| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Engaging neuroscience to advance translational research in brain barrier biology.
|
Nat Rev Neurosci
|
2011
|
2.40
|
|
2
|
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo.
|
J Clin Invest
|
2002
|
1.90
|
|
3
|
Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.
|
Mol Pharmacol
|
2004
|
1.67
|
|
4
|
Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide.
|
Mol Pharmacol
|
2005
|
1.54
|
|
5
|
Brain delivery of camptothecin by means of solid lipid nanoparticles: formulation design, in vitro and in vivo studies.
|
Int J Pharm
|
2012
|
1.51
|
|
6
|
Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.
|
Mol Pharmacol
|
2004
|
1.42
|
|
7
|
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
|
J Med Chem
|
2009
|
1.25
|
|
8
|
Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.
|
Genomics
|
2002
|
1.18
|
|
9
|
Modulation of p-glycoprotein transport function at the blood-brain barrier.
|
Exp Biol Med (Maywood)
|
2005
|
1.16
|
|
10
|
Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency.
|
J Neurochem
|
2006
|
1.04
|
|
11
|
Choroid plexus epithelial monolayers--a cell culture model from porcine brain.
|
Cerebrospinal Fluid Res
|
2006
|
1.01
|
|
12
|
Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.
|
J Pharmacol Exp Ther
|
2009
|
1.01
|
|
13
|
Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus.
|
Biochim Biophys Acta
|
2010
|
0.92
|
|
14
|
Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries.
|
Br J Pharmacol
|
2003
|
0.92
|
|
15
|
Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.
|
Planta Med
|
2007
|
0.91
|
|
16
|
Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats.
|
Drug Metab Dispos
|
2008
|
0.90
|
|
17
|
Surveillance of siRNA integrity by FRET imaging.
|
Nucleic Acids Res
|
2007
|
0.90
|
|
18
|
Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries.
|
J Drug Target
|
2009
|
0.89
|
|
19
|
Delivery of nanoparticles to the brain detected by fluorescence microscopy.
|
Eur J Pharm Biopharm
|
2008
|
0.88
|
|
20
|
Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery.
|
Eur J Pharm Biopharm
|
2010
|
0.88
|
|
21
|
In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives.
|
Eur J Pharm Sci
|
2011
|
0.87
|
|
22
|
By-passing of P-glycoprotein using immunoliposomes.
|
J Drug Target
|
2002
|
0.87
|
|
23
|
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
|
Fitoterapia
|
2012
|
0.85
|
|
24
|
Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: true supersaturation vs. apparent solubility enhancement.
|
Int J Pharm
|
2012
|
0.85
|
|
25
|
The ABC of the blood-brain barrier - regulation of drug efflux pumps.
|
Curr Pharm Des
|
2011
|
0.84
|
|
26
|
Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule.
|
J Pharmacol Exp Ther
|
2002
|
0.84
|
|
27
|
Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine.
|
Cancer Genomics Proteomics
|
2010
|
0.84
|
|
28
|
Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy.
|
Am J Physiol Renal Physiol
|
2004
|
0.84
|
|
29
|
Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions.
|
Exp Brain Res
|
2003
|
0.83
|
|
30
|
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
|
Eur J Pharm Sci
|
2008
|
0.83
|
|
31
|
Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model.
|
PLoS One
|
2012
|
0.83
|
|
32
|
Confocal imaging of organic anion transport in intact rat choroid plexus.
|
Am J Physiol Renal Physiol
|
2002
|
0.83
|
|
33
|
Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".
|
Eur J Pharm Sci
|
2013
|
0.82
|
|
34
|
Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound.
|
Eur J Pharm Sci
|
2012
|
0.82
|
|
35
|
Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system.
|
Eur J Pharm Biopharm
|
2007
|
0.81
|
|
36
|
In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules.
|
Eur J Pharm Biopharm
|
2010
|
0.81
|
|
37
|
Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers.
|
Eur J Pharm Biopharm
|
2011
|
0.81
|
|
38
|
The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility.
|
Int J Nanomedicine
|
2012
|
0.81
|
|
39
|
Transport of a fluorescent cAMP analog in teleost proximal tubules.
|
Am J Physiol Regul Integr Comp Physiol
|
2007
|
0.81
|
|
40
|
Formation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media.
|
Eur J Pharm Sci
|
2010
|
0.81
|
|
41
|
Stability of liposomes containing bio-enhancers and tetraether lipids in simulated gastro-intestinal fluids.
|
Int J Pharm
|
2010
|
0.81
|
|
42
|
Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier.
|
Cerebrospinal Fluid Res
|
2010
|
0.80
|
|
43
|
Xenobiotic efflux pumps in isolated fish brain capillaries.
|
Am J Physiol Regul Integr Comp Physiol
|
2002
|
0.80
|
|
44
|
Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters.
|
Am J Physiol Gastrointest Liver Physiol
|
2003
|
0.80
|
|
45
|
Fluorescein-methotrexate transport in dogfish shark (Squalus acanthias) choroid plexus.
|
Am J Physiol Regul Integr Comp Physiol
|
2006
|
0.80
|
|
46
|
Development of a new method to assess nanocrystal dissolution based on light scattering.
|
Pharm Res
|
2012
|
0.80
|
|
47
|
Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats.
|
Drug Metab Dispos
|
2008
|
0.80
|
|
48
|
Oral peptide delivery by tetraether lipid liposomes.
|
Int J Pharm
|
2011
|
0.80
|
|
49
|
NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways.
|
J Transl Med
|
2013
|
0.79
|
|
50
|
Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus.
|
J Neurochem
|
2010
|
0.79
|
|
51
|
St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier.
|
Pharm Res
|
2010
|
0.79
|
|
52
|
What is the mechanism behind increased permeation rate of a poorly soluble drug from aqueous dispersions of an amorphous solid dispersion?
|
J Pharm Sci
|
2014
|
0.79
|
|
53
|
Physicochemical characterization and in vitro permeation of an indirubin derivative.
|
Eur J Pharm Sci
|
2013
|
0.79
|
|
54
|
BCRP at the blood-brain barrier: genomic regulation by 17β-estradiol.
|
Mol Pharm
|
2010
|
0.79
|
|
55
|
Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats.
|
J Pharm Sci
|
2013
|
0.79
|
|
56
|
Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties.
|
J Cell Mol Med
|
2010
|
0.78
|
|
57
|
Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus.
|
Am J Physiol Regul Integr Comp Physiol
|
2008
|
0.78
|
|
58
|
In situ formation of nanoparticles upon dispersion of melt extrudate formulations in aqueous medium assessed by asymmetrical flow field-flow fractionation.
|
J Pharm Biomed Anal
|
2010
|
0.78
|
|
59
|
Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system.
|
Pharm Res
|
2003
|
0.78
|
|
60
|
Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles.
|
Eur J Pharm Biopharm
|
2010
|
0.78
|
|
61
|
Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis.
|
Int J Pharm
|
2012
|
0.78
|
|
62
|
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
|
J Nat Prod
|
2012
|
0.78
|
|
63
|
In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay: the influence of nonionic surfactants.
|
J Pharm Pharmacol
|
2011
|
0.78
|
|
64
|
Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis.
|
Comp Biochem Physiol B Biochem Mol Biol
|
2006
|
0.78
|
|
65
|
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
|
Fitoterapia
|
2012
|
0.77
|
|
66
|
Dynamic regulation of P-glycoprotein in human brain capillaries.
|
Mol Pharm
|
2013
|
0.77
|
|
67
|
A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2).
|
Eur J Pharm Biopharm
|
2009
|
0.77
|
|
68
|
Modification with organometallic compounds improves crossing of the blood-brain barrier of [Leu5]-enkephalin derivatives in an in vitro model system.
|
Chembiochem
|
2009
|
0.77
|
|
69
|
In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii.
|
Planta Med
|
2007
|
0.77
|
|
70
|
Establishment of optimized MDCK cell lines for reliable efflux transport studies.
|
J Pharm Sci
|
2014
|
0.76
|
|
71
|
Biological effects of acrylamide after daily ingestion of various foods in comparison to water: a study in rats.
|
Mol Nutr Food Res
|
2010
|
0.76
|
|
72
|
Formulation optimization of itraconazole loaded PEGylated liposomes for parenteral administration by using design of experiments.
|
Int J Pharm
|
2013
|
0.75
|
|
73
|
A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture.
|
Brain Res
|
2013
|
0.75
|
|
74
|
Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier.
|
Pharm Res
|
2015
|
0.75
|
|
75
|
Alkamides from Echinacea angustifolia Interact with P-glycoprotein of primary brain capillary endothelial cells isolated from porcine brain blood vessels.
|
Planta Med
|
2013
|
0.75
|
|
76
|
Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding?
|
J Med Chem
|
2014
|
0.75
|
|
77
|
Oral bioavailability of ketoprofen in suspension and solution formulations in rats: the influence of poloxamer 188.
|
J Pharm Pharmacol
|
2012
|
0.75
|
|
78
|
From blood to brain and vice versa: transport processes in choroid plexus can be studied in vitro.
|
ALTEX
|
2007
|
0.75
|
|
79
|
Regional absorption of fexofenadine in rat intestine.
|
Eur J Pharm Sci
|
2010
|
0.75
|
|
80
|
Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole.
|
J Pharm Sci
|
2014
|
0.75
|
|
81
|
Application of simulated intestinal fluid on the phospholipid vesicle-based drug permeation assay.
|
Int J Pharm
|
2011
|
0.75
|
|
82
|
In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems.
|
J Pharm Pharmacol
|
2014
|
0.75
|
|
83
|
Rapid assessment of p-glycoprotein-drug interactions at the blood-brain barrier.
|
Anal Biochem
|
2006
|
0.75
|
|
84
|
In-vitro permeability screening of melt extrudate formulations containing poorly water-soluble drug compounds using the phospholipid vesicle-based barrier.
|
J Pharm Pharmacol
|
2010
|
0.75
|
|
85
|
Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.
|
Pharm Res
|
2014
|
0.75
|