Published in Cell on August 06, 2010
Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell (2012) 1.99
p53-Dependent induction of PVT1 and miR-1204. J Biol Chem (2011) 1.56
Potential roles of microRNAs in regulating long intergenic noncoding RNAs. BMC Med Genomics (2013) 1.19
E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression. Genes Dev (2012) 1.12
Sizing up long non-coding RNAs: do lncRNAs have secondary and tertiary structure? Bioarchitecture (2012) 0.95
A comprehensive and high-resolution genome-wide response of p53 to stress. Cell Rep (2014) 0.92
The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia. PLoS Genet (2015) 0.78
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56
Transcriptional regulation by p53. Cold Spring Harb Perspect Biol (2010) 3.16
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
P53 and prognosis: new insights and further complexity. Cell (2005) 2.28
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07
p53 linear diffusion along DNA requires its C terminus. Mol Cell (2004) 2.03
Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell (2009) 2.00
The Chk2 protein kinase. DNA Repair (Amst) (2004) 1.85
Unleashing the power of p53: lessons from mice and men. Genes Dev (2006) 1.76
APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62
Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell (2002) 1.57
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
p53-Dependent induction of PVT1 and miR-1204. J Biol Chem (2011) 1.56
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol (2005) 1.56
Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle (2009) 1.55
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol Cell Biol (2002) 1.43
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.40
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39
p73alpha regulation by Chk1 in response to DNA damage. Mol Cell Biol (2003) 1.36
The C terminus of p53 binds the N-terminal domain of MDM2. Nat Struct Mol Biol (2010) 1.35
p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer. Clin Cancer Res (2003) 1.35
The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene (2002) 1.35
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A (2012) 1.30
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem (2003) 1.29
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J Biol Chem (2006) 1.28
Mutational analysis of the p53 core domain L1 loop. J Biol Chem (2006) 1.25
p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation. J Cell Sci (2008) 1.24
Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One (2013) 1.22
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol (2006) 1.20
The S phase checkpoint: when the crowd meets at the fork. Semin Cell Dev Biol (2005) 1.20
MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A (2013) 1.19
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell (2012) 1.19
p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation. Proc Natl Acad Sci U S A (2011) 1.10
Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle (2008) 1.09
Mutant p53 gain of function: the NF-Y connection. Cancer Cell (2006) 1.08
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem (2003) 1.05
P53 and aging: A fresh look at an old paradigm. Aging (Albany NY) (2010) 1.05
p53 in the cytoplasm: a question of overkill? Cell (2004) 1.05
Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J Biol Chem (2002) 1.04
Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol Cell Biol (2005) 1.00
DECOD: fast and accurate discriminative DNA motif finding. Bioinformatics (2011) 0.98
p53 and p73 display common and distinct requirements for sequence specific binding to DNA. Nucleic Acids Res (2006) 0.98
p53 and Metabolism: The GAMT Connection. Mol Cell (2009) 0.98
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97
Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block. J Biol Chem (2003) 0.96
p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner. J Cell Sci (2008) 0.95
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov (2011) 0.94
Deconstruction of p53 functions and regulation. Oncogene (2002) 0.94
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability. Nucleic Acids Res (2013) 0.88
Mdm2 and MdmX as Regulators of Gene Expression. Genes Cancer (2012) 0.87
Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem (2007) 0.87
p53 leans on its siblings. Cancer Cell (2002) 0.85
The linchpin? Pin1 meets p73. Cancer Cell (2004) 0.81
Replication of damaged DNA in vitro is blocked by p53. Nucleic Acids Res (2003) 0.80
Ribosomal protein L37 and the p53 network. Cell Cycle (2010) 0.80
Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein. Cell Cycle (2009) 0.79
Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A. Mol Cell Biol (2008) 0.79
Deconstructing nucleotide binding activity of the Mdm2 RING domain. Nucleic Acids Res (2010) 0.78
Dissimilar DNA binding by p53 in normal and tumor-derived cells. Cell Cycle (2011) 0.78
Mutant p53 succumbs to starvation. Cell Cycle (2013) 0.77
The p53-HAT connection: PCAF rules? Cell Cycle (2012) 0.75
Anything but simple: a phosphorylation-driven toggle within Brd4 triggers gene-specific transcriptional activation. Mol Cell (2013) 0.75