Published in Proc Natl Acad Sci U S A on December 09, 1997
Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'. Nucleic Acids Res (2002) 6.07
Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest (2003) 3.84
The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet (2007) 2.25
Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study. Genome Biol (2011) 2.16
A critical reassessment of the role of mitochondria in tumorigenesis. PLoS Med (2005) 1.96
DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc Natl Acad Sci U S A (2005) 1.67
Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins. PLoS Genet (2011) 1.60
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Heteroplasmy as a common state of mitochondrial genetic information in plants and animals. Curr Genet (2006) 1.33
8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress. Free Radic Biol Med (2010) 1.20
Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Res (2009) 1.19
Single molecule PCR in mtDNA mutational analysis: Genuine mutations vs. damage bypass-derived artifacts. Methods (2008) 1.11
Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Arthritis Res Ther (2005) 1.07
Keeping mtDNA in shape between generations. PLoS Genet (2014) 0.98
Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism (2013) 0.95
Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism. Br J Cancer (2006) 0.93
A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Res (2000) 0.91
Mitochondrial DNA: impacting central and peripheral nervous systems. Neuron (2014) 0.90
Analysis of mutational spectra by denaturing capillary electrophoresis. Nat Protoc (2008) 0.84
Modifiers of hearing impairment in humans and mice. Curr Genomics (2010) 0.79
PON-mt-tRNA: a multifactorial probability-based method for classification of mitochondrial tRNA variations. Nucleic Acids Res (2016) 0.78
Mitochondrial DNA mutations in differentiated thyroid cancer with respect to the age factor. World J Surg (2007) 0.78
The approaches for manipulating mitochondrial proteome. Environ Mol Mutagen (2010) 0.76
Ligation of high-melting-temperature 'clamp' sequence extends the scanning range of rare point-mutational analysis by constant denaturant capillary electrophoresis (CDCE) to most of the human genome. Nucleic Acids Res (2003) 0.76
Calculating expected DNA remnants from ancient founding events in human population genetics. BMC Genet (2008) 0.75
Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age. Aging (Albany NY) (2016) 0.75
DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. Proc Natl Acad Sci U S A (1983) 10.79
Human mitochondrial DNA variation and evolution: analysis of nucleotide sequences from seven individuals. Genetics (1983) 9.22
INDUCTION OF SPECIFIC MUTATIONS WITH 5-BROMOURACIL. Proc Natl Acad Sci U S A (1958) 6.25
Fidelity of DNA polymerases in DNA amplification. Proc Natl Acad Sci U S A (1989) 5.56
Intraspecific nucleotide sequence differences in the major noncoding region of human mitochondrial DNA. Am J Hum Genet (1990) 4.89
Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors. Proc Natl Acad Sci U S A (1987) 4.35
Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res (1990) 3.13
Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A (1994) 2.96
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice. Nat Genet (1997) 2.69
The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. J Biol Chem (1985) 2.66
Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic Biol Med (1990) 2.13
Analysis of spontaneous base substitutions generated in mismatch-repair-deficient strains of Escherichia coli. J Bacteriol (1986) 1.91
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem Biophys Res Commun (1978) 1.91
Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell (1990) 1.90
Site and strand specificity of UVB mutagenesis in the SUP4-o gene of yeast. Proc Natl Acad Sci U S A (1990) 1.61
In vivo human somatic mutation: frequency and spectrum with age. Mutat Res (1992) 1.42
Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim Biophys Acta (1992) 1.40
Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis. Nucleic Acids Res (1994) 1.39
Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence. Genome Res (1997) 1.34
Mutational spectra in human B-cells. Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene. J Mol Biol (1992) 1.20
Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem Int (1990) 1.19
Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing--a cytochemical-immunohistochemical study. Mutat Res (1992) 1.16
The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett (1993) 1.13
Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection. Mutat Res (1991) 1.12
Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem Biophys Res Commun (1991) 1.09
Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am J Hum Genet (1996) 1.02
Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun (1993) 1.01
Mutational spectrometry without phenotypic selection: human mitochondrial DNA. Nucleic Acids Res (1997) 1.00
Mapping large spontaneous deletion endpoints in the human HPRT gene. Mutat Res (1988) 0.97
Predominant mutations induced by the Thermococcus litoralis, vent DNA polymerase during DNA amplification in vitro. PCR Methods Appl (1993) 0.95
Mutational spectrometry in animal toxicity testing. Annu Rev Pharmacol Toxicol (1990) 0.89
An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets. Mutat Res (1994) 0.88
Mutational spectrum induced in Saccharomyces cerevisiae by the carcinogen N-2-acetylaminofluorene. Mol Gen Genet (1994) 0.85
Efficiency of separation of DNA mutations by constant denaturant capillary electrophoresis is controlled by the kinetics of DNA melting equilibrium. Electrophoresis (1996) 0.82
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
Fidelity of DNA polymerases in DNA amplification. Proc Natl Acad Sci U S A (1989) 5.56
Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich. Am J Hum Genet (1988) 3.50
Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23. Am J Hum Genet (2000) 3.48
Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene. PCR Methods Appl (1992) 3.42
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med (1999) 3.17
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci U S A (1993) 3.07
High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet (2001) 2.95
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med (1999) 2.74
Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker. Proc Natl Acad Sci U S A (1978) 2.65
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell (1994) 2.59
DNA amplification in vitro using T4 DNA polymerase. DNA (1988) 2.45
Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res (2001) 2.27
Mutational spectrum of chromium(VI) in human cells. Mutat Res (1994) 2.09
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem Biophys Res Commun (1978) 1.91
A mutation in PDS causes non-syndromic recessive deafness. Nat Genet (1998) 1.79
Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium. Proc Natl Acad Sci U S A (1978) 1.74
Deletion mutagenesis during polymerase chain reaction: dependence on DNA polymerase. Gene (1991) 1.71
Optimization of the polymerase chain reaction with regard to fidelity: modified T7, Taq, and vent DNA polymerases. PCR Methods Appl (1991) 1.67
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res (1999) 1.64
Rapamycin induces transforming growth factor-beta production by lymphocytes. Transplantation (2000) 1.56
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. J Biol Chem (1986) 1.53
Natural CD8+CD122+ T cells are more potent in suppression of allograft rejection than CD4+CD25+ regulatory T cells. Am J Transplant (2013) 1.52
Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat Res (1982) 1.44
Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. Anal Biochem (1981) 1.40
Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis. Nucleic Acids Res (1994) 1.39
Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191. Mutat Res (1990) 1.35
Specificity, efficiency, and fidelity of PCR. PCR Methods Appl (1993) 1.35
Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence. Genome Res (1997) 1.34
Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol (1998) 1.32
Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes. Environ Health Perspect (1995) 1.32
Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer Res (1979) 1.32
Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism. Mutat Res (1984) 1.28
Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. Mutat Res (2000) 1.26
N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations. Proc Natl Acad Sci U S A (1994) 1.24
Mutational spectra in human B-cells. Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene. J Mol Biol (1992) 1.20
Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense. Planta Med (2000) 1.20
Cell density dependence of focus formation in the C3H/10T1/2 transformation assay. Cancer Res (1977) 1.20
Mitochondrial mutagenesis in human cells and tissues. Mutat Res (1999) 1.19
Bacterial and human cell mutagenicity study of some C18H10 cyclopenta-fused polycyclic aromatic hydrocarbons associated with fossil fuels combustion. Environ Health Perspect (1993) 1.18
Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment. Transplantation (1998) 1.14
Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States. Mutat Res (2000) 1.13
Potential use of gradient denaturing gel electrophoresis in obtaining mutational spectra from human cells. Carcinog Compr Surv (1985) 1.13
Chemical and toxicological characterization of residential oil burner emissions: II. Mutagenic, tumorigenic, and potential teratogenic activity. Environ Health Perspect (1987) 1.13
Virus production with a newly developed microcarrier system. Appl Environ Microbiol (1977) 1.12
Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J Immunol (2001) 1.08
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol (1999) 1.08
Poisson statistical analysis of repetitive subcloning by the limiting dilution technique as a way of assessing hybridoma monoclonality. Methods Enzymol (1986) 1.08
Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutat Res (1998) 1.08
Prevalence of primary Sjögren's syndrome in China. J Rheumatol (1995) 1.07
Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study. Cancer Res (1995) 1.07
A statistical model to estimate variance in long term-low dose mutation assays: testing of the model in a human lymphoblastoid mutation assay. Mutat Res (1989) 1.07
Optimization of environment for high density Vero cell culture: effect of dissolved oxygen and nutrient supply on cell growth and changes in metabolites. J Cell Sci (1986) 1.06
Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. J Interferon Cytokine Res (2000) 1.05
Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes. Proc Natl Acad Sci U S A (1992) 1.05
Microsomal activation of fluoranthene to mutagenic metabolites. Toxicol Appl Pharmacol (1986) 1.04
An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection. J Immunol (2001) 1.03
Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers. Am J Respir Cell Mol Biol (1997) 1.03
Human cell mutagenicity of polycyclic aromatic hydrocarbon components of diesel emissions. Dev Toxicol Environ Sci (1982) 1.03
A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene. Genomics (1998) 1.02
Enzymatic amplification and characterization of large DNA fragments from genomic DNA. Gene (1988) 1.02
Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res (2000) 1.01
Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for rise of mortal disease. Gene (1998) 1.01
Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci. Mutat Res (1985) 1.01
IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. J Immunol (1999) 1.01
Mutation of human lymphoblasts by methylnitrosourea. Chem Biol Interact (1976) 1.00
Statistical analysis of repetitive subcloning by the limiting dilution technique with a view toward ensuring hybridoma monoclonality. Hybridoma (1983) 1.00
Mutational spectrometry without phenotypic selection: human mitochondrial DNA. Nucleic Acids Res (1997) 1.00
Combined small bowel and liver transplantation in the rat: possible role of the liver in preventing intestinal allograft rejection. Transplantation (1991) 1.00
Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A (2000) 0.99
Label-free detection with micro optical fluidic systems (MOFS): a review. Anal Bioanal Chem (2008) 0.99
Evolutionary trail of the mitochondrial genome as based on human 16S rDNA pseudogenes. Gene (1994) 0.99
Oligomeric proanthocyanidins: naturally occurring O-heterocycles. Nat Prod Rep (2000) 0.99
Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts. Mutat Res (1978) 0.98
Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. Am J Respir Cell Mol Biol (1996) 0.98
Maternally inherited nonsyndromic hearing loss. Am J Med Genet (1999) 0.97
Mutation of human cells by kerosene soot. J Natl Cancer Inst (1979) 0.97
Mapping large spontaneous deletion endpoints in the human HPRT gene. Mutat Res (1988) 0.97
Combination of competitive quantitative PCR and constant-denaturant capillary electrophoresis for high-resolution detection and enumeration of microbial cells. Appl Environ Microbiol (2001) 0.97
Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo. Am J Transplant (2007) 0.95
General approach to the biological analysis of complex mixtures. Environ Health Perspect (1983) 0.95
Predominant mutations induced by the Thermococcus litoralis, vent DNA polymerase during DNA amplification in vitro. PCR Methods Appl (1993) 0.95
Profound, prelingual nonsyndromic deafness maps to chromosome 10q21 and is caused by a novel missense mutation in the Usher syndrome type IF gene PCDH15. Eur J Hum Genet (2008) 0.95
Theoretical study and pathways for nanoparticle capture during solidification of metal melt. J Phys Condens Matter (2012) 0.95
Killing and mutation of human lymphoblast cells by aflatoxin B1: evidence for an inducible repair response. Cancer Res (1987) 0.94
Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Carcinogenesis (1998) 0.94
Morphological transformation of C3H/10T1/2 cells subcultured at low cell densities. Life Sci (1978) 0.94
Chemically induced mutations in mitochondrial DNA of human cells: mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res (1998) 0.92
Bell-shaped nuclei dividing by symmetrical and asymmetrical nuclear fission have qualities of stem cells in human colonic embryogenesis and carcinogenesis. Cancer Genet Cytogenet (2006) 0.92
A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Res (2000) 0.91
Microcarrier cell culture: new methods for research-scale application. Somatic Cell Genet (1977) 0.91
Mutational spectrometry: means and ends. Prog Nucleic Acid Res Mol Biol (1994) 0.90
9-Aminoacridine-A frameshift mutagen for Salmonella typhimurium TA 1537 inactive at the hgprt locus in human lymphoblasts. Mutat Res (1977) 0.90
Human interferon production with diploid fibroblast cells grown on microcarriers. Biotechnol Bioeng (1979) 0.90