A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole.

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Published in J Cell Biol on August 11, 1997

Authors

T Darsow1, S E Rieder, S D Emr

Author Affiliations

1: Division of Cellular and Molecular Medicine and Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093-0668, USA.

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A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Mol Biol Cell (1997) 2.24

Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc Natl Acad Sci U S A (1990) 2.18

Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J (1999) 2.18

COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol (1997) 2.16

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol (1999) 2.15

A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell (1997) 2.14

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways. Curr Opin Cell Biol (1998) 2.13

Location, location, location: membrane targeting directed by PX domains. Science (2001) 2.09

Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell (2001) 1.99

Importance of secondary structure in the signal sequence for protein secretion. Proc Natl Acad Sci U S A (1983) 1.98

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J (1991) 1.93

The AP-3 complex: a coat of many colours. Trends Cell Biol (1998) 1.92

Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.91

D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol (1984) 1.89

In vitro reconstitution of intercompartmental protein transport to the yeast vacuole. J Cell Biol (1990) 1.85

Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci (1999) 1.84

Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem (1999) 1.80

Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J Cell Biol (1994) 1.79

Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell (1999) 1.76

The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic (2001) 1.73

AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc Natl Acad Sci U S A (1994) 1.72

Yeast Gga coat proteins function with clathrin in Golgi to endosome transport. Mol Biol Cell (2001) 1.72

Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol (1999) 1.69

Molecular components of the signal sequence that function in the initiation of protein export. J Cell Biol (1982) 1.65

A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol (1995) 1.64

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. EMBO J (1993) 1.59

Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J Cell Biol (1998) 1.58

The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem (1993) 1.58