Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly.

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Published in Biochim Biophys Acta on May 31, 2012

Authors

Gregory J Tranah1, Ernest T Lam, Shana M Katzman, Michael A Nalls, Yiqiang Zhao, Daniel S Evans, Jennifer S Yokoyama, Ludmila Pawlikowska, Pui-Yan Kwok, Sean Mooney, Stephen Kritchevsky, Bret H Goodpaster, Anne B Newman, Tamara B Harris, Todd M Manini, Steven R Cummings, Health, Aging and Body Composition Study

Author Affiliations

1: California Pacific Medical Center Research Institute, San Francisco, San Francisco, CA 94107, USA. gtranah@sfcc-cpmc.edu

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A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet (2009) 19.64

Genetic mapping in human disease. Science (2008) 15.12

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Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11

Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet (2006) 9.80

Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A (1980) 9.48

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc Natl Acad Sci U S A (2006) 8.20

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89

Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation. World Health Organ Tech Rep Ser (1985) 6.87

Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev (2009) 6.85

Effects of purifying and adaptive selection on regional variation in human mtDNA. Science (2004) 5.87

Medical sequencing at the extremes of human body mass. Am J Hum Genet (2007) 5.61

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem (2002) 4.48

Daily activity energy expenditure and mortality among older adults. JAMA (2006) 4.36

Automated inference of molecular mechanisms of disease from amino acid substitutions. Bioinformatics (2009) 4.31

Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med (2007) 3.92

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab (2011) 3.69

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet (1992) 3.53

Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell (2008) 3.38

Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet (1989) 3.27

Changes in physical activity, mortality, and incidence of coronary heart disease in older men. Lancet (1998) 3.08

Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07

The sites and topology of mitochondrial superoxide production. Exp Gerontol (2010) 2.91

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A (1992) 2.83

The structure of human mitochondrial DNA variation. J Mol Evol (1991) 2.78

Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J (1999) 2.61

The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res (2004) 2.54

Relationship of changes in physical activity and mortality among older women. JAMA (2003) 2.42

Cytochrome c oxidase deficiency. Am J Med Genet (2001) 2.41

Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine. Annu Rev Biochem (2007) 2.39

Human energy expenditure in affluent societies: an analysis of 574 doubly-labelled water measurements. Eur J Clin Nutr (1996) 2.29

Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase. EMBO J (2007) 2.28

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Smoking, physical activity, and active life expectancy. Am J Epidemiol (1999) 2.16

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet (1992) 2.16

Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet (2002) 2.00

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res (1992) 1.97

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol (2009) 1.94

Structure of the membrane domain of respiratory complex I. Nature (2011) 1.93

Cytochrome c oxidase mutations in Leber hereditary optic neuropathy. Biochem Biophys Res Commun (1993) 1.92

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res (1995) 1.84

Physical activity, falls, and fractures among older adults: a review of the epidemiologic evidence. J Am Geriatr Soc (2000) 1.81

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol (1995) 1.79

Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78

The response to exercise with constant energy intake in identical twins. Obes Res (1994) 1.77

Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern. J Mol Biol (2005) 1.74

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci (1992) 1.74

Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations. Proc Natl Acad Sci U S A (1997) 1.65

cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc Natl Acad Sci U S A (1987) 1.64

Mitochondria and aging: the universality of bioenergetic disease. Aging (Milano) (1992) 1.63

A mitochondrial paradigm for degenerative diseases and ageing. Novartis Found Symp (2001) 1.63

Towards the molecular mechanism of respiratory complex I. Biochem J (2009) 1.59

Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genet (2009) 1.58

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Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta (1995) 1.50

A proposed refinement of the mitochondrial free radical theory of aging. Bioessays (1997) 1.48

Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta (1994) 1.48

Energy requirements in the eighth decade of life. Am J Clin Nutr (2004) 1.46

Cytochrome b mutations in Leber hereditary optic neuropathy. Biochem Biophys Res Commun (1991) 1.45

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J Biol Chem (1986) 1.45

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim Biophys Acta (1992) 1.40

Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N Engl J Med (1983) 1.40

Genetic analysis of physical activity in twins. Am J Clin Nutr (2005) 1.40

Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc Natl Acad Sci U S A (1996) 1.38

Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun (1989) 1.38

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Resistance training, sarcopenia, and the mitochondrial theory of aging. Appl Physiol Nutr Metab (2008) 1.35

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mech Ageing Dev (1988) 1.33

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet (2002) 1.32

Mitochondrial DNA mutations in diseases of energy metabolism. J Bioenerg Biomembr (1994) 1.28

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Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res (1992) 1.27

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Leber's hereditary optic neuropathy: the etiological role of a mutation in the mitochondrial cytochrome b gene. Genetics (1993) 1.23

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Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. Am Heart J (1991) 1.20

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Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem Int (1990) 1.19

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