Published in Aging Cell on August 01, 2004
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med (2005) 5.01
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69
Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One (2009) 2.62
A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci U S A (2007) 2.15
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 2.05
Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. J Clin Invest (2011) 2.02
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proc Natl Acad Sci U S A (2008) 2.02
Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell (2010) 1.90
The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet (2009) 1.81
Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol (2008) 1.36
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. Exp Cell Res (2007) 1.36
Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur J Hum Genet (2009) 1.34
A weighted average difference method for detecting differentially expressed genes from microarray data. Algorithms Mol Biol (2008) 1.27
Lamins at the crossroads of mechanosignaling. Genes Dev (2015) 1.23
Identification of differential protein interactors of lamin A and progerin. Nucleus (2010) 1.14
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells. Aging (Albany NY) (2015) 1.08
Mapping of lamin A- and progerin-interacting genome regions. Chromosoma (2012) 1.01
Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. Clin Interv Aging (2008) 0.99
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition. PLoS One (2010) 0.99
Accelerated aging syndromes, are they relevant to normal human aging? Aging (Albany NY) (2011) 0.97
Lamin A, farnesylation and aging. Exp Cell Res (2011) 0.97
Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles. Stem Cells Transl Med (2012) 0.94
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife (2014) 0.93
Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Hum Mol Genet (2009) 0.88
Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport. J Cell Biol (2013) 0.87
Aging--RNA in development and disease. Wiley Interdiscip Rev RNA (2011) 0.87
Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. PLoS One (2011) 0.86
T-STAG: resource and web-interface for tissue-specific transcripts and genes. Nucleic Acids Res (2005) 0.86
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins. Genes Dev (2015) 0.85
Embryonic senescence and laminopathies in a progeroid zebrafish model. PLoS One (2011) 0.84
Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging. Aging Cell (2015) 0.84
Influences of lamin A levels on induction of pluripotent stem cells. Biol Open (2012) 0.83
Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J (2015) 0.83
Distributional fold change test - a statistical approach for detecting differential expression in microarray experiments. Algorithms Mol Biol (2012) 0.83
Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal (2009) 0.82
A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY) (2012) 0.82
Collagen expression in fibroblasts with a novel LMNA mutation. Biochem Biophys Res Commun (2006) 0.82
Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations. Ageing Res Rev (2016) 0.81
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell (2015) 0.81
Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice. J Anat (2008) 0.79
A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome. Pediatr Radiol (2012) 0.79
Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches. J Biomed Biotechnol (2010) 0.79
Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer). Gene Regul Syst Bio (2011) 0.79
Investigation of age-related changes in LMNA splicing and expression of progerin in human skeletal muscles. Int J Clin Exp Pathol (2013) 0.78
Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting. Nucleus (2014) 0.78
Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS). PLoS One (2011) 0.78
Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior. Hum Mol Genet (2014) 0.78
Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome. J Gerontol A Biol Sci Med Sci (2011) 0.76
Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis. Int J Clin Exp Pathol (2013) 0.76
Global transcriptional changes caused by an EDMD mutation correlate to tissue specific disease phenotypes in C. elegans. Nucleus (2016) 0.75
Skin Disease in Laminopathy-Associated Premature Aging. J Invest Dermatol (2015) 0.75
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Clinical assessment incorporating a personal genome. Lancet (2010) 10.18
Performance comparison of exome DNA sequencing technologies. Nat Biotechnol (2011) 7.11
Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol (2012) 6.38
Ontology-driven indexing of public datasets for translational bioinformatics. BMC Bioinformatics (2009) 6.31
Cellular senescence in aging primates. Science (2006) 6.24
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91
Performance comparison of whole-genome sequencing platforms. Nat Biotechnol (2011) 5.79
Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One (2010) 4.42
FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell (2009) 3.54
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27
Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol (2010) 3.23
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res (2007) 2.94
Challenges in the clinical application of whole-genome sequencing. Lancet (2010) 2.92
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83
A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem (2003) 2.69
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Computerized recruiting for clinical trials in real time. Ann Emerg Med (2003) 2.59
Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform (2011) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50
AILUN: reannotating gene expression data automatically. Nat Methods (2007) 2.47
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov (2013) 2.46
MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44
Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42
Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc (2011) 2.36
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol (2002) 2.27
Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells (2005) 2.25
Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
A nutrient-wide association study on blood pressure. Circulation (2012) 2.19
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One (2010) 2.10
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (2008) 2.09
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet (2012) 2.02
Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell (2012) 1.99
Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96
Effect of duration of fixation on quantitative reverse transcription polymerase chain reaction analyses. Mod Pathol (2002) 1.95
Disease signatures are robust across tissues and experiments. Mol Syst Biol (2009) 1.93
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature (2009) 1.89
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
In silico research in the era of cloud computing. Nat Biotechnol (2010) 1.81
Proteomic profiling of Myc-associated proteins. Cell Cycle (2010) 1.80
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis. Diabetes Care (2013) 1.70
Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int (2009) 1.68
The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells. Cloning Stem Cells (2005) 1.67
Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells (2007) 1.65
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell (2013) 1.62
Translational bioinformatics in the cloud: an affordable alternative. Genome Med (2010) 1.61
Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput (2008) 1.61
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol (2008) 1.58
Highlights of the 2007 Progeria Research Foundation scientific workshop: progress in translational science. J Gerontol A Biol Sci Med Sci (2008) 1.56
Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care (2010) 1.55
Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics (2010) 1.55
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet (2012) 1.55
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
ImmPort: disseminating data to the public for the future of immunology. Immunol Res (2014) 1.48
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet (2013) 1.48
Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A (2009) 1.47
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation. J Exp Med (2013) 1.47
CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol (2003) 1.46
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep (2012) 1.40
Dynamism in gene expression across multiple studies. Physiol Genomics (2009) 1.36
The "etiome": identification and clustering of human disease etiological factors. BMC Bioinformatics (2009) 1.35
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Mol Biol Cell (2003) 1.34
Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes. Bioinformatics (2007) 1.34
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol (2008) 1.33
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol (2006) 1.32
Sex differences in reported pain across 11,000 patients captured in electronic medical records. J Pain (2012) 1.32
Involvement of the INK4a/Arf gene locus in senescence. Aging Cell (2003) 1.28
Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol (2010) 1.27
Novel integration of hospital electronic medical records and gene expression measurements to identify genetic markers of maturation. Pac Symp Biocomput (2008) 1.27
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma. J Clin Invest (2011) 1.27
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci (2002) 1.26
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) (2013) 1.26
Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev (2005) 1.25
GeneChaser: identifying all biological and clinical conditions in which genes of interest are differentially expressed. BMC Bioinformatics (2008) 1.24
Extreme evolutionary disparities seen in positive selection across seven complex diseases. PLoS One (2010) 1.23
The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell (2012) 1.23
Systematic functional regulatory assessment of disease-associated variants. Proc Natl Acad Sci U S A (2013) 1.22
Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab (2002) 1.21
mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram (2010) 1.21