Transcriptional regulation by p53.

Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol (2010) 3.65

Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37

A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell (2013) 2.60

p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A (2011) 1.97

Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity? Transcription (2011) 1.94

Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72

PTEN interacts with histone H1 and controls chromatin condensation. Cell Rep (2014) 1.60

Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. Genome Biol (2013) 1.47

Another fork in the road--life or death decisions by the tumour suppressor p53. EMBO Rep (2013) 1.43

Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population. PLoS One (2016) 1.39

A pathophysiological view of the long non-coding RNA world. Oncotarget (2014) 1.36

p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33

The transcription factor p53: not a repressor, solely an activator. Cell Cycle (2014) 1.23

DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation. J Biol Chem (2012) 1.21

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature. Nat Commun (2014) 1.18

Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. Curr Genet (2015) 1.16

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression. Genes Dev (2012) 1.12

Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res (2013) 1.11

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol (2012) 1.09

Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet (2013) 1.08

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. Nat Commun (2015) 1.08

Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell Death Differ (2014) 1.06

p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis (2012) 1.06

Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle (2011) 1.06

Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle (2010) 1.05

Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis. Nucleic Acids Res (2016) 1.05

The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ (2013) 1.04

Single-molecule analysis of transcription factor binding at transcription sites in live cells. Nat Commun (2014) 1.04

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. Genes Dev (2011) 1.03

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res (2013) 1.02

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma. Cancer Sci (2014) 1.02

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. Cell Death Dis (2013) 1.01

Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils. Expert Opin Ther Targets (2012) 1.01

Histone deacetylase inhibitors and cell death. Cell Mol Life Sci (2014) 1.00

NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol (2015) 0.99

Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex. Oncotarget (2015) 0.98

Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proc Natl Acad Sci U S A (2012) 0.98

mTORC1 and p53: clash of the gods? Cell Cycle (2013) 0.98

SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. Arch Biochem Biophys (2014) 0.98

Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci U S A (2011) 0.97

Crosstalk between p53 and TGF-β Signalling. J Signal Transduct (2012) 0.95

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. Proc Natl Acad Sci U S A (2016) 0.94

Selective killing of p53-deficient cancer cells by SP600125. EMBO Mol Med (2012) 0.94

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks. Nucleic Acids Res (2016) 0.93

TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity. Genome Res (2014) 0.93

A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep (2014) 0.93

Not all p53 gain-of-function mutants are created equal. Cell Death Differ (2013) 0.92

Pharmacological activation of p53 in cancer cells. Curr Pharm Des (2011) 0.92

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism. J Inflamm (Lond) (2014) 0.92

Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity. Cell Cycle (2012) 0.91

Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein. J Biol Chem (2011) 0.91

Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer (2013) 0.91

Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem (2011) 0.90

Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. Aging (Albany NY) (2012) 0.89

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89

p53 requires an intact C-terminal domain for DNA binding and transactivation. J Mol Biol (2011) 0.89

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo. Oncotarget (2015) 0.89

Senescence regulation by the p53 protein family. Methods Mol Biol (2013) 0.88

NuMA is required for the selective induction of p53 target genes. Mol Cell Biol (2013) 0.88

Mdm2 and MdmX as Regulators of Gene Expression. Genes Cancer (2012) 0.87

Dominant effects of Δ40p53 on p53 function and melanoma cell fate. J Invest Dermatol (2013) 0.87

Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res (2015) 0.86

Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage. Biochem Res Int (2012) 0.86

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53. Nat Commun (2015) 0.86

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. Oncotarget (2014) 0.86

Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A (2016) 0.86

Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription. Oncogene (2012) 0.85

Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm. PLoS One (2013) 0.85

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity? Cancer Lett (2016) 0.85

p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes. J Biol Chem (2012) 0.84

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84

Transcriptome profiling of the theca interna in transition from small to large antral ovarian follicles. PLoS One (2014) 0.84

Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res (2013) 0.84

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res (2012) 0.84

Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic. Genome Res (2016) 0.83

Post-transcriptional regulation of DNA damage-responsive gene expression. Antioxid Redox Signal (2013) 0.83

Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro (2015) 0.83

Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells. PLoS Genet (2014) 0.83

Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy. J Biol Inorg Chem (2014) 0.83

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. PLoS One (2013) 0.83

Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci (2014) 0.83

E2F1 and p53 transcription factors as accessory factors for nucleotide excision repair. Int J Mol Sci (2012) 0.82

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (2012) 0.82

Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiol Genomics (2012) 0.82

Review of Osteosarcoma and Current Management. Rheumatol Ther (2016) 0.81

Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis. Cancer Cell Int (2013) 0.81

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ. Cell Death Differ (2014) 0.81

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites. Oncotarget (2014) 0.81

p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3. Mol Cell Biol (2013) 0.81

p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget (2015) 0.81

p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA. PLoS One (2015) 0.81

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene (2015) 0.81

Whole-genome cartography of p53 response elements ranked on transactivation potential. BMC Genomics (2015) 0.80

Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor. Mol Cell Biol (2014) 0.80

β-Catenin C-terminal signals suppress p53 and are essential for artery formation. Nat Commun (2016) 0.80

Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genet (2015) 0.80

Multifaceted functions of Siva-1: more than an Indian God of Destruction. Protein Cell (2012) 0.80

Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. PLoS One (2014) 0.80

Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci (2015) 0.79

The role of chromatin during transcription. Cell (2007) 26.48

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42

A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65

Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79

p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55

p53: puzzle and paradigm. Genes Dev (1996) 13.16

Definition of a consensus binding site for p53. Nat Genet (1992) 12.76

The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat (2002) 12.39

Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05

Modes of p53 regulation. Cell (2009) 9.31

Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

p53 function and dysfunction. Cell (1992) 7.73

The general transcription factors of RNA polymerase II. Genes Dev (1996) 7.15

p53 isoforms can regulate p53 transcriptional activity. Genes Dev (2005) 6.76

Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer (2004) 6.67

A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol (1992) 6.56

The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev (2000) 5.93

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64

The general transcription machinery and general cofactors. Crit Rev Biochem Mol Biol (2006) 5.52

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30

Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25

Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12

Recruitment of p300/CBP in p53-dependent signal pathways. Cell (1997) 5.10

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem (2001) 4.21

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06

Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci U S A (1992) 4.06

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell (2001) 3.74

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell (2005) 3.73

Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol (1998) 3.61

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55

Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev (1999) 3.41

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29

Structural basis of DNA recognition by p53 tetramers. Mol Cell (2006) 3.29

p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27

Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science (2003) 3.21

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell (2007) 3.20

A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol (2008) 3.13

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene (2002) 3.12

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell (2003) 3.05

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature (2002) 3.02

The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98

Phosphorylation of p53 serine 15 increases interaction with CBP. J Biol Chem (1998) 2.97

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature (2002) 2.94

Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94

CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol Cell (2007) 2.88

RNA polymerases I and III, growth control and cancer. Nat Rev Mol Cell Biol (2005) 2.77

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71

Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev (1997) 2.70

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66

p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol (2005) 2.65

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50

p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem (2003) 2.43

BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene (1998) 2.39

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription. Mol Cell Biol (1993) 2.37

Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ (2003) 2.30

Allosteric activation of latent p53 tetramers. Curr Biol (1994) 2.25

The RNA polymerase II machinery: structure illuminates function. Cell (2002) 2.24

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. EMBO J (1993) 2.21

p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev (2007) 2.21

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol (2006) 2.21

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet (2006) 2.20

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell (2004) 2.16

MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Mol Cell (2006) 2.15

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol (2005) 2.13

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol (2007) 2.13

Repression of RNA polymerase I transcription by the tumor suppressor p53. Mol Cell Biol (2000) 2.10

p53 represses ribosomal gene transcription. Oncogene (1999) 2.08

p53 linear diffusion along DNA requires its C terminus. Mol Cell (2004) 2.03

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem (2007) 2.03

A polymorphic microsatellite that mediates induction of PIG3 by p53. Nat Genet (2002) 1.97

Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol (2005) 1.96

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell (2001) 1.88

Kinetics of p53 binding to promoter sites in vivo. Mol Cell Biol (2001) 1.87

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85

RB regulates the stability and the apoptotic function of p53 via MDM2. Mol Cell (1999) 1.85

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J (2005) 1.85

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol (2002) 1.83

How p53 binds DNA as a tetramer. EMBO J (1998) 1.82

p300/CBP/p53 interaction and regulation of the p53 response. Eur J Biochem (2001) 1.77

Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75

Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

Mutant p53: one name, many proteins. Genes Dev (2012) 4.33

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56

TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15

P53 and prognosis: new insights and further complexity. Cell (2005) 2.28

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07

p53 linear diffusion along DNA requires its C terminus. Mol Cell (2004) 2.03

Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell (2009) 2.00

The Chk2 protein kinase. DNA Repair (Amst) (2004) 1.85

Unleashing the power of p53: lessons from mice and men. Genes Dev (2006) 1.76

APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62

Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell (2002) 1.57

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57

p53-Dependent induction of PVT1 and miR-1204. J Biol Chem (2011) 1.56

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol (2005) 1.56

Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle (2009) 1.55

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol Cell Biol (2002) 1.43

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.40

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39

Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39

p73alpha regulation by Chk1 in response to DNA damage. Mol Cell Biol (2003) 1.36

The C terminus of p53 binds the N-terminal domain of MDM2. Nat Struct Mol Biol (2010) 1.35

p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer. Clin Cancer Res (2003) 1.35

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene (2002) 1.35

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A (2012) 1.30

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem (2003) 1.29

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J Biol Chem (2006) 1.28

Mutational analysis of the p53 core domain L1 loop. J Biol Chem (2006) 1.25

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation. J Cell Sci (2008) 1.24

Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One (2013) 1.22

p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol (2006) 1.20

The S phase checkpoint: when the crowd meets at the fork. Semin Cell Dev Biol (2005) 1.20

MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A (2013) 1.19

Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell (2012) 1.19

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation. Proc Natl Acad Sci U S A (2011) 1.10

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle (2008) 1.09

Mutant p53 gain of function: the NF-Y connection. Cancer Cell (2006) 1.08

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem (2003) 1.05

P53 and aging: A fresh look at an old paradigm. Aging (Albany NY) (2010) 1.05

p53 in the cytoplasm: a question of overkill? Cell (2004) 1.05

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J Biol Chem (2002) 1.04

Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol Cell Biol (2005) 1.00

p53 and p73 display common and distinct requirements for sequence specific binding to DNA. Nucleic Acids Res (2006) 0.98

p53 and Metabolism: The GAMT Connection. Mol Cell (2009) 0.98

DECOD: fast and accurate discriminative DNA motif finding. Bioinformatics (2011) 0.98

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97

Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block. J Biol Chem (2003) 0.96

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner. J Cell Sci (2008) 0.95

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov (2011) 0.94

Deconstruction of p53 functions and regulation. Oncogene (2002) 0.94

Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability. Nucleic Acids Res (2013) 0.88

Noncoding RNAs: the missing "linc" in p53-mediated repression. Cell (2010) 0.88

Mdm2 and MdmX as Regulators of Gene Expression. Genes Cancer (2012) 0.87

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem (2007) 0.87

p53 leans on its siblings. Cancer Cell (2002) 0.85

The linchpin? Pin1 meets p73. Cancer Cell (2004) 0.81

Replication of damaged DNA in vitro is blocked by p53. Nucleic Acids Res (2003) 0.80

Ribosomal protein L37 and the p53 network. Cell Cycle (2010) 0.80

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein. Cell Cycle (2009) 0.79

Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A. Mol Cell Biol (2008) 0.79

Dissimilar DNA binding by p53 in normal and tumor-derived cells. Cell Cycle (2011) 0.78

Deconstructing nucleotide binding activity of the Mdm2 RING domain. Nucleic Acids Res (2010) 0.78

Mutant p53 succumbs to starvation. Cell Cycle (2013) 0.77

The p53-HAT connection: PCAF rules? Cell Cycle (2012) 0.75

Anything but simple: a phosphorylation-driven toggle within Brd4 triggers gene-specific transcriptional activation. Mol Cell (2013) 0.75