Published in Biochem Biophys Res Commun on July 15, 1991
The role of mitochondria in aging. J Clin Invest (2013) 2.71
Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med (2012) 1.67
Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins. PLoS Genet (2011) 1.60
Mitochondrial mutational spectra in human cells and tissues. Proc Natl Acad Sci U S A (1997) 1.45
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta (2009) 1.31
Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy. Ann Neurol (2010) 1.10
Age-related human mtDNA deletions: a heterogeneous set of deletions arising at a single pair of directly repeated sequences. Am J Hum Genet (1994) 0.99
Mutations in mitochondrial tRNA genes: non-linkage with syndromes of Wolfram and chronic progressive external ophthalmoplegia. Nucleic Acids Res (1992) 0.95
The mutation rate of the human mtDNA deletion mtDNA4977. Am J Hum Genet (1996) 0.92
Mitochondrial-nuclear epistasis: implications for human aging and longevity. Ageing Res Rev (2010) 0.89
Role of reactive oxygen species in cardiovascular aging. Mol Cell Biochem (1997) 0.88
A specific 4977-bp deletion of mitochondrial DNA in human ageing skin. Arch Dermatol Res (1994) 0.85
Major changes in complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:coenzyme Q reductase. Biochem J (1995) 0.85
Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice. Aging Dis (2013) 0.82
Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. Biochim Biophys Acta (2012) 0.79
Modelling age-related metabolic disorders in the mouse. Mamm Genome (2014) 0.78
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev (2016) 0.78
Tissue-specific implications of mitochondrial alterations in aging. Front Biosci (Elite Ed) (2013) 0.76
Genomic sequence sampling: a strategy for high resolution sequence-based physical mapping of complex genomes. Nat Genet (1994) 14.90
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med (2000) 7.54
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell (1998) 3.25
Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J (2000) 2.58
Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma. Ann Surg (1996) 2.35
National estimates of outdoor air toxics concentrations. J Air Waste Manag Assoc (1999) 2.26
Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery (2000) 2.14
Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A (1995) 2.11
Playground injuries: a scientific appraisal of popular concerns. J R Soc Health (1991) 1.91
Mitochondrial role in life and death of the cell. J Biomed Sci (2000) 1.66
Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. Br J Cancer (2004) 1.64
Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett (1998) 1.57
Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA. Eur J Biochem (1999) 1.51
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome: report of a Chinese family with mitochondrial DNA point mutation in tRNA(Lys) gene. Muscle Nerve (1994) 1.45
Detection of serum hepatitis B, C, and D viral nucleic acids and its implications in hepatocellular carcinoma patients. J Gastroenterol (1998) 1.42
DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci (1996) 1.41
Mineralization and metabolic response in serially passaged adult rat bone cells. Calcif Tissue Int (1980) 1.41
Antenatal ultrasound diagnosis of fetal horseshoe kidney. J Ultrasound Med (1991) 1.39
Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun (1989) 1.38
Peripapillary fluorescein leakage in 11778 Leber's optic neuropathy. J Neuroophthalmol (1996) 1.37
Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cell Mol Life Sci (2008) 1.37
Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol (2001) 1.35
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility. Nat Genet (2001) 1.31
Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm. Biol Reprod (1995) 1.26
Effect of vitamin E-bonded membrane on the 8-hydroxy 2'-deoxyguanosine level in leukocyte DNA of hemodialysis patients. Kidney Int (2000) 1.25
Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations. Biochem J (1996) 1.24
Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma. Ann Surg (2000) 1.22
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations. J Clin Invest (1994) 1.20
Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations. Eur J Biochem (1999) 1.19
Prospective case-controlled trial of adjuvant chemotherapy after resection of hepatocellular carcinoma. World J Surg (2000) 1.19
Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta (1994) 1.18
Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol (1996) 1.18
An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy. Anal Biochem (1998) 1.17
Centripetal flow and directed reassembly of the major sperm protein (MSP) cytoskeleton in the amoeboid sperm of the nematode, Ascaris suum. Cell Motil Cytoskeleton (1991) 1.16
Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res (1999) 1.15
Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion. Eur J Biochem (1998) 1.14
Transmission of hepatitis C virus infection to tree shrews. Virology (1998) 1.14
Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo. Am J Physiol (1996) 1.14
Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity. J Biol Chem (1995) 1.14
Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth. Growth Regul (1991) 1.13
Detection of Epstein-Barr virus DNA in the peripheral-blood cells of patients with nasopharyngeal carcinoma: relationship to distant metastasis and survival. J Clin Oncol (2001) 1.11
Ageing and mammalian mitochondrial genetics. Trends Genet (1998) 1.09
Excavatolides F-M, new briarane diterpenes from the gorgonian Briareum excavatum. J Nat Prod (1999) 1.08
Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa. Mol Hum Reprod (1998) 1.08
Accumulation of mitochondrial DNA deletions in human oral tissues -- effects of betel quid chewing and oral cancer. Mutat Res (2001) 1.07
Electron nuclear double resonance of cytochrome oxidase: nitrogen and proton ENDOR from the 'copper' EPR signal. Biochim Biophys Acta (1978) 1.06
Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle. FEBS Lett (1994) 1.06
Amino acid sequence of subunit V of bovine heart cytochrome oxidase, the heme alpha-containing subunit. J Biol Chem (1979) 1.05
Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy. Nephrol Dial Transplant (1999) 1.04
The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system. Recent Prog Horm Res (1996) 1.04
Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. Neurobiol Aging (1994) 1.03
Surgical resection of primary hepatocellular carcinoma extending to adjacent organ(s). Eur J Surg Oncol (1996) 1.01
Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Childs' A patients. J Surg Oncol (1997) 1.01
Hysteroscopic resection of vaginal septum in an adolescent virgin with obstructed hemivagina. Hum Reprod (1998) 1.00
Hyperfine structure resolved by 2 to 4 GHz EPR of cytochrome c oxidase. J Biol Chem (1979) 1.00
Briaexcavatolides K-N, new briarane diterpenes from the gorgonian Briareum excavatum. J Nat Prod (2001) 0.99
Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience (1992) 0.99
Mitochondrial DNA mutation in a Chinese family with myoclonic epilepsy and ragged-red fiber disease. Biochem Biophys Res Commun (1991) 0.99
Biological response to ErbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression. Endocrinology (1998) 0.98
Calcium antagonists stimulate sperm motility in ejaculated human semen. Br J Clin Pharmacol (1985) 0.98
Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues. Am J Respir Cell Mol Biol (1998) 0.98
Bile duct injury and bile leakage in laparoscopic cholecystectomy. Br J Surg (1993) 0.97
Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion. Neurobiol Aging (2001) 0.96
Pseudo-Meigs syndrome and elevated levels of tumor markers associated with benign ovarian tumors--two case reports. Kaohsiung J Med Sci (2001) 0.95
Metastatic carcinoma of the cervix uteri from the gastrointestinal tract. Gynecol Oncol (1983) 0.95
Interaction in cytochrome c oxidase between cytochrome a3 ligated with nitric oxide and cytochrome a. J Biol Chem (1983) 0.95
Electron nuclear double resonance and electron paramagnetic resonance study on the structure of the NO-ligated heme alpha 3 in cytochrome c oxidase. J Biol Chem (1983) 0.95
Factors affecting the production of eremofortin C and PR toxin in Penicillium roqueforti. Appl Environ Microbiol (1991) 0.93
Esophageal manometric studies in patients with myasthenia gravis. J Thorac Cardiovasc Surg (1988) 0.93
Retroperitoneal cystic lymphangioma in adults. Int Surg (1994) 0.92
Molecular analysis and expression of the extracellular lipase of Aeromonas hydrophila MCC-2. Microbiology (1997) 0.92
Effect of emitted bioenergy on biochemical functions of cells. Am J Chin Med (1991) 0.92
In vitro and in vivo protective effect of honokiol on rat liver from peroxidative injury. Life Sci (1997) 0.92
Biochemical effects of PR toxin on rat liver mitochondrial respiration and oxidative phosphorylation. Arch Biochem Biophys (1984) 0.91
MELAS syndrome with mitochondrial tRNA(Leu(UUR)) gene mutation in a Chinese family. J Neurol Neurosurg Psychiatry (1994) 0.91
Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem Mol Biol Int (1994) 0.91
Mitochondrial DNA mutation in Leber's hereditary optic neuropathy. Invest Ophthalmol Vis Sci (1992) 0.91
The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA. Biochem J (1996) 0.90
Surgical treatment and outcome in patients with a hepatocellular carcinoma greater than 10 cm in diameter. Br J Surg (1998) 0.90
Calcium chelators stimulate sperm motility in ejaculated human semen. Lancet (1984) 0.90
Cloning and sequence analysis of a novel hemolysin gene (vllY) from Vibrio vulnificus. Appl Environ Microbiol (1997) 0.90
Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease. Exp Neurol (1993) 0.89
A sequence-tagged site map of human chromosome 11. Genomics (1993) 0.89
Mitochondrial respiration inhibitors and human sperm motility: implication in the development of spermicides. Br J Clin Pharmacol (1983) 0.89
Better post-resectional survival in female cirrhotic patients with hepatocellular carcinoma. Hepatogastroenterology (2000) 0.88
Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases. Int J Cancer (1997) 0.88
Effect of human OGG1 1245C-->G gene polymorphism on 8-hydroxy-2'-deoxyguanosine levels of leukocyte DNA among patients undergoing chronic hemodialysis. J Am Soc Nephrol (2001) 0.88
8-hydroxy-2'-deoxyguanosine of leukocyte DNA as a marker of oxidative stress in chronic hemodialysis patients. Am J Kidney Dis (2000) 0.88
Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging--smoking enhances oxidative stress on the aged tissues. Arch Biochem Biophys (1999) 0.88
Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria. Free Radic Biol Med (1994) 0.88
Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells. Endocrinology (1990) 0.88
Large-scale mitochondrial DNA deletions in skeletal muscle of patients with end-stage renal disease. Free Radic Biol Med (2000) 0.88
Evaluation of a simplified staging system for prognosis of hepatocellular carcinoma. J Formos Med Assoc (1999) 0.88
Isolation and Some Properties of the Enzyme That Transforms Eremofortin C to PR Toxin. Appl Environ Microbiol (1985) 0.88
Ophthalmologic manifestations in MELAS syndrome. Arch Neurol (1993) 0.87
Hepatic segmentectomy for curative resection of primary hepatocellular carcinoma. Arch Surg (1995) 0.87
Bcl-2 facilitates recovery from DNA damage after oxidative stress. Exp Neurol (1999) 0.87