering of CHO cells for the development of a robust protein production platform. PLoS One (2017) 0.75
High-yield production of "difficult-to-express" proteins in a continuous exchange cell-free system based on CHO cell lysates. Sci Rep (2017) 0.75
Improvements in protein production in mammalian cells from targeted metabolic engineering. Curr Opin Syst Biol (2017) 0.75
Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate Metabolism. Front Pharmacol (2017) 0.75
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46
A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? Biotechnol Bioeng (2009) 1.45
Mechanisms of protein stabilization and prevention of protein aggregation by glycerol. Biochemistry (2009) 1.28
Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng (2012) 1.17
FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling. J Cell Physiol (2010) 1.14
Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling. Biotechnol Bioeng (2004) 1.09
Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res (2010) 1.06
Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells. Mol Biotechnol (2006) 1.05
A detailed understanding of the enhanced hypothermic productivity of interferon-gamma by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.98
IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines. J Biotechnol (2011) 0.97
Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng (2008) 0.94
Application of destabilizing sequences on selection marker for improved recombinant protein productivity in CHO-DG44. Metab Eng (2007) 0.92
DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines. J Biotechnol (2010) 0.92
High-density transient gene expression in suspension-adapted 293 EBNA1 cells. Biotechnol Bioeng (2008) 0.89
Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture. Rapid Commun Mass Spectrom (2009) 0.89
Zinc as an insulin replacement in hybridoma cultures. Biotechnol Bioeng (2006) 0.89
Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production. Biotechnol Prog (2003) 0.88
An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding. Biotechnol Bioeng (2010) 0.88
Evaluation of insulin-mimetic trace metals as insulin replacements in mammalian cell cultures. Cytotechnology (2004) 0.88
Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnol Bioeng (2009) 0.86
Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production. J Biotechnol (2009) 0.86
Meeting report: second Singapore biologics manufacturing conference. Biotechnol J (2007) 0.86
Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells. Biotechnol Prog (2010) 0.86
Active hypothermic growth: a novel means for increasing total interferon-gamma production by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.84
Vector fragmentation: characterizing vector integrity in transfected clones by Southern blotting. Biotechnol Prog (2010) 0.84
Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells. Protein Expr Purif (2010) 0.83
Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinese-hamster ovary cells. Biotechnol Appl Biochem (2008) 0.83
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. J Biotechnol (2010) 0.83
Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures. Biotechnol Bioeng (2006) 0.80
Enhancement of transient gene expression by fed-batch culture of HEK 293 EBNA1 cells in suspension. Biotechnol Lett (2006) 0.80
2-D DIGE to expedite downstream process development for human monoclonal antibody purification. Protein Expr Purif (2009) 0.80
Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells. Stem Cell Res (2009) 0.79
Molecular anatomy of preferential interaction coefficients by elucidating protein solvation in mixed solvents: methodology and application for lysozyme in aqueous glycerol. J Phys Chem B (2009) 0.79
Translatome analysis of CHO cells to identify key growth genes. J Biotechnol (2013) 0.79
Identification of cellular genes critical to recombinant protein production using a Gaussia luciferase-based siRNA screening system. J Biotechnol (2010) 0.79
Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures. Metab Eng (2006) 0.79
Post-transcriptional regulatory elements for enhancing transient gene expression levels in mammalian cells. Methods Mol Biol (2012) 0.79
Modeling amino acid metabolism in mammalian cells-toward the development of a model library. Biotechnol Prog (2007) 0.79
Two-dimensional fluorescence difference gel electrophoresis for comparison of affinity and non-affinity based downstream processing of recombinant monoclonal antibody. J Chromatogr A (2009) 0.78
Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells. Biotechnol Bioeng (2006) 0.78
Rapid characterization of protein productivity and production stability of CHO cells by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom (2011) 0.78
Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. Biotechnol Prog (2009) 0.77
Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media. J Biotechnol (2010) 0.77
Rapid characterization of high/low producer CHO cells using matrix-assisted laser desorption/ionization time-of-flight. Rapid Commun Mass Spectrom (2010) 0.76
The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells. J Biotechnol (2008) 0.76
Evaluating regulatory elements of human cytomegalovirus major immediate early gene for enhancing transgene expression levels in CHO K1 and HEK293 cells. J Biotechnol (2010) 0.76
Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed-batch bioreactors. Biotechnol J (2015) 0.76
Adaptation of hybridomas to protein-free media results in a simplified two-step immunoglobulin M purification process. J Chromatogr A (2008) 0.75
Simultaneous targeting of Requiem & Alg-2 in Chinese hamster ovary cells for improved recombinant protein production. Mol Biotechnol (2010) 0.75
Elucidating the role of requiem in the growth and death of Chinese hamster ovary cells. Apoptosis (2010) 0.75
Elevation of gamma-glutamyltransferase activity in 293 HEK cells constitutively expressing antisense glutaminase mRNA. Metab Eng (2005) 0.75
Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody. Electrophoresis (2010) 0.75