Published in Proc Natl Acad Sci U S A on July 12, 2010
Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci (2014) 1.63
The contribution of GABAergic dysfunction to neurodevelopmental disorders. Trends Mol Med (2011) 1.08
Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner. Mol Cell Neurosci (2011) 1.02
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives. Front Cell Neurosci (2014) 1.01
Abnormal relationship between GABA, neurophysiology and impulsive behavior in neurofibromatosis type 1. Cortex (2014) 0.99
Treatment of neurodevelopmental disorders in adulthood. J Neurosci (2012) 0.93
The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. Am J Med Genet A (2012) 0.91
Neurofibromatosis type 1: modeling CNS dysfunction. J Neurosci (2012) 0.89
Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1. BMC Neurol (2013) 0.89
Impairment of Procedural Learning and Motor Intracortical Inhibition in Neurofibromatosis Type 1 Patients. EBioMedicine (2015) 0.87
Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities. J Neurodev Disord (2013) 0.85
Genetic architecture of declarative memory: implications for complex illnesses. Neuroscientist (2011) 0.85
RASopathies: unraveling mechanisms with animal models. Dis Model Mech (2015) 0.84
Abnormal brain activation in neurofibromatosis type 1: a link between visual processing and the default mode network. PLoS One (2012) 0.83
Neurocognitive profiles of learning disabled children with neurofibromatosis type 1. Front Hum Neurosci (2014) 0.81
Cognitive and psychosocial phenotype of young children with neurofibromatosis-1. J Int Neuropsychol Soc (2013) 0.80
HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Mol Psychiatry (2015) 0.80
Alterations in white matter microstructure in neurofibromatosis-1. PLoS One (2012) 0.79
A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol (2016) 0.79
Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. Biol Psychiatry (2014) 0.79
Neurofibromin Loss of Function Drives Excessive Grooming in Drosophila. G3 (Bethesda) (2016) 0.77
Resting state functional MRI reveals abnormal network connectivity in neurofibromatosis 1. Hum Brain Mapp (2015) 0.77
The molecular basis of cognitive deficits in pervasive developmental disorders. Learn Mem (2012) 0.77
In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome. Front Cell Neurosci (2015) 0.76
COMT Val(158)Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1. Front Hum Neurosci (2016) 0.75
Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Nat Commun (2016) 0.75
Skeletal muscle and motor deficits in Neurofibromatosis Type 1. J Musculoskelet Neuronal Interact (2015) 0.75
GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study. Neurology (2016) 0.75
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum. Curr Biol (2016) 0.75
Emerging genotype-phenotype relationships in patients with large NF1 deletions. Hum Genet (2017) 0.75
Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition. Genes Brain Behav (2016) 0.75
Impaired synaptic plasticity in RASopathies: a mini-review. J Neural Transm (Vienna) (2016) 0.75
Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies. J Neurodev Disord (2017) 0.75
Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes. Mol Autism (2017) 0.75
Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage (2004) 49.54
Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage (2002) 38.46
A global optimisation method for robust affine registration of brain images. Med Image Anal (2001) 27.87
The NEURON simulation environment. Neural Comput (1997) 14.21
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci (2003) 10.44
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science (1990) 8.91
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol (1989) 7.86
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94
Neuron activity related to short-term memory. Science (1971) 5.76
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev (2001) 4.68
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. Nat Neurosci (2007) 3.74
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell (1990) 3.56
Do rats have a prefrontal cortex? Behav Brain Res (2003) 3.38
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05
Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay. J Neurosci (1997) 2.92
Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol (2005) 2.62
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol (2008) 2.46
Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans. Biol Psychol (2006) 2.36
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res (2003) 2.30
Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas". J Neurosci (1993) 2.30
Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory. J Neurosci (2000) 2.13
A role for inhibition in shaping the temporal flow of information in prefrontal cortex. Nat Neurosci (2002) 2.03
The nature and frequency of cognitive deficits in children with neurofibromatosis type 1. Neurology (2005) 1.98
Rodent models of prefrontal cortical function. Trends Neurosci (2002) 1.84
Fragile X: translation in action. Neuropsychopharmacology (2007) 1.65
Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex. Behav Neurosci (1995) 1.58
Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry (2005) 1.57
Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome. Biol Psychiatry (2007) 1.48
Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cereb Cortex (2002) 1.46
Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex. Neuropsychopharmacology (2004) 1.30
Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease. J Neurosci (2009) 1.28
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology (2009) 1.27
Impact of neurofibromatosis type 1 on school performance. J Child Neurol (2008) 1.27
Functional neuroanatomy of visuo-spatial working memory in Turner syndrome. Hum Brain Mapp (2001) 1.23
Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage (2002) 1.21
Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm maze. J Neurosci (1999) 1.19
Divergent plasticity of prefrontal cortex networks. Neuropsychopharmacology (2007) 1.12
Functional neuroanatomy of visuospatial working memory in fragile X syndrome: relation to behavioral and molecular measures. Am J Psychiatry (2001) 1.12
Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeys. Exp Brain Res (1989) 1.10
Frontal syndrome and disorders of executive functions. J Neurol (2003) 1.10
Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia. Arch Gen Psychiatry (2007) 1.08
The basal ganglia: anatomy, physiology, and pharmacology. Psychiatr Clin North Am (2004) 1.02
Impaired delayed spatial win-shift behaviour on the eight arm radial maze following excitotoxic lesions of the medial prefrontal cortex in the rat. Behav Brain Res (2003) 0.98
Cognitive control in adolescents with neurofibromatosis type 1. Neuropsychology (2009) 0.96
Neural correlates of learning and working memory in the primate posterior parietal cortex. Neurobiol Learn Mem (2009) 0.92
Prefrontal executive function syndromes in children. J Child Neurol (2004) 0.91
A specific deficit in visuospatial simultaneous working memory in Down syndrome. J Intellect Disabil Res (2009) 0.89
Working memory and cognitive skills in individuals with Down syndrome. Child Neuropsychol (2009) 0.86
Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats. Horm Behav (2005) 0.86
A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet (2009) 12.96
Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Proc Natl Acad Sci U S A (2001) 6.39
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci (2010) 5.12
Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci (2004) 4.99
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36
The involvement of the anterior cingulate cortex in remote contextual fear memory. Science (2004) 4.29
Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia. Neuroimage (2004) 4.13
Shadow enhancers as a source of evolutionary novelty. Science (2008) 3.71
At clinical high risk for psychosis: outcome for nonconverters. Am J Psychiatry (2011) 3.66
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci (2008) 3.54
Neuronal competition and selection during memory formation. Science (2007) 3.48
North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research. Schizophr Bull (2007) 3.28
CREB required for the stability of new and reactivated fear memories. Nat Neurosci (2002) 3.28
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Neuron (2004) 3.16
Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia. Schizophr Bull (2007) 3.15
Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron (2008) 3.14
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp (2005) 2.93
Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study. Schizophr Bull (2009) 2.90
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell (2013) 2.71
Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65
Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J Neurosci (2004) 2.64
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol (2005) 2.62
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nat Neurosci (2009) 2.60
Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Arch Gen Psychiatry (2010) 2.54
Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo. Cell (2013) 2.42
Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci (2003) 2.35
Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. JAMA (2008) 2.30
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci (2006) 2.29
Promoter elements associated with RNA Pol II stalling in the Drosophila embryo. Proc Natl Acad Sci U S A (2008) 2.25
Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci (2006) 2.23
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. Am J Psychiatry (2014) 2.15
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms. Am J Psychiatry (2010) 2.12
Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron (2002) 2.09
Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am J Psychiatry (2002) 2.08
Properties of developmental gene regulatory networks. Proc Natl Acad Sci U S A (2008) 2.05
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A (2007) 2.04
Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schizophr Bull (2003) 2.04
New circuits for old memories: the role of the neocortex in consolidation. Neuron (2004) 2.02
Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia (2009) 1.99
Memory for context becomes less specific with time. Learn Mem (2007) 1.99
The corticostriatal pathway in Huntington's disease. Prog Neurobiol (2006) 1.99
Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals. Schizophr Res (2009) 1.98
Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol Aging (2005) 1.96
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry (2006) 1.93
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90
The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord (2010) 1.90
Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry (2007) 1.89
Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease. J Neurosci (2003) 1.88
Cortisol levels and risk for psychosis: initial findings from the North American prodrome longitudinal study. Biol Psychiatry (2013) 1.87
Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation. BMC Neurosci (2006) 1.84
Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry (2003) 1.83
Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Bipolar Disord (2009) 1.82
Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning. J Neurosci (2011) 1.82
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Neuron (2008) 1.81
Reversing neurodevelopmental disorders in adults. Neuron (2008) 1.80
Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol (2004) 1.80
North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment. Schizophr Res (2012) 1.79
Social cognition in schizophrenia, Part 1: performance across phase of illness. Schizophr Bull (2011) 1.77
The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord (2004) 1.75
The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV. J Child Adolesc Psychopharmacol (2005) 1.72
How the Dorsal gradient works: insights from postgenome technologies. Proc Natl Acad Sci U S A (2008) 1.70
Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci (2009) 1.70
Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci (2005) 1.68
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet (2009) 1.68
Learning and memory deficits in Notch mutant mice. Curr Biol (2003) 1.68
Neurocognitive performance and functional disability in the psychosis prodrome. Schizophr Res (2006) 1.67
Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array. Proc Natl Acad Sci U S A (2006) 1.66
White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry (2009) 1.65
A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am J Psychiatry (2003) 1.63
Insight into the relationship between impulsivity and substance abuse from studies using animal models. Alcohol Clin Exp Res (2010) 1.62
CaMKII binding to GluN2B is critical during memory consolidation. EMBO J (2012) 1.62
Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity. Neuron (2002) 1.58
The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res (2006) 1.57
Stability of recent and remote contextual fear memory. Learn Mem (2006) 1.57
The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry (2007) 1.57
MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci (2003) 1.56
Spatial regulation of microRNA gene expression in the Drosophila embryo. Proc Natl Acad Sci U S A (2005) 1.55