p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals.

Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype. J Biol Chem (2011) 1.15

Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation. Sci Rep (2012) 1.11

The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation. J Biol Chem (2011) 1.11

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10

Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix. Clin Epigenetics (2012) 1.06

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06

Scratching the (lateral) surface of chromatin regulation by histone modifications. Nat Struct Mol Biol (2013) 1.05

Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. Am J Physiol Lung Cell Mol Physiol (2012) 1.04

Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Cell Cycle (2012) 1.03

Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Mol Med (2011) 1.03

Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01

ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation. Nucleic Acids Res (2011) 0.98

Histone H3 lysine 56 acetylation and the response to DNA replication fork damage. Mol Cell Biol (2011) 0.97

Epigenetic regulation of genomic integrity. Chromosoma (2012) 0.93

The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (2013) 0.92

Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91

CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes. PLoS One (2011) 0.88

Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun (2016) 0.86

Oncogene Ras/phosphatidylinositol 3-kinase signaling targets histone H3 acetylation at lysine 56. J Biol Chem (2012) 0.85

Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes. Biosci Rep (2013) 0.85

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. PLoS One (2013) 0.85

Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. J Biol Chem (2012) 0.84

DNA damage due to oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). Int J Mol Sci (2012) 0.83

Cracking the survival code: autophagy-related histone modifications. Autophagy (2014) 0.83

Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines. Radiat Oncol (2014) 0.83

Double-strand breaks and the concept of short- and long-term epigenetic memory. Chromosoma (2010) 0.82

Metformin targets histone acetylation in cancer-prone epithelial cells. Cell Cycle (2016) 0.81

Acetylation of Chromatin-Associated Histone H3 Lysine 56 Inhibits the Development of Encysted Artemia Embryos. PLoS One (2013) 0.81

Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations. Environ Mol Mutagen (2013) 0.81

Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. Nucleic Acids Res (2015) 0.80

'Relax and Repair' to restrain aging. Aging (Albany NY) (2011) 0.80

Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects. Front Oncol (2012) 0.79

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells. J Virol (2013) 0.79

The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines. Adv Biomed Res (2013) 0.79

Facilitation of base excision repair by chromatin remodeling. DNA Repair (Amst) (2015) 0.78

Site-specific Acetylation of Histone H3 Decreases Polymerase β Activity on Nucleosome Core Particles in Vitro. J Biol Chem (2016) 0.78

Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. J Biol Chem (2015) 0.77

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses. Mol Biol Cell (2016) 0.77

Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction. J Phys Chem B (2014) 0.77

p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell Dev Biol (2013) 0.76

Aberrant levels of histone H3 acetylation induce spermatid anomaly in mouse testis. Histochem Cell Biol (2014) 0.76

Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. Int J Prev Med (2013) 0.76

Targeting chromatin to improve radiation response. Br J Radiol (2014) 0.76

Cell cycle-dependent changes in H3K56ac in human cells. Cell Cycle (2015) 0.76

Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes. PLoS One (2016) 0.76

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell (2017) 0.75

Protein kinase C coordinates histone H3 phosphorylation and acetylation. Elife (2015) 0.75

The Commercial Antibodies Widely Used to Measure H3 K56 Acetylation Are Non-Specific in Human and Drosophila Cells. PLoS One (2016) 0.75

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. Sci Rep (2016) 0.75

Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats. Cell Death Dis (2017) 0.75

Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft. Invest New Drugs (2017) 0.75

Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis (2017) 0.75

Chromatin modifications and their function. Cell (2007) 55.98

The language of covalent histone modifications. Nature (2000) 44.92

Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30

Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46

Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28

Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25

Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol (2003) 5.92

Histones and histone modifications. Curr Biol (2004) 5.78

Chromatin challenges during DNA replication and repair. Cell (2007) 5.23

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature (2005) 5.13

Histone acetyltransferase complexes: one size doesn't fit all. Nat Rev Mol Cell Biol (2007) 5.12

Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97

CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature (2009) 4.83

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature (2002) 4.18

Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science (2007) 4.12

Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science (2007) 4.07

Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell (2008) 3.96

Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84

Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell (2005) 3.82

Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1. Mol Cell (2007) 3.60

Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes. Mol Cell (2007) 3.38

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol (2006) 3.37

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J (2009) 2.98

The histone code at DNA breaks: a guide to repair? Nat Rev Mol Cell Biol (2005) 2.97

Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell (2006) 2.91

Chromatin dynamics and the preservation of genetic information. Nature (2007) 2.80

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol (2003) 2.79

Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle (2009) 2.77

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77

Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76

Crosstalk among Histone Modifications. Cell (2008) 2.70

Chromatin dynamics at DNA replication, transcription and repair. Eur J Biochem (2004) 2.01

Characterization of lysine 56 of histone H3 as an acetylation site in Saccharomyces cerevisiae. J Biol Chem (2005) 1.95

Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol (2008) 1.89

Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med (2004) 1.49

Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Mol Cell Biol (2005) 1.12

Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation. Eukaryot Cell (2008) 1.04

Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle (2006) 1.03

Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. Cell Mol Life Sci (2003) 1.01

Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells. Int J Oncol (2008) 0.96

pC6-2/caspase-6 system to purify glutathione-S-transferase-free recombinant fusion proteins expressed in Escherichia coli. Nat Protoc (2006) 0.86

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93

Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol (2006) 2.29

The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1. Curr Opin Genet Dev (2007) 1.75

Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biol (2010) 1.64

Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell (2006) 1.63

HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes. Nucleic Acids Res (2011) 1.25

Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition. Biol Psychiatry (2012) 1.19

Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Mol Cell Biol (2005) 1.12

Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. Mol Cell Biol (2008) 1.10

Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. Int J Cancer (2003) 1.10

STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem (2012) 1.09

Decoy-DNA against special AT-rich sequence binding protein 1 inhibits the growth and invasive ability of human breast cancer. Oligonucleotides (2011) 1.00

Chromatin organizer SATB1 as a novel molecular target for cancer therapy. Curr Drug Targets (2012) 0.98

PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Nucleic Acids Res (2008) 0.96

Studying histone modifications and their genomic functions by employing chromatin immunoprecipitation and immunoblotting. Methods Cell Biol (2010) 0.94

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. Blood (2010) 0.93

Amberlite IR-120H catalyzed MCR: design, synthesis and crystal structure analysis of 1,8-dioxodecahydroacridines as potential inhibitors of sirtuins. Bioorg Med Chem Lett (2013) 0.90

DNA damage in the presence of chemical genotoxic agents induce acetylation of H3K56 and H4K16 but not H3K9 in mammalian cells. Mol Biol Rep (2011) 0.89

Down-regulation of the global regulator SATB1 by statins in COLO205 colon cancer cells. Mol Med Rep (2010) 0.87

tRNA genes as chromatin barriers. Nat Struct Mol Biol (2006) 0.87

SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites. J Virol (2007) 0.87

pC6-2/caspase-6 system to purify glutathione-S-transferase-free recombinant fusion proteins expressed in Escherichia coli. Nat Protoc (2006) 0.86

Chromatin organizer SATB1 is an important determinant of T-cell differentiation. Immunol Cell Biol (2012) 0.84

Phosphorylation-dependent regulation of SATB1, the higher-order chromatin organizer and global gene regulator. Methods Mol Biol (2010) 0.84

N-terminal PDZ-like domain of chromatin organizer SATB1 contributes towards its function as transcription regulator. J Biosci (2011) 0.84

One size does not fit all: on how Markov model order dictates performance of genomic sequence analyses. Nucleic Acids Res (2012) 0.83

Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions. Nucleic Acids Res (2003) 0.80

Enhancer RNAs. Cell Cycle (2014) 0.79

GST fusion vector with caspase-6 cleavage site for removal of fusion tag during column purification. Biotechniques (2005) 0.77

A clickable UTP analog for the posttranscriptional chemical labeling and imaging of RNA. Org Biomol Chem (2016) 0.76

Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome. Bioessays (2005) 0.76

Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 locus. J Genet (2010) 0.76

Modulation of signal transduction pathways in lymphocytes due to sub-lethal toxicity of chlorinated phenol. Toxicol Lett (2008) 0.75

Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus. J Biosci (2015) 0.75

AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest. Chem Commun (Camb) (2013) 0.75

Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2'-quinazolines. Bioorg Med Chem Lett (2013) 0.75

Construction and functionalization of pyranone ring fused with pyran moiety: design and synthesis of novel pyrano[4,3-b]pyran-5(4H)-ones as potential inhibitors of sirtuins. Bioorg Med Chem Lett (2013) 0.75

Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest. Org Biomol Chem (2013) 0.75