Published in Nature on April 09, 2009
The increasing complexity of the cancer stem cell paradigm. Science (2009) 5.45
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med (2012) 4.19
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res (2011) 4.05
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell (2010) 3.46
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature (2010) 3.12
Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell (2011) 2.80
Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med (2013) 2.55
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res (2010) 2.50
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
Cell cycle regulation in hematopoietic stem cells. J Cell Biol (2011) 2.48
Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest (2010) 2.44
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A (2009) 2.43
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
Pushing the limits of targeted therapy in chronic myeloid leukaemia. Nat Rev Cancer (2012) 2.35
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med (2010) 2.23
Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood (2011) 2.22
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A (2011) 2.08
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol (2010) 2.05
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00
Apoptosis, stem cells, and tissue regeneration. Sci Signal (2010) 1.95
ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal (2010) 1.91
Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell (2009) 1.84
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood (2011) 1.76
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance. Blood (2014) 1.61
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell (2009) 1.61
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell (2013) 1.59
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res (2010) 1.57
Imatinib and beyond--exploring the full potential of targeted therapy for CML. Nat Rev Clin Oncol (2009) 1.51
Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol (2012) 1.50
Genetic and biochemical definition of the Hedgehog receptor. Genes Dev (2010) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med (2011) 1.45
Concise review: Emerging concepts in clinical targeting of cancer stem cells. Stem Cells (2011) 1.45
Identification and targeting of cancer stem cells. Bioessays (2009) 1.44
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res (2012) 1.39
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells. J Cell Mol Med (2013) 1.38
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood (2010) 1.37
Targeting the Hedgehog pathway in cancer. Ther Adv Med Oncol (2010) 1.35
Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol (2012) 1.34
Up-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cells. PLoS One (2011) 1.30
Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One (2011) 1.30
Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy. Oncotarget (2011) 1.27
Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco Targets Ther (2012) 1.27
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med (2012) 1.27
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood (2012) 1.26
Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res (2012) 1.26
Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am J Pathol (2011) 1.18
Self-renewal related signaling in myeloid leukemia stem cells. Int J Hematol (2011) 1.17
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Expression patterns of microRNAs associated with CML phases and their disease related targets. Mol Cancer (2011) 1.12
Targeting cancer stem cells: a new therapy to cure cancer patients. Am J Cancer Res (2012) 1.11
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein. J Biol Chem (2011) 1.10
The bone marrow microenvironment as niche retreats for hematopoietic and leukemic stem cells. Adv Hematol (2013) 1.09
CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood (2014) 1.09
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell (2013) 1.08
Breast cancer stem cells: Multiple capacities in tumor metastasis. Cancer Lett (2014) 1.07
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. Blood (2012) 1.07
Smoothened as a new therapeutic target for human osteosarcoma. Mol Cancer (2010) 1.06
Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One (2010) 1.06
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. Blood (2014) 1.04
Targeting survival pathways in chronic myeloid leukaemia stem cells. Br J Pharmacol (2013) 1.04
Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells (2010) 1.03
Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis. Mol Cancer Ther (2013) 1.02
Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J (2014) 1.01
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res (2009) 1.01
The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy. Breast Cancer Res (2013) 1.01
BCR-ABL kinase is dead; long live the CML stem cell. J Clin Invest (2010) 1.00
Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res (2011) 1.00
An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development. PLoS Genet (2013) 1.00
Targeting hedgehog signaling in cancer: research and clinical developments. Onco Targets Ther (2013) 0.99
Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions. J Biol Chem (2011) 0.98
ABC transporters in CSCs membranes as a novel target for treating tumor relapse. Front Pharmacol (2014) 0.98
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet (2012) 0.97
Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells. Oncotarget (2016) 0.97
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res (2015) 0.96
NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biol Blood Marrow Transplant (2010) 0.95
Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer. Cancer Sci (2014) 0.95
Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development. PLoS Pathog (2010) 0.95
Cooperative Hedgehog-EGFR signaling. Front Biosci (Landmark Ed) (2012) 0.95
CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Clin Cancer Res (2014) 0.95
Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Stem Cells (2012) 0.95
Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia (2010) 0.95
The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis. Leukemia (2011) 0.94
The utility of hedgehog signaling pathway inhibition for cancer. Oncologist (2012) 0.94
Hedgehog signaling: networking to nurture a promalignant tumor microenvironment. Mol Cancer Res (2011) 0.94
Hedgehog signaling in cancer stem cells: a focus on hematological cancers. Stem Cells Cloning (2015) 0.93
β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci U S A (2012) 0.93
Emerging therapeutic strategies for targeting chronic myeloid leukemia stem cells. Stem Cells Int (2013) 0.93
Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies. Oncogene (2015) 0.92
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers (Basel) (2016) 0.91
Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways. Acta Pharmacol Sin (2013) 0.91
Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies. J Hematol Oncol (2014) 0.91
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (2001) 20.30
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
The Hedgehog and Wnt signalling pathways in cancer. Nature (2001) 9.19
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood (2002) 6.64
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer (2005) 4.30
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell (2007) 4.21
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol (2001) 3.97
Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A (2006) 3.48
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci (2008) 3.46
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood (2007) 2.68
Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med (2007) 2.62
Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci (2007) 2.56
Comment on "Tumor growth need not be driven by rare cancer stem cells". Science (2007) 2.41
Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat Rev Genet (2006) 2.26
The hedgehog signaling pathway in cancer. Clin Cancer Res (2006) 2.15
Targeted CML therapy: controlling drug resistance, seeking cure. Curr Opin Genet Dev (2005) 2.08
Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol (2005) 6.49
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest (2005) 5.30
The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell (2007) 4.21
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62
Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature (2010) 3.20
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature (2011) 3.15
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A (2009) 2.43
Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med (2007) 2.38
Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening. J Immunol Methods (2004) 1.96
Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med (2013) 1.95
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med (2010) 1.94
Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. Am J Clin Pathol (2011) 1.91
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol (2014) 1.86
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev (2012) 1.84
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem (2007) 1.83
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest (2013) 1.65
Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. Lancet Oncol (2012) 1.59
Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial. J Clin Oncol (2012) 1.58
Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell (2010) 1.57
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. Clin Cancer Res (2013) 1.53
Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood (2009) 1.52
Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia. Leuk Lymphoma (2011) 1.51
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol (2004) 1.50
Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia. J Clin Oncol (2006) 1.48
Genetic and biochemical definition of the Hedgehog receptor. Genes Dev (2010) 1.47
Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One (2008) 1.44
Phase II multicenter study of arsenic trioxide in patients with myelodysplastic syndromes. J Clin Oncol (2006) 1.42
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A (2005) 1.40
Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant (2003) 1.37
Identification of adiponectin as a novel hemopoietic stem cell growth factor. J Immunol (2007) 1.32
Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol (2008) 1.32
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem (2005) 1.28
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1. Cancer Res (2007) 1.21
Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci U S A (2010) 1.21
Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant (2012) 1.20
Activation of Wnt signaling in hematopoietic regeneration. Stem Cells (2008) 1.18
Frizzled 9 knock-out mice have abnormal B-cell development. Blood (2004) 1.16
Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest (2014) 1.16
Wnt signaling in the stem cell niche. Curr Opin Hematol (2004) 1.15
Myeloablative intravenous busulfan/fludarabine conditioning does not facilitate reliable engraftment of dual umbilical cord blood grafts in adult recipients. Biol Blood Marrow Transplant (2008) 1.15
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell (2013) 1.15
Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol (2013) 1.14
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One (2010) 1.13
Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep (2012) 1.08
Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One (2010) 1.07
Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer. Bioorg Med Chem (2008) 1.06
Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol (2006) 1.06
Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia. Leuk Lymphoma (2008) 1.04
Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. Biol Blood Marrow Transplant (2010) 1.02
Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat. J Virol (2003) 1.02
Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. Hum Genet (2009) 1.01
Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res (2010) 1.01
Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord (2010) 1.01
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A (2011) 1.00
Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology (Berl) (2011) 1.00
Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting. Sarcoma (2012) 0.99
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity. Clin Cancer Res (2010) 0.98