Published in Nature on June 21, 2007
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol (2009) 3.50
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J (2009) 2.98
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell (2011) 2.50
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature (2013) 2.17
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04
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Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell (2008) 1.99
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J (2010) 1.86
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol (2011) 1.77
Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet (2009) 1.69
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Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
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Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol (2008) 1.50
The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene (2009) 1.45
Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. Mol Cell (2009) 1.45
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals. J Biol Chem (2010) 1.34
Histone H2A variants in nucleosomes and chromatin: more or less stable? Nucleic Acids Res (2012) 1.33
Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem (2011) 1.29
Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A (2009) 1.25
Molecular basis of histone H3K4me3 recognition by ING4. J Biol Chem (2008) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
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Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance. DNA Repair (Amst) (2009) 1.21
Evidence that nucleosomes inhibit mismatch repair in eukaryotic cells. J Biol Chem (2009) 1.20
The many faces of ubiquitinated histone H2A: insights from the DUBs. Cell Div (2008) 1.18
Postradiation sensitization of the histone deacetylase inhibitor valproic acid. Clin Cancer Res (2008) 1.12
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Sci Signal (2011) 1.11
Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage. J Biol Chem (2008) 1.09
The histone variant H2A.W defines heterochromatin and promotes chromatin condensation in Arabidopsis. Cell (2014) 1.08
Nucleosome remodeling and epigenetics. Cold Spring Harb Perspect Biol (2013) 1.07
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae. Genetics (2009) 1.06
Chromatin dynamics during repair of chromosomal DNA double-strand breaks. Epigenomics (2009) 1.05
The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell (2014) 1.04
The AID-induced DNA damage response in chromatin. Mol Cell (2013) 1.04
RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol Cell Biol (2011) 0.99
MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol (2008) 0.99
CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now. Biochem Soc Trans (2013) 0.98
HMGNs, DNA repair and cancer. Biochim Biophys Acta (2009) 0.98
Non-coding RNAs in DNA damage and repair. FEBS Lett (2013) 0.97
Role for hACF1 in the G2/M damage checkpoint. Nucleic Acids Res (2011) 0.97
Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. J Cell Biol (2009) 0.97
Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1. Genetics (2008) 0.96
The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni. PLoS One (2009) 0.95
Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem (2012) 0.94
Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors. EMBO J (2008) 0.93
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus. Proc Natl Acad Sci U S A (2008) 0.93
Fine tuning gene expression: the epigenome. Semin Nephrol (2010) 0.93
An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis. Development (2012) 0.91
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage. J Cell Biol (2008) 0.90
Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J Biol Chem (2013) 0.89
Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. Nucleic Acids Res (2012) 0.89
The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair. J Cell Biol (2010) 0.89
Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFβ receptor pathways controlling mitosis and eggshell formation. PLoS Pathog (2013) 0.89
HERC2-USP20 axis regulates DNA damage checkpoint through Claspin. Nucleic Acids Res (2014) 0.88
Histone h3 glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure. Antioxid Redox Signal (2013) 0.87
A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana. PLoS Genet (2009) 0.87
Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression. J Virol (2014) 0.87
Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation. Mol Cell Biol (2010) 0.86
Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis. PLoS One (2012) 0.84
Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells. J Biol Chem (2014) 0.83
UV sensitive mutations in histone H3 in Saccharomyces cerevisiae that alter specific K79 methylation states genetically act through distinct DNA repair pathways. Curr Genet (2008) 0.83
Chromatin remodeling, DNA damage repair and aging. Curr Genomics (2012) 0.82
Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks. Genome Integr (2011) 0.82
Nucleosome binding proteins potentiate ATM activation and DNA damage response by modifying chromatin. Cell Cycle (2009) 0.82
Histone H2AX suppresses translocations in lymphomas of Eμ-c-Myc transgenic mice that contain a germline amplicon of tumor-promoting genes. Cell Cycle (2013) 0.81
CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells. Epigenetics Chromatin (2015) 0.81
Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma. Blood (2010) 0.80
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. Biomed Res Int (2014) 0.80
Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes. J Immunol (2012) 0.80
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol (2014) 0.79
Connecting chromatin modifying factors to DNA damage response. Int J Mol Sci (2013) 0.79
DNA double-strand breaks: linking gene expression to chromosome morphology and mobility. Chromosoma (2013) 0.78
Analysis of chromatin remodeling during formation of a DNA double-strand break at the yeast mating type locus. Methods (2009) 0.78
Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts. Epigenetics (2013) 0.78
Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome Integr (2012) 0.77
A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe. Yeast (2012) 0.77
Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage. J Biol Chem (2014) 0.76
Solution structure of the isolated histone H2A-H2B heterodimer. Sci Rep (2016) 0.75
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination. Genes Dev (2016) 0.75
Repair of DNA Double-Strand Breaks in Heterochromatin. Biomolecules (2016) 0.75
Genetic compensation: A phenomenon in search of mechanisms. PLoS Genet (2017) 0.75
Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation. Oncotarget (2017) 0.75
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Predominant autoantibody production by early human B cell precursors. Science (2003) 13.14
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (2011) 9.00
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42
Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13
H2AX: the histone guardian of the genome. DNA Repair (Amst) (2004) 6.65
Germinal centers. Annu Rev Immunol (2012) 6.26
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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods (2007) 5.97
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science (2011) 4.30
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med (2005) 4.16
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature (2013) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83
Autoreactivity in human IgG+ memory B cells. Immunity (2007) 3.71
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A (2012) 3.33
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature (2006) 3.31
Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31
A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature (2013) 3.14
Antibodies in HIV-1 vaccine development and therapy. Science (2013) 3.13
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Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell (2013) 3.04
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A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 2.82
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science (2002) 2.75
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69
Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol (2002) 2.64
Role of BCR affinity in T cell dependent antibody responses in vivo. Nat Immunol (2002) 2.63
A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med (2006) 2.60
A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods (2008) 2.56
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Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55
Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med (2006) 2.53
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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell (2003) 2.50
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46
Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase. Annu Rev Pathol (2012) 2.45
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
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Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 2.43
ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30
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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature (2007) 2.30
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell (2012) 2.21
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci U S A (2008) 2.18
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Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein. J Exp Med (2012) 2.12
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. J Exp Med (2003) 2.09
Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (2003) 2.06
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A (2007) 2.04