Published in Genome Med on August 06, 2010
Pharmacogenomics and individualized medicine: translating science into practice. Clin Pharmacol Ther (2012) 2.48
Opportunities and challenges of cloud computing to improve health care services. J Med Internet Res (2011) 1.72
Resources and costs for microbial sequence analysis evaluated using virtual machines and cloud computing. PLoS One (2011) 1.41
Bioinformatics clouds for big data manipulation. Biol Direct (2012) 1.29
Cost-effective cloud computing: a case study using the comparative genomics tool, roundup. Evol Bioinform Online (2010) 1.24
Opportunities and challenges for the life sciences community. OMICS (2012) 1.21
Unifying immunology with informatics and multiscale biology. Nat Immunol (2014) 1.15
An initial log analysis of usage patterns on a research networking system. Clin Transl Sci (2012) 1.12
GobyWeb: simplified management and analysis of gene expression and DNA methylation sequencing data. PLoS One (2013) 1.09
Translational bioinformatics: linking the molecular world to the clinical world. Clin Pharmacol Ther (2012) 1.05
CloudAligner: A fast and full-featured MapReduce based tool for sequence mapping. BMC Res Notes (2011) 1.05
Genetic data and electronic health records: a discussion of ethical, logistical and technological considerations. J Am Med Inform Assoc (2013) 1.03
Advantages of genomic complexity: bioinformatics opportunities in microRNA cancer signatures. J Am Med Inform Assoc (2011) 0.93
Genomics Virtual Laboratory: A Practical Bioinformatics Workbench for the Cloud. PLoS One (2015) 0.93
Scientific research in the age of omics: the good, the bad, and the sloppy. J Am Med Inform Assoc (2012) 0.91
Cloud prediction of protein structure and function with PredictProtein for Debian. Biomed Res Int (2013) 0.91
Toward real-time Monte Carlo simulation using a commercial cloud computing infrastructure. Phys Med Biol (2011) 0.82
A case study for cloud based high throughput analysis of NGS data using the globus genomics system. Comput Struct Biotechnol J (2014) 0.82
Needs Assessment for Research Use of High-Throughput Sequencing at a Large Academic Medical Center. PLoS One (2015) 0.81
A cloud-based approach to medical NLP. AMIA Annu Symp Proc (2011) 0.76
Parallel classification and feature selection in microarray data using SPRINT. Concurr Comput (2014) 0.75
GenomeVIP: a cloud platform for genomic variant discovery and interpretation. Genome Res (2017) 0.75
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
CloudBurst: highly sensitive read mapping with MapReduce. Bioinformatics (2009) 20.45
NCBI GEO: mining tens of millions of expression profiles--database and tools update. Nucleic Acids Res (2006) 19.42
Translational bioinformatics: coming of age. J Am Med Inform Assoc (2008) 2.81
Cloud computing. Bioinformatics (2009) 1.94
Disease signatures are robust across tissues and experiments. Mol Syst Biol (2009) 1.93
Advances in translational bioinformatics: computational approaches for the hunting of disease genes. Brief Bioinform (2009) 1.27
Translational bioinformatics applications in genome medicine. Genome Med (2009) 1.19
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Clinical assessment incorporating a personal genome. Lancet (2010) 10.18
Performance comparison of exome DNA sequencing technologies. Nat Biotechnol (2011) 7.11
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol (2012) 6.38
Ontology-driven indexing of public datasets for translational bioinformatics. BMC Bioinformatics (2009) 6.31
Performance comparison of whole-genome sequencing platforms. Nat Biotechnol (2011) 5.79
Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77
Evaluation of text data mining for database curation: lessons learned from the KDD Challenge Cup. Bioinformatics (2003) 5.77
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One (2010) 4.42
Rutabaga by any other name: extracting biological names. J Biomed Inform (2002) 3.74
FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell (2009) 3.54
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27
Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol (2010) 3.23
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
Data preparation and interannotator agreement: BioCreAtIvE task 1B. BMC Bioinformatics (2005) 3.19
Protein-Protein Docking Benchmark 2.0: an update. Proteins (2005) 3.13
Challenges in the clinical application of whole-genome sequencing. Lancet (2010) 2.92
Finding disease-related genomic experiments within an international repository: first steps in translational bioinformatics. AMIA Annu Symp Proc (2006) 2.88
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Computerized recruiting for clinical trials in real time. Ann Emerg Med (2003) 2.59
Integrating statistical pair potentials into protein complex prediction. Proteins (2007) 2.53
Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform (2011) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
Silver nanoparticles: partial oxidation and antibacterial activities. J Biol Inorg Chem (2007) 2.50
Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50
AILUN: reannotating gene expression data automatically. Nat Methods (2007) 2.47
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov (2013) 2.46
MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44
Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J Proteome Res (2006) 2.43
Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42
BioWarehouse: a bioinformatics database warehouse toolkit. BMC Bioinformatics (2006) 2.40
Structural requirements for the assembly of Norwalk virus-like particles. J Virol (2002) 2.38
Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc (2011) 2.36
Multifunctional Alloys Obtained via a Dislocation-Free Plastic Deformation Mechanism. Science (2003) 2.33
Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24
RDOCK: refinement of rigid-body protein docking predictions. Proteins (2003) 2.24
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
A nutrient-wide association study on blood pressure. Circulation (2012) 2.19
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One (2010) 2.10
Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet (2012) 2.02
Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96
Disease signatures are robust across tissues and experiments. Mol Syst Biol (2009) 1.93
Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87
In silico research in the era of cloud computing. Nat Biotechnol (2010) 1.81
Automating document classification for the Immune Epitope Database. BMC Bioinformatics (2007) 1.76
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation. Plant Cell (2009) 1.71
Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis. Diabetes Care (2013) 1.70
Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int (2009) 1.68
The basic helix-loop-helix transcription factor MYC2 directly represses PLETHORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis. Plant Cell (2011) 1.65
ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. Proteins (2005) 1.61
Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput (2008) 1.61
FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol (2008) 1.58
Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas (2009) 1.58
Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun (Camb) (2005) 1.57
Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care (2010) 1.55
Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics (2010) 1.55
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet (2012) 1.55
Silver nanoparticles inhibit hepatitis B virus replication. Antivir Ther (2008) 1.53
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat Cell Biol (2009) 1.49
ImmPort: disseminating data to the public for the future of immunology. Immunol Res (2014) 1.48
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet (2013) 1.48
Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A (2009) 1.47
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation. J Exp Med (2013) 1.47
Effects of lifestyle intervention improve cardiovascular disease risk factors in community-based menopausal transition and early postmenopausal women in China. Menopause (2014) 1.42
Mean platelet volume predicts left descending artery occlusion in patients with non-ST-elevation myocardial infarction. Platelets (2013) 1.41
Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light. Biosens Bioelectron (2010) 1.40
Retracted Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients. Eur J Med Res (2014) 1.39
Dynamism in gene expression across multiple studies. Physiol Genomics (2009) 1.36
The "etiome": identification and clustering of human disease etiological factors. BMC Bioinformatics (2009) 1.35
Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes. Bioinformatics (2007) 1.34
Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver. Cancer Sci (2008) 1.34
Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol (2008) 1.33
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol (2010) 1.33
Effect of cytarabine and decitabine in combination in human leukemic cell lines. Clin Cancer Res (2007) 1.33