Published in PLoS One on February 23, 2009
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07
Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat Rev Immunol (2009) 3.51
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J Exp Med (2010) 1.42
Gut microbiome and anticancer immune response: really hot Sh*t! Cell Death Differ (2014) 0.90
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One (2011) 0.88
NOD-like receptors in intestinal homeostasis and epithelial tissue repair. Int J Mol Sci (2014) 0.82
TAK1 regulates Paneth cell integrity partly through blocking necroptosis. Cell Death Dis (2016) 0.79
Inflammatory bowel disease: recent advances on genetics and innate immunity. Ann Gastroenterol (2011) 0.79
A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis. J Biol Chem (2015) 0.79
Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol (2017) 0.77
Inducible HSP70 antagonizes IL-1β cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 in HeLa cells. PLoS One (2012) 0.76
Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease. Physiol Rep (2017) 0.75
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PLoS One (2013) 0.75
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83
Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35
The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol (2003) 8.28
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun (1998) 7.86
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31
Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 7.17
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci (1994) 4.38
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med (2002) 4.28
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature (1999) 4.01
Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med (2006) 3.12
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem (1999) 2.40
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J Clin Invest (2000) 2.27
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection. Am J Physiol Cell Physiol (2000) 2.21
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A (2006) 2.19
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol (2006) 1.70
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
Nuclear factor kappaB subunits induce epithelial cell growth arrest. Cancer Res (2000) 1.32
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
Regulation of Nod1-mediated signaling pathways. Cell Death Differ (2006) 1.15
Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11
Transcription factor NF-kappaB participates in regulation of epithelial cell turnover in the colon. Am J Physiol Gastrointest Liver Physiol (2000) 1.10
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene (2005) 1.04
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS One (2007) 0.89
Intestinal inflammation targets cancer-inducing activity of the microbiota. Science (2012) 7.54
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol (2003) 3.17
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (2010) 2.99
The microbiome and cancer. Nat Rev Cancer (2013) 2.86
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J (2003) 2.69
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One (2010) 2.60
Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. Science (2011) 2.59
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 2.47
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep (2001) 2.22
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol (2003) 2.03
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res (2005) 2.02
Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci (2002) 1.95
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol (2004) 1.84
Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol (2007) 1.82
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol (2006) 1.70
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol (2003) 1.61
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood (2004) 1.58
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis (2007) 1.55
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. J Biol Chem (2002) 1.48
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev (2002) 1.46
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep (2004) 1.42
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem (2005) 1.41
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Gastroenterology (2011) 1.39
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem (2006) 1.37
NF-kappaB and the intestine: friend or foe? Inflamm Bowel Dis (2008) 1.33
Think small: zebrafish as a model system of human pathology. J Biomed Biotechnol (2012) 1.30
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol (2007) 1.22
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model. ISME J (2013) 1.21
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. PLoS One (2012) 1.19
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis (2011) 1.16
The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis (2011) 1.15
Inhibition of autophagy by TAB2 and TAB3. EMBO J (2011) 1.15
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology (2009) 1.15
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. J Biol Chem (2008) 1.13
Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett (2011) 1.12
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem (2006) 1.11
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour? J Pediatr Gastroenterol Nutr (2004) 1.10
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology (2005) 1.10
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells (2005) 1.07
TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol (2014) 1.07
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One (2009) 1.07
TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol (2010) 1.07
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. PLoS One (2012) 1.06
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer. Mol Pharmacol (2008) 1.06
Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells. Eur J Immunol (2005) 1.06
TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J Biol Chem (2008) 1.06
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). J Biol Chem (2003) 1.05
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem (2008) 1.04
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene (2005) 1.04
Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. Endocrinology (2005) 1.02
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation. Sci Rep (2013) 1.02
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol (2004) 1.02
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. PLoS One (2009) 1.02
Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA. Infect Immun (2007) 1.01
Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo. Am J Pathol (2005) 1.00
Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling. Gastroenterology (2011) 0.98
The complex interplay between inflammation, the microbiota and colorectal cancer. Gut Microbes (2013) 0.98
Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis (2013) 0.97
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity (2012) 0.97
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling. Am J Pathol (2011) 0.96
PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PLoS One (2011) 0.96
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta. Biochem Biophys Res Commun (2003) 0.95
Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species. Proc Natl Acad Sci U S A (2012) 0.95
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol (2014) 0.95
Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol (2013) 0.94
Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol (2011) 0.93
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood (2012) 0.93
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock (2011) 0.93
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res (2010) 0.93
Generation of a conditional mutant allele for Tab1 in mouse. Genesis (2008) 0.93
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One (2012) 0.92
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem (2006) 0.92
Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes. J Cell Physiol (2006) 0.91
Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells. J Biol Chem (2004) 0.91
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells. Cell Signal (2004) 0.91
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. Dis Model Mech (2012) 0.91
Diet, microbiome, and the intestinal epithelium: an essential triumvirate? Biomed Res Int (2013) 0.91
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. PLoS One (2007) 0.89