Published in Science on June 02, 1978
Suppressive effects of 24,25-dihydroxycholecalciferol on bone resorption induced by acute bilateral nephrectomy in rats. J Clin Invest (1981) 0.78
Vitamin D metabolism and its possible role in the developing chick embryo. Biochem J (1981) 0.75
Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab (2004) 6.41
Current understanding of the molecular actions of vitamin D. Physiol Rev (1998) 4.05
Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces, and urine. J Clin Invest (1967) 3.69
Biologically active metabolite of vitamin D3 from bone, liver, and blood serum. J Lipid Res (1966) 3.39
25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry (1968) 3.01
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.95
Biological activity of 25-hydroxyergocalciferol in rats. J Nutr (1970) 2.85
Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys (2000) 2.65
Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science (1979) 2.57
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science (1972) 2.50
Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry (1971) 2.50
Metabolism and mechanism of action of vitamin D. Annu Rev Biochem (1976) 2.49
"Activation" of vitamin D by the liver. J Clin Invest (1969) 2.42
Mechanism of action and metabolic fate of vitamin D. Vitam Horm (1967) 2.42
Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proc Natl Acad Sci U S A (1971) 2.27
A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. Arch Biochem Biophys (1976) 2.23
The role of the liver in the metabolism of vitamin D. J Clin Invest (1969) 2.22
Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest (1979) 2.21
A rapid assay for 25-OH-vitamin D3 without preparative chromatography. J Clin Endocrinol Metab (1974) 2.20
A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite. J Lipid Res (1971) 2.12
Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna. Science (1972) 2.12
1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr (1998) 2.06
Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest (1979) 2.02
Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc Natl Acad Sci U S A (1990) 1.99
Vitamin D: recent advances. Annu Rev Biochem (1983) 1.99
The synthesis of [1,2-3H]vitamin D3 and the tissue localization of a 0.25-mu-g (10 IU) dose per rat. Biochemistry (1966) 1.99
Vitamin D metabolism: the role of kidney tissue. Science (1971) 1.91
Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch Biochem Biophys (1993) 1.89
Regulation of vitamin D metabolism and function. Physiol Rev (1973) 1.88
Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta (1994) 1.85
Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A (1971) 1.78
Biological activity of 1,25-dihydroxycholecalciferol. Biochemistry (1971) 1.77
DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1990) 1.77
Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. Biochim Biophys Acta (1995) 1.69
21,25-dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on bone. Biochemistry (1970) 1.65
Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: interaction with distinct receptor domains. Biochemistry (1986) 1.64
Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney. Biochemistry (1972) 1.62
25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. J Biol Chem (1972) 1.62
Subcellular location of vitamin D and its metabolites in intestinal mucosa after a 10-IU dose. Biochemistry (1967) 1.61
1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci U S A (1983) 1.60
Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. N Engl J Med (1978) 1.59
25-hydroxycholecalciferol. The probable metabolically active form of vitamin D3: its identification and subcellular site of action. Arch Intern Med (1969) 1.58
Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J (1979) 1.58
The kidney as an endocrine organ for the production of 1,25-dihydroxyvitamin D 3 , a calcium-mobilizing hormone. N Engl J Med (1973) 1.54
Pathogenesis of hereditary vitamin-D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. N Engl J Med (1973) 1.50
In vitro production of 25-hydroxycholecalciferol. Biochem Biophys Res Commun (1969) 1.48
Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase. J Biol Chem (1974) 1.45
Rat intestinal 25-hydroxyvitamin D3- and 1alpha,25-dihydroxyvitamin D3-24-hydroxylase. J Biol Chem (1978) 1.44
Current concepts. Vitamin D. N Engl J Med (1969) 1.43
Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice. J Nutr (1999) 1.41
1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol (1998) 1.41
Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1992) 1.41
25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. Biochemistry (1970) 1.40
Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med (1978) 1.40
The vitamin D system in the regulation of calcium and phosphorus metabolism. Nutr Rev (1979) 1.39
A specific high-affinity binding macromolecule for 1,25-dihydroxyvitamin D3 in fetal bone. Science (1977) 1.38
Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci U S A (1998) 1.38
Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues. Cancer Res (1984) 1.37
Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab (1980) 1.37
Metabolism of tritiated vitamin D3 in familial vitamin D-resistant rickets with hypophosphatemia. J Pediatr (1967) 1.37
Vitamin D: the vitamin and the hormone. Fed Proc (1974) 1.36
Vitamin D stimulated, calcium-dependent adenosine triphosphatase from brush borders of rat small intestine. Biochem Biophys Res Commun (1969) 1.35
Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion. J Biol Chem (1976) 1.34
Reduction in 1,25-dihydroxyvitamin D in children with increased lead absorption. N Engl J Med (1980) 1.34
Stimulation of 24,25-dihydroxyvitamin D3 production by 1,25-dihydroxyvitamin D3. Science (1974) 1.33
Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D: evidence for impaired conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. N Engl J Med (1975) 1.33
Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer. J Clin Endocrinol Metab (1981) 1.32
Influence of sodium on calcium transport by the rat small intestine. Am J Physiol (1969) 1.31
Direct chemical synthesis of 1 alpha,25-dihydroxy[26,27-3H]vitamin D3 with high specific activity: its use in receptor studies. Biochemistry (1980) 1.30
Subcellular location of rat liver calciferol-25-hydroxylase. Arch Biochem Biophys (1974) 1.29
Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3. Proc Natl Acad Sci U S A (1968) 1.29
Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting. Proc Natl Acad Sci U S A (1985) 1.29
The role of vitamin D and its relationship to parathyroid hormone and calcitonin. Recent Prog Horm Res (1971) 1.28
Vitamin D is not directly necessary for bone growth and mineralization. Am J Physiol (1984) 1.28
25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties. Biochemistry (1974) 1.28
Rickets with alopecia: an inborn error of vitamin D metabolism. J Pediatr (1979) 1.27
Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children. Am J Clin Nutr (1982) 1.26
1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay. Science (1976) 1.26
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats. Science (1972) 1.26
Role of vitamin D metabolites in phosphate transport of rat intestine. J Nutr (1974) 1.25
Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab (1992) 1.24
1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism. Proc Natl Acad Sci U S A (1983) 1.24
Metaboism of 25-hydroxycholecalciferol in target and nontarget tissues. Biochemistry (1970) 1.24
Effect of I,25-dihydroxycholecalciferol in renal osteodystrophy. Can Med Assoc J (1975) 1.24
Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J Nutr (1980) 1.22
Control of renal vitamin D hydroxylases in birds by sex hormones. Proc Natl Acad Sci U S A (1976) 1.21
Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Arch Biochem Biophys (2000) 1.21
The synthesis of 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry (1969) 1.21
New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. J Med Chem (1998) 1.21
Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA. Proc Natl Acad Sci U S A (1997) 1.20
Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter. J Biol Chem (1995) 1.20
ApaI, BsmI, EcoRV and TaqI polymorphisms at the human vitamin D receptor gene locus in Caucasians, blacks and Asians. Hum Mol Genet (1993) 1.20
The physiologic significance of plasma transport of vitamin D and metabolites. Am J Med (1974) 1.20
Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k gene. Proc Natl Acad Sci U S A (1992) 1.19
Rickets of prematurity. Supranormal levels of serum 1,25-dihydroxyvitamin D. Am J Dis Child (1981) 1.19
Binding proteins for vitamin D metabolites: serum carriers and intracellular receptors. Arch Biochem Biophys (1981) 1.18
Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat. J Clin Invest (1976) 1.18
The regulation of rat liver calciferol-25-hydroxylase. J Biol Chem (1973) 1.18
25-Hydroxyvitamin D3 26,23-lactone: a new in vivo metabolite of vitamin D. Biochemistry (1979) 1.18
Inhibition of the metabolism of 25-hydroxycholecalciferol by actinomycin D and cycloheximide. Proc Natl Acad Sci U S A (1971) 1.18