Published in Nature on February 10, 2011
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
Linking disease associations with regulatory information in the human genome. Genome Res (2012) 5.47
Atherosclerosis: current pathogenesis and therapeutic options. Nat Med (2011) 4.95
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat Genet (2011) 2.42
Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum Mol Genet (2011) 2.21
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Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet (2012) 2.00
HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter. Genome Res (2012) 1.96
Molecular genetic studies of complex phenotypes. Transl Res (2011) 1.95
Genetics of human cardiovascular disease. Cell (2012) 1.90
Enhancer RNAs and regulated transcriptional programs. Trends Biochem Sci (2014) 1.85
High-throughput sequencing for biology and medicine. Mol Syst Biol (2013) 1.75
Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet (2012) 1.72
Genomic approaches towards finding cis-regulatory modules in animals. Nat Rev Genet (2012) 1.65
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation (2012) 1.60
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet (2011) 1.60
Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets. Nat Rev Cardiol (2011) 1.57
Transcriptional enhancers in development and disease. Genome Biol (2012) 1.52
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50
Enhancers: five essential questions. Nat Rev Genet (2013) 1.46
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Heart Rhythm (2012) 1.43
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell (2012) 1.36
Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Res (2012) 1.35
Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genet (2013) 1.34
Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum Mol Genet (2012) 1.34
Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Proc Natl Acad Sci U S A (2012) 1.34
Strategic approaches to unraveling genetic causes of cardiovascular diseases. Circ Res (2011) 1.31
Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model. Nat Genet (2013) 1.30
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet (2011) 1.29
11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat (2012) 1.26
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet (2011) 1.26
Uncovering the role of genomic "dark matter" in human disease. J Clin Invest (2012) 1.26
A role for noncoding variation in schizophrenia. Cell Rep (2014) 1.26
Systematic functional regulatory assessment of disease-associated variants. Proc Natl Acad Sci U S A (2013) 1.22
Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol (2013) 1.19
Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. Arterioscler Thromb Vasc Biol (2011) 1.16
Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies. J Biol Chem (2012) 1.15
Genetic basis of atherosclerosis: insights from mice and humans. Circ Res (2012) 1.14
Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J (2013) 1.14
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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol (2013) 1.12
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol (2012) 1.12
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res (2013) 1.10
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS One (2012) 1.10
Ink4-Arf locus in cancer and aging. Wiley Interdiscip Rev Dev Biol (2013) 1.09
The chromatin fingerprint of gene enhancer elements. J Biol Chem (2012) 1.08
ANRIL: molecular mechanisms and implications in human health. Int J Mol Sci (2013) 1.07
Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays (2013) 1.06
Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. Circ Cardiovasc Genet (2011) 1.05
Type 2 diabetes and obesity: genomics and the clinic. Hum Genet (2011) 1.04
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Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. J Am Soc Nephrol (2014) 1.01
Sex differences in disease risk from reported genome-wide association study findings. Hum Genet (2011) 1.01
Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases. Curr Opin Genet Dev (2013) 1.01
Network medicine approaches to the genetics of complex diseases. Discov Med (2012) 1.00
Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations. Genome Biol (2016) 1.00
Epigenetic regulation in human melanoma: past and future. Epigenetics (2015) 0.98
Genetics of atherosclerosis. Trends Genet (2012) 0.97
Higher-order chromatin domains link eQTLs with the expression of far-away genes. Nucleic Acids Res (2013) 0.97
Cardiovascular risk. Br J Clin Pharmacol (2012) 0.97
Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics (2011) 0.95
Enhancer variants: evaluating functions in common disease. Genome Med (2014) 0.95
Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics. Clin Chem (2011) 0.95
Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke. Stroke (2014) 0.95
Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study. BMC Med Genet (2013) 0.95
Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux. Front Genet (2012) 0.95
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding. PLoS Genet (2015) 0.94
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet (2013) 0.93
Dissecting the causal genetic mechanisms of coronary heart disease. Curr Atheroscler Rep (2014) 0.93
Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts. Am J Hum Genet (2012) 0.93
From genotype to phenotype in human atherosclerosis--recent findings. Curr Opin Lipidol (2013) 0.93
Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease. Diabetologia (2011) 0.93
Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies. Hum Mutat (2013) 0.92
Common genetic variants in the 9p21 region and their associations with multiple tumours. Br J Cancer (2013) 0.92
Functional anatomy of distant-acting mammalian enhancers. Philos Trans R Soc Lond B Biol Sci (2013) 0.91
The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS One (2012) 0.91
The enigma of genetics etiology of atherosclerosis in the post-GWAS era. Curr Atheroscler Rep (2012) 0.91
Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway. RNA Biol (2016) 0.91
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Hunting human disease genes: lessons from the past, challenges for the future. Hum Genet (2013) 0.90
Insights into the genetic basis of type 2 diabetes. J Diabetes Investig (2013) 0.90
Genome-wide association studies of late-onset cardiovascular disease. J Mol Cell Cardiol (2015) 0.89
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. Int J Mol Sci (2014) 0.88
The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions. Circ Res (2015) 0.88
Genetics of coronary artery disease: an update. Methodist Debakey Cardiovasc J (2014) 0.87
Genetic "lnc"-age of noncoding RNAs to human disease. J Clin Invest (2012) 0.87
Molecular genetics of coronary artery disease. J Hum Genet (2015) 0.87
The multifaceted functions of CXCL10 in cardiovascular disease. Biomed Res Int (2014) 0.86
Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data. PLoS One (2013) 0.86
Genomics meets proteomics: identifying the culprits in disease. Hum Genet (2013) 0.86
Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Transl Psychiatry (2012) 0.85
TRACER: a resource to study the regulatory architecture of the mouse genome. BMC Genomics (2013) 0.85
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
The ENCODE (ENCyclopedia Of DNA Elements) Project. Science (2004) 38.24
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Capturing chromosome conformation. Science (2002) 23.93
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
Interchromosomal interactions and olfactory receptor choice. Cell (2006) 6.93
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
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Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature (2010) 3.77
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37
Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol (2009) 2.79
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One (2009) 2.77
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A (2007) 2.17
A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation (2009) 1.59
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res (2006) 1.52
Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells. J Virol (2005) 1.03
Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes. Trends Mol Med (2008) 0.95
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
A high-resolution map of active promoters in the human genome. Nature (2005) 24.35
Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22
Molecular determinants of resistance to antiandrogen therapy. Nat Med (2003) 18.90
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med (2006) 18.25
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Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A (2008) 11.86
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA (2002) 11.06
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Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet (2005) 9.61
Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol (2009) 9.59
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
A map of the cis-regulatory sequences in the mouse genome. Nature (2012) 8.74
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med (2011) 6.90
High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet (2005) 6.86
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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71
Genome-wide analysis of protein-DNA interactions. Annu Rev Genomics Hum Genet (2006) 6.47
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Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
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Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet (2005) 5.00
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80
Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nat Biotechnol (2009) 4.80
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Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
Genomewide SNP variation reveals relationships among landraces and modern varieties of rice. Proc Natl Acad Sci U S A (2009) 4.65
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature (2009) 4.61
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A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell (2004) 4.39
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 4.33
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
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Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med (2007) 4.30
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Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science (2002) 4.19
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Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell (2012) 4.00
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96