Critical molecular pathways in cancer stem cells of chronic myeloid leukemia.

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Published in Leukemia on June 24, 2010

Authors

Y Chen1, C Peng, C Sullivan, D Li, S Li

Author Affiliations

1: Department of Medicine, Division of Hematology/Oncology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature (2007) 10.98

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59

Cancer stem cells. N Engl J Med (2006) 9.63

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J (1998) 7.59

FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene (2005) 7.50

Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood (2002) 6.64

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94

Leukotrienes. N Engl J Med (2007) 5.00

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Lipid signalling in disease. Nat Rev Mol Cell Biol (2008) 4.85

The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem (1999) 4.62

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood (2006) 4.41

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