Published in Autophagy on July 04, 2007
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The BCL-2 family reunion. Mol Cell (2010) 7.32
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A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ (2010) 2.25
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Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res (2009) 1.88
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DNA damage and autophagy. Mutat Res (2011) 1.34
Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell (2010) 1.32
Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32
The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. J Virol (2011) 1.31
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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak. Proc Natl Acad Sci U S A (2014) 1.14
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Obatoclax and lapatinib interact to induce toxic autophagy through NOXA. Mol Pharmacol (2012) 1.10
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Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PLoS One (2010) 1.06
Autophagic pathways as new targets for cancer drug development. Acta Pharmacol Sin (2010) 1.05
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis (2013) 1.03
Tumor suppression and promotion by autophagy. Biomed Res Int (2014) 1.02
Functions of BCL-X L at the Interface between Cell Death and Metabolism. Int J Cell Biol (2013) 1.02
Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer (2013) 0.99
Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLoS One (2013) 0.98
The development of MDA-7/IL-24 as a cancer therapeutic. Pharmacol Ther (2010) 0.98
RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One (2011) 0.98
Regulation of the autophagic bcl-2/beclin 1 interaction. Cells (2012) 0.98
A1/Bfl-1 in leukocyte development and cell death. Exp Cell Res (2012) 0.97
The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev (2012) 0.95
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer (2009) 0.94
p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome. J Biol Chem (2013) 0.93
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis (2013) 0.93
MAPK/JNK signalling: a potential autophagy regulation pathway. Biosci Rep (2015) 0.93
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy (2014) 0.92
Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci (2013) 0.91
Targeting autophagic pathways for cancer drug discovery. Chin J Cancer (2012) 0.91
The family that eats together stays together: new p53 family transcriptional targets in autophagy. Genes Dev (2013) 0.89
PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy (2015) 0.88
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy (2012) 0.86
DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy (2014) 0.86
The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol (2014) 0.85
Autophagy and mitophagy in the myocardium: therapeutic potential and concerns. Br J Pharmacol (2014) 0.84
Autophagy in the light of sphingolipid metabolism. Apoptosis (2015) 0.84
Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses. Reprod Sci (2014) 0.83
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. J Mol Signal (2012) 0.83
The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin (2015) 0.83
Nigericin-induced impairment of autophagic flux in neuronal cells is inhibited by overexpression of Bak. J Biol Chem (2012) 0.82
Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases. Int J Mol Sci (2016) 0.82
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway. Mol Med Rep (2015) 0.81
Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury. J Neurotrauma (2015) 0.81
Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage. Mol Oncol (2014) 0.81
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes. Biochim Biophys Acta (2012) 0.80
Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy. Biochemistry (2016) 0.80
Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond. Protein Sci (2016) 0.80
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem (2014) 0.79
The BECN1 N-terminal domain is intrinsically disordered. Autophagy (2016) 0.79
The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. Cell Mol Neurobiol (2014) 0.79
Autophagy in Chronic Kidney Diseases. Kidney Dis (Basel) (2016) 0.79
Who put the "A" in Atg12: autophagy or apoptosis? Mol Cell (2011) 0.79
RNA-dependent protein kinase is essential for 2-methoxyestradiol-induced autophagy in osteosarcoma cells. PLoS One (2013) 0.79
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. BMC Cancer (2015) 0.79
Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions. Respir Res (2015) 0.78
The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases. Oncotarget (2016) 0.78
The interplay of reovirus with autophagy. Biomed Res Int (2014) 0.78
Effect of limb ischemic preconditioning on myocardial apoptosis-related proteins in ischemia-reperfusion injury. Exp Ther Med (2013) 0.78
The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer. Oncotarget (2016) 0.78
Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells. Biomol Ther (Seoul) (2012) 0.78
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
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Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
The hallmarks of aging. Cell (2013) 14.29
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
The pathophysiology of mitochondrial cell death. Science (2004) 13.87
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61
Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13
Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Autophagy and aging. Cell (2011) 5.96
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75
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The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
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An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32
Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07
The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64
The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60
Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41
Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41
Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26
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A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21
AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96
Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Platelet formation is the consequence of caspase activation within megakaryocytes. Blood (2002) 2.62
Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56
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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47
The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41
Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33
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Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32
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miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
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Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14
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Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells. Cell Cycle (2010) 2.08
Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05
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